iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035999

Ensembl Protein ID

ENSFCAP00000014396.3

UniProt Accession

M3WMS6; M3WMS6_FELCA

Genbank Protein ID

ENSFCAP00000014396

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02092708

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000015524.3	ENSFCAT00000015527.3	ENSFCAP00000014396.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-11	42.5	448	498

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++lydy+++ +de ++   d+++ i  e  degW++g    +g  GlfP+n+v+ 
   Q: 448  IALYDYQGEGSDEISFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKL 498
           79**********************9..9*********..8*************85 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRAE HINIHQLRNK 60
VSEEHDILKK KEMDSGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CTGTAGTAGG GCATGATGTA TCTGTTTCTG TGGAGACCCA GGGTGATGAT 60
TGGGACACAG ACCCTGACTT TGTGGTGAGT TTGGAAATAA CTGCACTTGG AAAAATCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	88.69	0.00e+00	775.00
IUUC-Ame-011504	Astyanax mexicanus	53.75	1.00e-79	290.00
IUUC-Bta-012591	Bos taurus	86.17	0.00e+00	687.00
IUUC-Cja-019982	Callithrix jacchus	80.91	0.00e+00	681.00
IUUC-Cfa-020262	Canis familiaris	88.98	0.00e+00	696.00
IUUC-Cpo-021362	Cavia porcellus	79.56	0.00e+00	629.00
IUUC-Csa-023911	Chlorocebus sabaeus	89.39	4.00e-170	590.00
IUUC-Dor-030437	Dipodomys ordii	70.60	1.00e-166	579.00
IUUC-Dme-031931	Drosophila melanogaster	47.17	1.00e-70	261.00
IUUC-Ete-033160	Echinops telfairi	72.61	2.00e-154	538.00
IUUC-Eca-033269	Equus caballus	88.58	0.00e+00	747.00
IUUC-Eeu-035032	Erinaceus europaeus	69.73	4.00e-124	437.00
IUUC-Fal-037107	Ficedula albicollis	64.79	2.00e-105	375.00
IUUC-Gga-040335	Gallus gallus	67.14	1.00e-105	376.00
IUUC-Ggo-044505	Gorilla gorilla	78.29	0.00e+00	671.00
IUUC-Hsa-046728	Homo sapiens	88.30	3.00e-168	584.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	64.16	6.00e-161	560.00
IUUC-Lch-050221	Latimeria chalumnae	78.70	2.00e-100	359.00
IUUC-Laf-054202	Loxodonta africana	81.96	0.00e+00	674.00
IUUC-Mcc-055824	Macaca mulatta	88.58	3.00e-169	587.00
IUUC-Mmr-061281	Microcebus murinus	71.80	4.00e-165	574.00
IUUC-Mdo-062515	Monodelphis domestica	66.80	2.00e-148	518.00
IUUC-Mmu-064341	Mus musculus	81.40	0.00e+00	681.00
IUUC-Mpu-066565	Mustela putorius furo	95.72	3.00e-167	581.00
IUUC-Mlu-066942	Myotis lucifugus	85.71	0.00e+00	690.00
IUUC-Nle-069436	Nomascus leucogenys	82.60	0.00e+00	688.00
IUUC-Opr-070288	Ochotona princeps	74.30	3.00e-165	574.00
IUUC-Ont-071712	Oreochromis niloticus	74.18	1.00e-91	330.00
IUUC-Ocu-074686	Oryctolagus cuniculus	79.04	6.00e-176	610.00
IUUC-Ola-086894	Oryzias latipes	59.79	4.00e-94	338.00
IUUC-Oga-088585	Otolemur garnettii	75.35	0.00e+00	665.00
IUUC-Oar-089686	Ovis aries	85.71	0.00e+00	723.00
IUUC-Ptr-090461	Pan troglodytes	88.86	1.00e-168	585.00
IUUC-Pan-091887	Papio anubis	89.14	1.00e-170	592.00
IUUC-Psi-093785	Pelodiscus sinensis	69.26	6.00e-113	401.00
IUUC-Pfo-097391	Poecilia formosa	69.95	4.00e-90	325.00
IUUC-Pab-098222	Pongo abelii	88.30	2.00e-167	582.00
IUUC-Pca-100668	Procavia capensis	81.62	0.00e+00	682.00
IUUC-Pva-102767	Pteropus vampyrus	73.15	2.00e-169	588.00
IUUC-Rno-106001	Rattus norvegicus	80.40	0.00e+00	679.00
IUUC-Sha-106912	Sarcophilus harrisii	92.02	6.00e-116	410.00
IUUC-Sar-113338	Sorex araneus	76.22	5.00e-174	603.00
IUUC-Ssc-116027	Sus scrofa	87.37	0.00e+00	731.00
IUUC-Tgu-117472	Taeniopygia guttata	55.66	1.00e-145	509.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence