iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011183

Ensembl Protein ID

ENSAMXP00000003002.1

UniProt Accession

W5K5Z1; W5K5Z1_ASTMX

Genbank Protein ID

ENSAMXP00000003002

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

APWO01030408

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000002934.1	ENSAMXT00000003002.1	ENSAMXP00000003002.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.50e-118	396.1	12	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l++a+ +l++a ++G+E+lKnL+l G+g +t+vD+++v+ ++++++F+++ e++gk++A++a e+l+eln+dv+
   Q: 12   YDRQLRLWGDHGQEALENAHTCLLNASATGTEILKNLILPGIGAFTIVDGHKVTGEDVGNNFFLSCESIGKNRAQAATEFLQELNSDVS 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ees+++l ++++ Ff +f++V+  + ++++  ++  ++++a vp++ ++t+Gl+G++r ++k++t+ +s++d   +++++++Pf 
   Q: 101  GNFVEESPDKLLDNDPeFFHRFSLVIGVQLPESTCQRLGAVLWSAGVPFLVCRTYGLVGYMRLVVKEHTVVESHPDnalEDLRLDQPFT 189
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+++++         +++++++w+ +++k+le+++ e++++ +++++eke +++++++++++      e+eenf+eai+++++a+++t
   Q: 190  ELRNHISsyhldsmdkKDHSHTPWIIVIAKYLEKWYNEHNCQLPKNYKEKEVFRQLIRDGIRKnengapEEEENFDEAIKNVNTALNPT 278
           *****99999999999*****************************************************9******************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i+s + +++++ +c+++t+++s+fw+                                                              
   Q: 279  KISStVDDIFNCVQCENITSQTSAFWMmargvrdfvqnegngslpvrgtipdmiadsdkfinlqnvyrekalqdaavvskhiqshlqav 367
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavd 334
                         fc+ a+ l+v            ++  kd++++ +++p     lyl+lr+++rf ++++r+pg+ ++++++d + +
   Q: 368  gkpsesiseqdikLFCKSAAFLRVVrcrslaeeystDTFQKDTITSCMDSPdsemvLYLMLRSVDRFYQQHSRYPGVYNYQVEED-ISK 455
           *************9999999999555666666666677888887777777778888*****************************.888 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           l+  + +l  +++g++ +++dd+++e++++++++ +t+++++gG+aaqE+iK+++++f+p++n+f+++a+
   Q: 456  LKLCVNSLL-QEHGLSVNVKDDYVHEFCRYGAAEPHTVASFLGGAAAQEAIKLITHQFVPFNNTFIYNAM 524
           888888887.99***999*************************************************997 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MSEQKTNKEQ RYDRQLRLWG DHGQEALENA HTCLLNASAT GTEILKNLIL PGIGAFTIVD 60
GHKVTGEDVG NNFFLSCESI GKNRAQAATE FLQELNSDVS GNFVEESPDK LLDNDPEFFH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCAGATGA GTGAAGGTAG CGAGTGGATA AGGGCGCAGG GAGCAGGGAG CGGATTGGGA 60
CGGGGCCGGG TCTGTGGCGA ATCTGCGGAC GGGGTAGTTA TATGGCGGAG GGAGCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.30	3.00e-120	425.00
IUUC-Aml-002333	Ailuropoda melanoleuca	72.13	0.00e+00	829.00
IUUC-Atr-002644	Amborella trichopoda	38.79	2.00e-108	386.00
IUUC-Apl-003446	Anas platyrhynchos	72.45	0.00e+00	795.00
IUUC-Aca-004450	Anolis carolinensis	69.20	0.00e+00	797.00
IUUC-Aly-006187	Arabidopsis lyrata	40.82	3.00e-125	442.00
IUUC-Ath-007600	Arabidopsis thaliana	40.64	7.00e-125	440.00
IUUC-Ago-007900	Ashbya gossypii	26.03	1.00e-39	157.00
IUUC-Acl-008333	Aspergillus clavatus	34.30	6.00e-83	301.00
IUUC-Afl-008529	Aspergillus flavus	35.25	5.00e-88	318.00
IUUC-Afu-009071	Aspergillus fumigatus	34.65	2.00e-85	309.00
IUUC-Ani-009443	Aspergillus nidulans	33.87	2.00e-79	290.00
IUUC-Ang-009669	Aspergillus niger	34.22	1.00e-87	317.00
IUUC-Aor-009914	Aspergillus oryzae	35.12	1.00e-86	313.00
IUUC-Ate-010450	Aspergillus terreus	34.71	6.00e-86	311.00
IUUC-Bgr-012111	Blumeria graminis	31.47	1.00e-60	227.00
IUUC-Bta-012583	Bos taurus	72.02	0.00e+00	830.00
IUUC-Bci-013892	Botrytis cinerea	32.59	4.00e-65	242.00
IUUC-Bdi-014592	Brachypodium distachyon	41.44	3.00e-124	438.00
IUUC-Bol-016399	Brassica oleracea	40.82	5.00e-125	441.00
IUUC-Bra-017506	Brassica rapa	40.04	8.00e-121	427.00
IUUC-Cel-018456	Caenorhabditis elegans	36.51	1.00e-97	350.00
IUUC-Cja-020007	Callithrix jacchus	71.62	0.00e+00	825.00
IUUC-Cfa-020324	Canis familiaris	72.21	0.00e+00	833.00
IUUC-Cpo-022248	Cavia porcellus	49.81	1.00e-135	476.00
IUUC-Csa-023149	Chlorocebus sabaeus	69.47	0.00e+00	706.00
IUUC-Cho-024537	Choloepus hoffmanni	61.61	9.00e-171	593.00
IUUC-Cin-025763	Ciona intestinalis	49.15	6.00e-155	540.00
IUUC-Csv-026113	Ciona savignyi	45.56	2.00e-143	502.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.77	6.00e-64	238.00
IUUC-Cne-026884	Cryptococcus neoformans	28.76	3.00e-68	253.00
IUUC-Cme-027210	Cyanidioschyzon merolae	23.53	7.00e-19	89.00
IUUC-Dre-028140	Danio rerio	85.37	0.00e+00	980.00
IUUC-Dno-030033	Dasypus novemcinctus	70.24	0.00e+00	720.00
IUUC-Dor-030513	Dipodomys ordii	49.20	8.00e-80	290.00
IUUC-Dse-031536	Dothistroma septosporum	34.21	2.00e-84	306.00
IUUC-Dme-031683	Drosophila melanogaster	42.24	1.00e-124	440.00
IUUC-Ete-032420	Echinops telfairi	62.60	0.00e+00	678.00
IUUC-Eca-033992	Equus caballus	70.72	0.00e+00	684.00
IUUC-Eeu-034713	Erinaceus europaeus	60.24	1.00e-87	317.00
IUUC-Fca-036548	Felis catus	70.51	0.00e+00	815.00
IUUC-Fal-037600	Ficedula albicollis	71.07	0.00e+00	782.00
IUUC-Fox-038037	Fusarium oxysporum	34.58	4.00e-64	238.00
IUUC-Fso-038387	Fusarium solani	31.27	4.00e-70	258.00
IUUC-Gmo-038562	Gadus morhua	78.98	0.00e+00	903.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.03	1.00e-70	260.00
IUUC-Gga-041129	Gallus gallus	72.62	0.00e+00	807.00
IUUC-Gac-042558	Gasterosteus aculeatus	78.69	0.00e+00	910.00
IUUC-Gma-043610	Glycine max	39.37	5.00e-118	417.00
IUUC-Ggo-045611	Gorilla gorilla	71.80	0.00e+00	827.00
IUUC-Hsa-046563	Homo sapiens	72.02	0.00e+00	830.00
IUUC-Hvu-047790	Hordeum vulgare	36.78	1.00e-76	280.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	71.46	0.00e+00	822.00
IUUC-Kpa-049309	Komagataella pastoris	32.07	9.00e-73	267.00
IUUC-Lch-050038	Latimeria chalumnae	71.91	0.00e+00	823.00
IUUC-Lpe-051535	Leersia perrieri	38.83	5.00e-105	374.00
IUUC-Loc-051917	Lepisosteus oculatus	77.26	0.00e+00	860.00
IUUC-Lma-053112	Leptosphaeria maculans	34.29	8.00e-85	307.00
IUUC-Laf-053690	Loxodonta africana	72.40	0.00e+00	837.00
IUUC-Mcc-055117	Macaca mulatta	70.73	0.00e+00	818.00
IUUC-Meu-056761	Macropus eugenii	59.21	0.00e+00	649.00
IUUC-Mor-057230	Magnaporthe oryzae	32.91	1.00e-77	283.00
IUUC-Mpo-057514	Magnaporthe poae	31.73	2.00e-67	249.00
IUUC-Mtr-058551	Medicago truncatula	38.91	3.00e-115	408.00
IUUC-Mla-059183	Melampsora laricipopulina	35.33	3.00e-98	352.00
IUUC-Mga-060144	Meleagris gallopavo	71.92	0.00e+00	788.00
IUUC-Mvi-060221	Microbotryum violaceum	33.77	1.00e-79	290.00
IUUC-Mmr-061325	Microcebus murinus	70.30	0.00e+00	812.00
IUUC-Mdo-062532	Monodelphis domestica	72.78	0.00e+00	833.00
IUUC-Mmu-063956	Mus musculus	72.59	0.00e+00	833.00
IUUC-Mac-064521	Musa acuminata	38.94	5.00e-117	414.00
IUUC-Mpu-066716	Mustela putorius furo	70.42	0.00e+00	771.00
IUUC-Mlu-067459	Myotis lucifugus	72.11	0.00e+00	825.00
IUUC-Nfi-068245	Neosartorya fischeri	34.65	1.00e-85	310.00
IUUC-Ncr-068910	Neurospora crassa	33.51	2.00e-72	266.00
IUUC-Nle-070034	Nomascus leucogenys	69.64	0.00e+00	798.00
IUUC-Opr-070552	Ochotona princeps	65.31	0.00e+00	671.00
IUUC-Ont-071426	Oreochromis niloticus	82.55	0.00e+00	957.00
IUUC-Oan-073389	Ornithorhynchus anatinus	68.92	0.00e+00	640.00
IUUC-Ocu-074911	Oryctolagus cuniculus	71.64	0.00e+00	827.00
IUUC-Oba-075437	Oryza barthii	40.65	3.00e-113	402.00
IUUC-Obr-076684	Oryza brachyantha	39.81	6.00e-108	384.00
IUUC-Ogl-077170	Oryza glaberrima	40.65	3.00e-113	402.00
IUUC-Ogu-078844	Oryza glumaepatula	40.52	5.00e-105	374.00
IUUC-Oin-079105	Oryza indica	40.65	1.00e-112	400.00
IUUC-Olo-080943	Oryza longistaminata	37.63	9.00e-100	357.00
IUUC-Oni-082891	Oryza nivara	37.79	2.00e-106	379.00
IUUC-Opu-083457	Oryza punctata	40.46	6.00e-112	397.00
IUUC-Oru-084960	Oryza rufipogon	37.08	7.00e-100	357.00
IUUC-Osa-085358	Oryza sativa	40.65	3.00e-113	402.00
IUUC-Ola-086420	Oryzias latipes	79.09	0.00e+00	642.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.02	9.00e-64	237.00
IUUC-Oga-088810	Otolemur garnettii	71.64	0.00e+00	827.00
IUUC-Oar-089196	Ovis aries	71.80	0.00e+00	825.00
IUUC-Ptr-090617	Pan troglodytes	72.21	0.00e+00	832.00
IUUC-Pan-092761	Papio anubis	72.21	0.00e+00	831.00
IUUC-Psi-093191	Pelodiscus sinensis	73.89	0.00e+00	828.00
IUUC-Pma-094380	Petromyzon marinus	63.29	0.00e+00	667.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.02	3.00e-72	267.00
IUUC-Ppa-095875	Physcomitrella patens	40.26	8.00e-121	427.00
IUUC-Pfo-096467	Poecilia formosa	80.60	0.00e+00	931.00
IUUC-Pab-098255	Pongo abelii	70.18	0.00e+00	677.00
IUUC-Pop-099722	Populus trichocarpa	40.45	1.00e-122	433.00
IUUC-Pca-100807	Procavia capensis	60.75	2.00e-92	332.00
IUUC-Ppe-101280	Prunus persica	39.37	3.00e-121	428.00
IUUC-Pva-102333	Pteropus vampyrus	70.11	0.00e+00	796.00
IUUC-Pgr-103401	Puccinia graminis	29.70	8.00e-77	281.00
IUUC-Ptt-103889	Puccinia triticina	26.82	1.00e-56	214.00
IUUC-Pte-104355	Pyrenophora teres	35.36	4.00e-86	312.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.29	8.00e-87	314.00
IUUC-Rno-105810	Rattus norvegicus	71.91	0.00e+00	824.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.73	4.00e-35	142.00
IUUC-Sha-106770	Sarcophilus harrisii	73.91	2.00e-127	448.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.34	8.00e-75	274.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.65	2.00e-77	283.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.95	1.00e-70	260.00
IUUC-Smo-109296	Selaginella moellendorffii	41.21	5.00e-119	421.00
IUUC-Sit-110157	Setaria italica	41.57	7.00e-127	447.00
IUUC-Sly-111105	Solanum lycopersicum	38.69	4.00e-119	421.00
IUUC-Stu-112469	Solanum tuberosum	38.69	1.00e-119	423.00
IUUC-Sar-113083	Sorex araneus	54.26	5.00e-168	584.00
IUUC-Sbi-113813	Sorghum bicolor	41.39	2.00e-124	439.00
IUUC-Sre-115058	Sporisorium reilianum	36.24	6.00e-77	281.00
IUUC-Tgu-116772	Taeniopygia guttata	71.16	0.00e+00	790.00
IUUC-Tru-118686	Takifugu rubripes	80.49	0.00e+00	937.00
IUUC-Tsy-119111	Tarsius syrichta	68.35	8.00e-115	407.00
IUUC-Tni-120231	Tetraodon nigroviridis	73.32	0.00e+00	836.00
IUUC-Tca-121491	Theobroma cacao	38.43	4.00e-113	401.00
IUUC-Tre-122103	Trichoderma reesei	31.99	2.00e-73	270.00
IUUC-Tvi-122672	Trichoderma virens	32.78	7.00e-70	258.00
IUUC-Tae-125950	Triticum aestivum	41.63	3.00e-123	435.00
IUUC-Tur-126487	Triticum urartu	39.54	3.00e-116	412.00
IUUC-Tme-127097	Tuber melanosporum	37.75	1.00e-96	347.00
IUUC-Ttr-128465	Tursiops truncatus	67.67	0.00e+00	765.00
IUUC-Uma-129645	Ustilago maydis	35.62	1.00e-76	280.00
IUUC-Vda-129989	Verticillium dahliae	29.02	1.00e-53	204.00
IUUC-Vpa-130529	Vicugna pacos	68.61	0.00e+00	783.00
IUUC-Vvi-131059	Vitis vinifera	40.37	1.00e-119	422.00
IUUC-Xtr-132002	Xenopus tropicalis	71.10	0.00e+00	813.00
IUUC-Xma-133930	Xiphophorus maculatus	80.86	0.00e+00	935.00
IUUC-Yli-134505	Yarrowia lipolytica	31.49	2.00e-80	293.00
IUUC-Zma-135895	Zea mays	41.60	1.00e-123	436.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence