iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094366

UUCD1 version

UUC-PeM-00517

Ensembl Protein ID

ENSPMAP00000006792.1

UniProt Accession

S4RNK6; S4RNK6_PETMA

Protein Name

Ubiquitin thioesterase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000006140.1	ENSPMAT00000006822.1	ENSPMAP00000006792.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.50e-43	145.5	80	270

Active Site

Position(s)	Description	Evidence
86	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
89	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
264		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs...........................................................llgvfdddslsd 32
           i+ t+ DGnC++rA++++                                                           + g+f+++s+sd
   Q: 80   IRMTRRDGNCFYRAFGFAhlealmdnpkdlqnrfktvaakskdelvslgfpeftiedfhstfldiiemvekqasledVRGSFNEQSTSD 168
           789************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts ylqkes ff++f+e+++++kefc ++vep+ak +++ihi+aLaq+L ++i v+++d++e   gg ++++ fpe   +
   Q: 169  YVVVYLRLLTSGYLQKESIFFEHFVEGGRTVKEFCSQEVEPMAKeSDHIHIIALAQALGVSIRVEYMDRGE---GGSVNHHDFPEGT-E 253
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           + ++LlYr+gHYd+L++
   Q: 254  PFVYLLYRPGHYDILYK 270
           ***************97 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

MAEQQEQQPE QVKLEVEVDD TQAYDEAIIA QQEKIQQEIA MATPLISDKH DISVLMREYN 60
DDDEIYQKKI KDLCNKYSHI RMTRRDGNCF YRAFGFAHLE ALMDNPKDLQ NRFKTVAAKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAAGATGGC GGAGCAGCAA GAGCAGCAGC CCGAGCAGGT TAAGCTCGAA GTGGAAGGTT 60
CGTGTTGAGG AGGAGAGGGC ATCGTCAAAC CAACAACAAC AAAAAACCAC ACACGCAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0378--Hydrolase
KW-0645--Protease
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	75.81	9.00e-112	394.00
IUUC-Apl-003233	Anas platyrhynchos	49.23	4.00e-15	70.90
IUUC-Aca-004648	Anolis carolinensis	72.11	1.00e-105	374.00
IUUC-Aly-005710	Arabidopsis lyrata	43.41	5.00e-54	202.00
IUUC-Ath-007112	Arabidopsis thaliana	42.37	4.00e-54	203.00
IUUC-Afl-008439	Aspergillus flavus	34.18	9.00e-09	52.40
IUUC-Ame-010662	Astyanax mexicanus	71.88	6.00e-109	385.00
IUUC-Bta-013533	Bos taurus	75.00	1.00e-110	390.00
IUUC-Bol-016100	Brassica oleracea	42.21	6.00e-53	199.00
IUUC-Bra-017705	Brassica rapa	39.93	1.00e-48	185.00
IUUC-Cel-018295	Caenorhabditis elegans	34.69	2.00e-42	164.00
IUUC-Cja-019190	Callithrix jacchus	75.81	1.00e-111	394.00
IUUC-Cfa-020430	Canis familiaris	75.81	1.00e-111	393.00
IUUC-Cpo-022355	Cavia porcellus	75.81	6.00e-112	395.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.01	3.00e-44	170.00
IUUC-Csa-023286	Chlorocebus sabaeus	73.15	2.00e-109	386.00
IUUC-Cho-024411	Choloepus hoffmanni	41.04	3.00e-29	119.00
IUUC-Cin-025507	Ciona intestinalis	42.62	1.00e-45	174.00
IUUC-Csv-026273	Ciona savignyi	50.60	2.00e-73	266.00
IUUC-Dre-027843	Danio rerio	71.77	4.00e-107	379.00
IUUC-Dno-029165	Dasypus novemcinctus	78.11	2.00e-92	330.00
IUUC-Dor-030943	Dipodomys ordii	75.81	6.00e-112	395.00
IUUC-Dme-031922	Drosophila melanogaster	55.38	1.00e-76	277.00
IUUC-Ete-032296	Echinops telfairi	76.97	5.00e-74	269.00
IUUC-Eca-033695	Equus caballus	75.00	1.00e-110	390.00
IUUC-Eeu-034775	Erinaceus europaeus	42.67	8.00e-55	205.00
IUUC-Fca-036441	Felis catus	75.81	2.00e-111	393.00
IUUC-Gmo-038908	Gadus morhua	71.09	3.00e-107	379.00
IUUC-Ggr-040020	Gaeumannomyces graminis	30.53	1.00e-28	120.00
IUUC-Gga-040460	Gallus gallus	68.15	1.00e-100	357.00
IUUC-Gac-042417	Gasterosteus aculeatus	73.79	3.00e-109	386.00
IUUC-Gma-043712	Glycine max	43.49	1.00e-54	205.00
IUUC-Ggo-044552	Gorilla gorilla	70.90	5.00e-76	275.00
IUUC-Hsa-046766	Homo sapiens	75.81	8.00e-112	394.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	75.81	6.00e-112	395.00
IUUC-Lch-050602	Latimeria chalumnae	68.55	1.00e-97	347.00
IUUC-Loc-052003	Lepisosteus oculatus	46.02	1.00e-53	201.00
IUUC-Laf-053705	Loxodonta africana	75.81	6.00e-112	395.00
IUUC-Mcc-055745	Macaca mulatta	70.68	2.00e-108	383.00
IUUC-Meu-056569	Macropus eugenii	67.34	4.00e-95	339.00
IUUC-Mtr-057712	Medicago truncatula	41.64	5.00e-49	186.00
IUUC-Mvi-060358	Microbotryum violaceum	30.77	3.00e-14	70.90
IUUC-Mmr-061123	Microcebus murinus	74.16	4.00e-90	322.00
IUUC-Mdo-062613	Monodelphis domestica	69.76	1.00e-87	314.00
IUUC-Mmu-063658	Mus musculus	75.81	6.00e-112	395.00
IUUC-Mac-065274	Musa acuminata	34.80	2.00e-36	144.00
IUUC-Mpu-066172	Mustela putorius furo	75.81	8.00e-112	394.00
IUUC-Mlu-066966	Myotis lucifugus	75.81	1.00e-111	394.00
IUUC-Nle-069519	Nomascus leucogenys	71.43	6.00e-77	278.00
IUUC-Opr-070761	Ochotona princeps	33.12	5.00e-25	105.00
IUUC-Ont-071901	Oreochromis niloticus	74.19	2.00e-109	386.00
IUUC-Oan-072922	Ornithorhynchus anatinus	45.78	9.00e-58	214.00
IUUC-Ocu-074643	Oryctolagus cuniculus	44.00	5.00e-56	209.00
IUUC-Oni-082026	Oryza nivara	28.64	2.00e-14	72.40
IUUC-Oru-084761	Oryza rufipogon	28.64	2.00e-14	72.40
IUUC-Osa-085462	Oryza sativa	28.12	5.40e-01	27.70
IUUC-Ola-087331	Oryzias latipes	74.30	5.00e-78	281.00
IUUC-Oga-088064	Otolemur garnettii	75.81	8.00e-112	394.00
IUUC-Oar-089251	Ovis aries	75.00	3.00e-110	389.00
IUUC-Ptr-091430	Pan troglodytes	75.81	1.00e-111	394.00
IUUC-Pan-091969	Papio anubis	43.11	2.00e-55	207.00
IUUC-Psi-093823	Pelodiscus sinensis	70.52	6.00e-103	365.00
IUUC-Pfo-096734	Poecilia formosa	71.77	2.00e-99	353.00
IUUC-Pab-097919	Pongo abelii	74.16	2.00e-89	320.00
IUUC-Pop-099401	Populus trichocarpa	41.84	1.00e-52	198.00
IUUC-Pca-100252	Procavia capensis	57.81	1.00e-17	81.30
IUUC-Ppe-101977	Prunus persica	43.12	2.00e-54	204.00
IUUC-Pva-102499	Pteropus vampyrus	75.81	8.00e-112	394.00
IUUC-Pgr-103552	Puccinia graminis	50.00	2.30e-01	26.90
IUUC-Rno-105233	Rattus norvegicus	75.81	6.00e-112	395.00
IUUC-Sha-107081	Sarcophilus harrisii	74.60	2.00e-110	390.00
IUUC-Sly-111640	Solanum lycopersicum	43.01	2.00e-51	194.00
IUUC-Sar-113295	Sorex araneus	44.00	8.00e-56	208.00
IUUC-Ssc-116202	Sus scrofa	75.81	8.00e-112	394.00
IUUC-Tru-117664	Takifugu rubripes	73.02	3.00e-108	382.00
IUUC-Tni-120440	Tetraodon nigroviridis	40.35	3.00e-34	137.00
IUUC-Tca-121467	Theobroma cacao	42.49	4.00e-54	203.00
IUUC-Tbe-128116	Tupaia belangeri	80.50	3.00e-75	273.00
IUUC-Ttr-128622	Tursiops truncatus	75.71	4.00e-111	392.00
IUUC-Uma-129443	Ustilago maydis	31.05	2.00e-20	91.70
IUUC-Vvi-131389	Vitis vinifera	42.71	2.00e-55	207.00
IUUC-Xtr-131951	Xenopus tropicalis	45.22	5.00e-57	212.00
IUUC-Xma-134191	Xiphophorus maculatus	72.98	4.00e-101	359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence