iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063150

Ensembl Protein ID

ENSMUSP00000034270.9

UniProt Accession

Q9CQV6; Q3U9W5; Q9D1R0; MLP3B_MOUSE

Genbank Protein ID

AAL83723.1; BAB22364.1; BAB22569.1; BAB22641.1; BAB22855.1; BAB28350.1; BAE21108.1; BAE30551.1; AAH68180.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta

Genbank Nucleotide ID

AF255953; AK002795; AK003106; AK003205; AK003558; AK012604; AK132329; AK151614; BC068180

Gene Name

Map1lc3b; Map1alc3; Map1lc3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031812.16	ENSMUST00000034270.16	ENSMUSP00000034270.9
ENSMUSG00000031812.16	ENSMUST00000181826.1	ENSMUSP00000148359.1
ENSMUSG00000031812.16	ENSMUST00000181948.1	ENSMUSP00000137754.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	3.50e-48	163.2	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeek 87
           +r+e+v+ ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++l+kiir+rlql+a++a+fllvn  s+vsvs++++e+ye+e+
   Q: 15   QRVEDVRLIREQHPTKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGhSMVSVSTPISEVYESER 103
           699*************************99****************************************99***************** PP
   S: 88   dedgflyvayaseetfG 104
           dedgfly++yas+etfG
   Q: 104  DEDGFLYMVYASQETFG 120
           ****************9 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Protein Sequence
(Fasta)

MPSEKTFKQR RSFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SERDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGAGCTTC CGCCACGCCT GTCATGGCCG CTCTCGGGGG CCGCCCTCGG CCCCACCCTC 60
GGTGACGCGC CGCGAGTCAC CTGACTCGGC TGCGGACTGA GACACACACA AGGGAAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0031410--C:cytoplasmic vesicle
GO:0012505--C:endomembrane system
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005739--C:mitochondrion
GO:0031625--F:ubiquitin protein ligase binding
GO:0006914--P:autophagy
GO:0070257--P:positive regulation of mucus secretion
GO:1903146--P:regulation of mitophagy

KEGG

mmu:67443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001523	Ailuropoda melanoleuca	93.65	1.00e-65	241.00
IUUC-Apl-004007	Anas platyrhynchos	89.08	6.00e-59	218.00
IUUC-Aca-004678	Anolis carolinensis	93.10	6.00e-61	226.00
IUUC-Bta-013149	Bos taurus	94.40	2.00e-67	246.00
IUUC-Cja-019405	Callithrix jacchus	95.20	9.00e-68	248.00
IUUC-Cfa-020120	Canis familiaris	94.44	6.00e-66	242.00
IUUC-Cpo-021922	Cavia porcellus	95.97	4.00e-67	246.00
IUUC-Csa-023961	Chlorocebus sabaeus	95.20	9.00e-68	248.00
IUUC-Cho-024909	Choloepus hoffmanni	86.36	6.00e-52	195.00
IUUC-Cin-025249	Ciona intestinalis	76.86	4.00e-54	202.00
IUUC-Csv-026146	Ciona savignyi	50.00	6.00e-31	125.00
IUUC-Dre-028586	Danio rerio	95.00	1.00e-64	237.00
IUUC-Dno-029506	Dasypus novemcinctus	95.20	5.00e-67	246.00
IUUC-Dor-030793	Dipodomys ordii	93.60	3.00e-67	246.00
IUUC-Ete-032996	Echinops telfairi	96.36	1.00e-58	217.00
IUUC-Eca-034195	Equus caballus	94.40	4.00e-67	246.00
IUUC-Fca-035717	Felis catus	93.81	8.00e-58	214.00
IUUC-Fal-037169	Ficedula albicollis	85.48	5.00e-60	222.00
IUUC-Gmo-038732	Gadus morhua	87.20	1.00e-63	234.00
IUUC-Gga-041131	Gallus gallus	92.80	3.00e-66	243.00
IUUC-Gac-041441	Gasterosteus aculeatus	91.74	6.00e-64	235.00
IUUC-Ggo-044417	Gorilla gorilla	95.50	1.00e-59	221.00
IUUC-Hsa-046160	Homo sapiens	95.20	9.00e-68	248.00
IUUC-Itr-048601	Ictidomys tridecemlineatus	93.75	6.00e-58	215.00
IUUC-Lch-050631	Latimeria chalumnae	92.00	1.00e-65	241.00
IUUC-Loc-052865	Lepisosteus oculatus	91.20	2.00e-65	239.00
IUUC-Laf-053756	Loxodonta africana	94.44	6.00e-66	242.00
IUUC-Mcc-054698	Macaca mulatta	95.20	9.00e-68	248.00
IUUC-Meu-056702	Macropus eugenii	83.20	2.00e-57	213.00
IUUC-Mga-059558	Meleagris gallopavo	86.40	1.00e-60	224.00
IUUC-Mdo-062675	Monodelphis domestica	95.20	2.00e-67	247.00
IUUC-Mpu-066210	Mustela putorius furo	88.80	5.00e-62	229.00
IUUC-Mlu-067216	Myotis lucifugus	90.76	1.00e-59	221.00
IUUC-Nle-069962	Nomascus leucogenys	95.20	9.00e-68	248.00
IUUC-Opr-070758	Ochotona princeps	99.06	6.00e-59	218.00
IUUC-Ont-072582	Oreochromis niloticus	92.62	2.00e-64	236.00
IUUC-Oan-072816	Ornithorhynchus anatinus	89.43	3.00e-60	223.00
IUUC-Ocu-073918	Oryctolagus cuniculus	88.52	2.00e-58	217.00
IUUC-Oga-088260	Otolemur garnettii	95.20	2.00e-67	247.00
IUUC-Oar-090154	Ovis aries	94.40	2.00e-67	246.00
IUUC-Ptr-091009	Pan troglodytes	95.20	9.00e-68	248.00
IUUC-Pan-091694	Papio anubis	95.20	9.00e-68	248.00
IUUC-Psi-093327	Pelodiscus sinensis	92.86	2.00e-58	216.00
IUUC-Pma-094489	Petromyzon marinus	85.00	5.00e-58	215.00
IUUC-Pfo-096338	Poecilia formosa	89.17	6.00e-61	225.00
IUUC-Pab-098381	Pongo abelii	95.93	3.00e-67	246.00
IUUC-Pca-100621	Procavia capensis	94.40	5.00e-67	245.00
IUUC-Pva-102563	Pteropus vampyrus	94.40	3.00e-67	246.00
IUUC-Rno-106063	Rattus norvegicus	99.20	2.00e-70	257.00
IUUC-Sha-107561	Sarcophilus harrisii	95.54	8.00e-60	222.00
IUUC-Sar-113048	Sorex araneus	95.51	8.00e-47	177.00
IUUC-Ssc-116253	Sus scrofa	94.40	2.00e-67	246.00
IUUC-Tgu-117120	Taeniopygia guttata	92.00	5.00e-66	242.00
IUUC-Tru-118140	Takifugu rubripes	94.17	4.00e-64	236.00
IUUC-Tsy-118793	Tarsius syrichta	94.59	5.00e-59	218.00
IUUC-Tbe-127594	Tupaia belangeri	94.59	9.00e-59	218.00
IUUC-Ttr-128932	Tursiops truncatus	94.40	2.00e-67	246.00
IUUC-Vpa-130747	Vicugna pacos	94.59	2.00e-59	219.00
IUUC-Xtr-132757	Xenopus tropicalis	94.35	5.00e-66	242.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence