iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044535

UUCD1 version

UUC-GoG-00878

Ensembl Protein ID

ENSGGOP00000024193.1

UniProt Accession

G3S7Y3; G3S7Y3_GORGO

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007233.2	ENSGGOT00000023524.1	ENSGGOP00000024193.1
ENSGGOG00000007233.2	ENSGGOT00000007270.2	ENSGGOP00000007084.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.40e-136	453.2	540	872

Active Site

Position(s)	Description	Evidence
841	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 540  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 627
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee++l++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 628  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 713
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 714  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFV 801
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 802  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 872
           *********************************************************************96 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

CHVQVFQPIG GMSDGGSQLG SMGSLTMKSQ LQITVISAKL KENKKNWFGP SPYVEVTVDG 60
QSKKTEKCNN TNSPKWKQPL TVIVTPVSKL HFRVWSHQTL KSDVLLGTAA LDIYETLKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCATGTTC AGGTTTTCCA ACCTATTGGT GGTATGTCTG ACGGTGGATC ACAACTTGGT 60
TCAATGGGTA GCCTCACCAT GAAATCACAG CTTCAGATCA CTGGTAAGTT TTAGAAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	93.12	0.00e+00	1562.00
IUUC-Apl-003752	Anas platyrhynchos	80.97	0.00e+00	1398.00
IUUC-Aca-005338	Anolis carolinensis	78.67	0.00e+00	1378.00
IUUC-Ame-010601	Astyanax mexicanus	85.01	0.00e+00	1084.00
IUUC-Bta-012782	Bos taurus	93.27	0.00e+00	1524.00
IUUC-Cja-018899	Callithrix jacchus	90.43	0.00e+00	1521.00
IUUC-Cfa-020648	Canis familiaris	92.11	0.00e+00	1531.00
IUUC-Cpo-022073	Cavia porcellus	94.08	0.00e+00	1578.00
IUUC-Csa-023252	Chlorocebus sabaeus	94.43	0.00e+00	1589.00
IUUC-Cho-024695	Choloepus hoffmanni	86.71	0.00e+00	1554.00
IUUC-Dre-028451	Danio rerio	73.12	0.00e+00	1259.00
IUUC-Dno-029884	Dasypus novemcinctus	93.39	0.00e+00	1611.00
IUUC-Eca-033793	Equus caballus	93.59	0.00e+00	1598.00
IUUC-Eeu-034716	Erinaceus europaeus	88.21	0.00e+00	841.00
IUUC-Fca-035605	Felis catus	93.28	0.00e+00	1583.00
IUUC-Fal-037126	Ficedula albicollis	80.61	0.00e+00	1392.00
IUUC-Gmo-038596	Gadus morhua	77.47	0.00e+00	972.00
IUUC-Gga-040832	Gallus gallus	81.27	0.00e+00	1407.00
IUUC-Gac-041520	Gasterosteus aculeatus	84.94	0.00e+00	1077.00
IUUC-Hsa-046564	Homo sapiens	91.69	0.00e+00	1593.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	93.33	0.00e+00	1512.00
IUUC-Lch-050454	Latimeria chalumnae	74.23	0.00e+00	1332.00
IUUC-Loc-052647	Lepisosteus oculatus	72.34	0.00e+00	1308.00
IUUC-Laf-054383	Loxodonta africana	94.45	0.00e+00	1596.00
IUUC-Mcc-055532	Macaca mulatta	94.66	0.00e+00	1591.00
IUUC-Mga-059661	Meleagris gallopavo	80.90	0.00e+00	1404.00
IUUC-Mmr-061135	Microcebus murinus	94.08	0.00e+00	1605.00
IUUC-Mdo-062505	Monodelphis domestica	83.56	0.00e+00	1449.00
IUUC-Mmu-063375	Mus musculus	92.36	0.00e+00	1536.00
IUUC-Mpu-066203	Mustela putorius furo	93.87	0.00e+00	1559.00
IUUC-Mlu-067837	Myotis lucifugus	93.36	0.00e+00	1597.00
IUUC-Nle-069244	Nomascus leucogenys	93.87	0.00e+00	1571.00
IUUC-Opr-070585	Ochotona princeps	87.49	0.00e+00	1516.00
IUUC-Ont-071822	Oreochromis niloticus	70.74	0.00e+00	1286.00
IUUC-Ocu-074298	Oryctolagus cuniculus	93.87	0.00e+00	1566.00
IUUC-Ola-086526	Oryzias latipes	83.08	0.00e+00	1084.00
IUUC-Oga-088167	Otolemur garnettii	87.02	0.00e+00	1453.00
IUUC-Oar-090316	Ovis aries	76.94	0.00e+00	1142.00
IUUC-Ptr-090819	Pan troglodytes	90.80	0.00e+00	1553.00
IUUC-Pan-092454	Papio anubis	94.71	0.00e+00	1607.00
IUUC-Psi-093319	Pelodiscus sinensis	78.76	0.00e+00	1365.00
IUUC-Pfo-097346	Poecilia formosa	81.05	0.00e+00	1061.00
IUUC-Pab-097580	Pongo abelii	84.50	0.00e+00	1423.00
IUUC-Pca-100923	Procavia capensis	75.75	0.00e+00	1298.00
IUUC-Pva-103209	Pteropus vampyrus	92.34	0.00e+00	1523.00
IUUC-Rno-104924	Rattus norvegicus	90.99	0.00e+00	1545.00
IUUC-Sha-107175	Sarcophilus harrisii	85.60	0.00e+00	1449.00
IUUC-Sar-113761	Sorex araneus	83.62	0.00e+00	1432.00
IUUC-Tgu-116632	Taeniopygia guttata	77.14	0.00e+00	1269.00
IUUC-Tru-118442	Takifugu rubripes	85.99	0.00e+00	1084.00
IUUC-Tsy-119198	Tarsius syrichta	87.24	0.00e+00	1465.00
IUUC-Tni-120168	Tetraodon nigroviridis	83.51	0.00e+00	1019.00
IUUC-Tbe-127756	Tupaia belangeri	74.64	0.00e+00	1246.00
IUUC-Ttr-128504	Tursiops truncatus	87.09	0.00e+00	1133.00
IUUC-Vpa-130103	Vicugna pacos	79.20	0.00e+00	1331.00
IUUC-Xtr-132885	Xenopus tropicalis	73.48	0.00e+00	1316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence