iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-53	177.1	454	492
UBD/Beta-Prp	7.30e-64	216.9	331	526

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 454  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 492
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 21   dksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..... 104
           +++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  cvh l++h+++++++++sp     
   Q: 331  NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPtgpat 419
           56778888888888888888888888888888888888888888888888888888888888888888888888888888888866666 PP
   S: 105  ....sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
               s+  l+s+s d+t+r+wd+e g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +  + ++
   Q: 420  snpnSNIMLASASFDSTVRLWDVERGVCIH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRG--TGGIFEVCWN 505
           555333678888888888888888888888.8888888888888888888888888888888888888888888887..8888888888 PP
   S: 190  sngkelvsgsldgtvklwdlq 210
             g  + + + dg+v + dl+
   Q: 506  ARGDKVGASASDGSVCVLDLR 526
           888888888888888887775 PP

Organism

Mus musculus

Functional Description
(View)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).

Protein Sequence
(Fasta)

MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQANA AAAAAAAAAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCAGTCT CGACGCTCGG GAGCGACAAG CCGCCAGCGC CCCCGCCCCG CCGCCGCTGC 60
AGCGCCCTCC GGCCGCCATT CGCCACCGAA ACTTTCCAGC GCTAGCTCTT CTCGTGGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0008022--F:protein C-terminus binding
GO:0019904--F:protein domain specific binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0007605--P:sensory perception of sound
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:21372

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	94.50	0.00e+00	995.00
IUUC-Apl-003232	Anas platyrhynchos	95.07	0.00e+00	998.00
IUUC-Aca-005035	Anolis carolinensis	94.88	0.00e+00	999.00
IUUC-Bta-013202	Bos taurus	96.97	0.00e+00	1009.00
IUUC-Cja-019281	Callithrix jacchus	91.27	0.00e+00	973.00
IUUC-Cfa-020929	Canis familiaris	96.77	0.00e+00	1005.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	61.71	9.00e-132	463.00
IUUC-Csa-023943	Chlorocebus sabaeus	92.60	0.00e+00	983.00
IUUC-Cin-025704	Ciona intestinalis	72.59	0.00e+00	791.00
IUUC-Cne-026946	Cryptococcus neoformans	38.01	1.00e-30	128.00
IUUC-Dno-028926	Dasypus novemcinctus	96.02	0.00e+00	1002.00
IUUC-Dme-031939	Drosophila melanogaster	82.02	2.00e-176	612.00
IUUC-Ete-032822	Echinops telfairi	83.30	0.00e+00	845.00
IUUC-Eca-033897	Equus caballus	97.15	0.00e+00	1009.00
IUUC-Fca-036462	Felis catus	97.53	0.00e+00	1011.00
IUUC-Fal-037388	Ficedula albicollis	95.64	0.00e+00	1001.00
IUUC-Gga-040671	Gallus gallus	95.83	0.00e+00	1001.00
IUUC-Gac-041851	Gasterosteus aculeatus	89.56	0.00e+00	935.00
IUUC-Ggo-045373	Gorilla gorilla	94.31	0.00e+00	991.00
IUUC-Hsa-045841	Homo sapiens	93.93	0.00e+00	986.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	99.19	0.00e+00	780.00
IUUC-Lch-050535	Latimeria chalumnae	91.27	0.00e+00	979.00
IUUC-Laf-054071	Loxodonta africana	96.79	0.00e+00	1004.00
IUUC-Mcc-055233	Macaca mulatta	92.50	0.00e+00	967.00
IUUC-Mga-059895	Meleagris gallopavo	95.45	0.00e+00	1001.00
IUUC-Mvi-060557	Microbotryum violaceum	37.30	3.00e-70	259.00
IUUC-Mmr-061286	Microcebus murinus	96.23	0.00e+00	1008.00
IUUC-Nle-069151	Nomascus leucogenys	93.17	0.00e+00	981.00
IUUC-Ont-072252	Oreochromis niloticus	89.75	0.00e+00	959.00
IUUC-Oan-073562	Ornithorhynchus anatinus	97.34	0.00e+00	1011.00
IUUC-Oar-089506	Ovis aries	94.88	0.00e+00	1009.00
IUUC-Ptr-090793	Pan troglodytes	91.46	0.00e+00	948.00
IUUC-Pan-091909	Papio anubis	93.40	0.00e+00	985.00
IUUC-Psi-093358	Pelodiscus sinensis	92.00	0.00e+00	958.00
IUUC-Pfo-097214	Poecilia formosa	88.05	0.00e+00	923.00
IUUC-Pab-098317	Pongo abelii	93.42	0.00e+00	964.00
IUUC-Pop-098989	Populus trichocarpa	57.89	4.00e-129	454.00
IUUC-Rno-105857	Rattus norvegicus	100.00	0.00e+00	1016.00
IUUC-Sha-107326	Sarcophilus harrisii	94.12	0.00e+00	1009.00
IUUC-Ssc-115646	Sus scrofa	97.35	0.00e+00	1011.00
IUUC-Tgu-116898	Taeniopygia guttata	95.26	0.00e+00	1000.00
IUUC-Tru-117862	Takifugu rubripes	89.75	0.00e+00	946.00
IUUC-Tni-119656	Tetraodon nigroviridis	89.94	0.00e+00	946.00
IUUC-Ttr-128826	Tursiops truncatus	95.67	0.00e+00	922.00
IUUC-Vvi-131193	Vitis vinifera	57.14	2.00e-129	456.00
IUUC-Xma-133591	Xiphophorus maculatus	88.24	0.00e+00	926.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence