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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046708
UUCD1 version UUC-HoS-00768
Ensembl Protein ID ENSP00000280190.4
UniProt Accession Q8IZU2; E7EQX0; Q0QD35; WDR17_HUMAN
Genbank Protein ID AAN64030.1; ABD90546.1; ABD90547.1
Protein Name WD repeat-containing protein 17
Genbank Nucleotide ID AF492460; AC093605; DQ426896
Gene Name WDR17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000150627.15 ENST00000508596.5 ENSP00000422763.1
ENSG00000150627.15 ENST00000280190.8 ENSP00000280190.4
ENSG00000150627.15 ENST00000507824.6 ENSP00000422200.2
ENSG00000150627.15 ENST00000513261.1 ENSP00000427502.1
ENSG00000150627.15 ENST00000505894.2 ENSP00000426847.2
ENSG00000150627.15 ENST00000443118.3 ENSP00000426985.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDMentha
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.40e-53 176.2 607 646
UBD/Beta-Prp 1.30e-67 229.7 518 683
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v++l + ++   ll+sGs+D tikvWD+r+g+++ 
   Q: 607  GHTAPVRGLMWnTEipYLLISGSWDYTIKVWDTREGTCVD 646
           8**********85573668******************986 PP
   

   UBD/Beta-Prp
   S: 49   sgheaevtavkfspdgk.ilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqcleetlsgh 136
           ++h a+v  +++s++ k +++tg eD +++v+    s+ +++ +++gh+++v  +++sp     l sGs+d t+r+wd  ++ c++ +l+gh
   Q: 518  YKHPAAVFGCDWSQNNKdMIATGCEDTNVRVYyvATSSDQPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWDYTQDACIN-ILNGH 608
           67888888888887766688888888888888777778888888888888888888888555888888888888888888888888.88888 PP
   S: 137  dgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq 210
           ++ v+++ ++ +   ll+sGs D t+++Wd + g++++t    h  +vy l+ ++++ + ++s+s+d+tv+lw+l 
   Q: 609  TAPVRGLMWNTEIpYLLISGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRpFTMASCSRDSTVRLWSLT 683
           888888888888888888888888888888888888888876.888888888888877888888888888888874 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG DRFAYCATLA 60
IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA SGSTDNLVII WNVAEQKVIA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046708|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTCTGGGG CAGACCCTGG AGATCGGGCT CGCGGCGCCT TCCATCGTGG CTCCGCGCTG 60
GGGCTTGCGG AGCACGCTTC CCGCCCCTCG GAGCCCGCGG GCCCGGCCGC CCCGCCCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046708|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
KEGG hsa:116966
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001190 Ailuropoda melanoleuca 90.85 0.00e+00 2487.00
IUUC-Apl-003326 Anas platyrhynchos 84.72 0.00e+00 2301.00
IUUC-Aca-004349 Anolis carolinensis 84.30 0.00e+00 2288.00
IUUC-Ame-011366 Astyanax mexicanus 60.36 0.00e+00 1482.00
IUUC-Bta-013275 Bos taurus 90.69 0.00e+00 2476.00
IUUC-Cja-018970 Callithrix jacchus 95.84 0.00e+00 2645.00
IUUC-Cfa-021237 Canis familiaris 91.09 0.00e+00 2539.00
IUUC-Cpo-021342 Cavia porcellus 86.05 0.00e+00 1660.00
IUUC-Cre-022569 Chlamydomonas reinhardtii 28.67 7.00e-81 295.00
IUUC-Csa-023687 Chlorocebus sabaeus 97.05 0.00e+00 2675.00
IUUC-Cho-024772 Choloepus hoffmanni 79.43 0.00e+00 799.00
IUUC-Csv-026021 Ciona savignyi 40.88 0.00e+00 1026.00
IUUC-Dre-028031 Danio rerio 80.25 0.00e+00 2187.00
IUUC-Dno-029369 Dasypus novemcinctus 86.60 0.00e+00 2279.00
IUUC-Dor-030645 Dipodomys ordii 88.88 0.00e+00 2460.00
IUUC-Ete-032530 Echinops telfairi 85.48 0.00e+00 2345.00
IUUC-Eca-034405 Equus caballus 90.92 0.00e+00 2490.00
IUUC-Eeu-035006 Erinaceus europaeus 86.59 0.00e+00 1085.00
IUUC-Fca-035965 Felis catus 90.01 0.00e+00 2452.00
IUUC-Fal-037136 Ficedula albicollis 83.47 0.00e+00 2289.00
IUUC-Gmo-039293 Gadus morhua 75.16 0.00e+00 1962.00
IUUC-Gga-040931 Gallus gallus 81.86 0.00e+00 2251.00
IUUC-Gac-042493 Gasterosteus aculeatus 74.85 0.00e+00 2013.00
IUUC-Ggo-045540 Gorilla gorilla 98.54 0.00e+00 2650.00
IUUC-Lch-050135 Latimeria chalumnae 82.17 0.00e+00 1724.00
IUUC-Loc-051730 Lepisosteus oculatus 84.17 0.00e+00 2295.00
IUUC-Laf-053743 Loxodonta africana 91.15 0.00e+00 2463.00
IUUC-Mcc-055590 Macaca mulatta 96.90 0.00e+00 2672.00
IUUC-Meu-056328 Macropus eugenii 67.20 0.00e+00 1672.00
IUUC-Mga-059877 Meleagris gallopavo 80.94 0.00e+00 2197.00
IUUC-Mmr-060756 Microcebus murinus 93.57 0.00e+00 2590.00
IUUC-Mdo-062749 Monodelphis domestica 84.67 0.00e+00 2330.00
IUUC-Mmu-063668 Mus musculus 88.35 0.00e+00 2471.00
IUUC-Mpu-066856 Mustela putorius furo 90.47 0.00e+00 2495.00
IUUC-Mlu-067186 Myotis lucifugus 84.82 0.00e+00 2325.00
IUUC-Nle-070018 Nomascus leucogenys 98.23 0.00e+00 2665.00
IUUC-Ont-071482 Oreochromis niloticus 69.99 0.00e+00 1859.00
IUUC-Oan-073065 Ornithorhynchus anatinus 83.46 0.00e+00 1795.00
IUUC-Ocu-073786 Oryctolagus cuniculus 91.77 0.00e+00 2484.00
IUUC-Oga-088545 Otolemur garnettii 87.44 0.00e+00 2415.00
IUUC-Oar-090205 Ovis aries 88.89 0.00e+00 2492.00
IUUC-Ptr-091092 Pan troglodytes 99.47 0.00e+00 2739.00
IUUC-Pan-092430 Papio anubis 96.97 0.00e+00 2672.00
IUUC-Psi-093774 Pelodiscus sinensis 85.40 0.00e+00 2320.00
IUUC-Pfo-097414 Poecilia formosa 74.39 0.00e+00 1957.00
IUUC-Pab-097853 Pongo abelii 98.71 0.00e+00 2722.00
IUUC-Pca-100440 Procavia capensis 76.98 0.00e+00 805.00
IUUC-Pva-102838 Pteropus vampyrus 90.62 0.00e+00 2513.00
IUUC-Rno-104951 Rattus norvegicus 86.01 0.00e+00 2393.00
IUUC-Sha-107508 Sarcophilus harrisii 84.64 0.00e+00 2336.00
IUUC-Sar-113549 Sorex araneus 87.63 0.00e+00 1602.00
IUUC-Ssc-115753 Sus scrofa 90.72 0.00e+00 1952.00
IUUC-Tgu-117315 Taeniopygia guttata 83.45 0.00e+00 2274.00
IUUC-Tru-118153 Takifugu rubripes 74.58 0.00e+00 1996.00
IUUC-Tsy-119384 Tarsius syrichta 86.26 0.00e+00 2371.00
IUUC-Tni-120820 Tetraodon nigroviridis 78.24 5.00e-105 373.00
IUUC-Tbe-127579 Tupaia belangeri 80.60 0.00e+00 1089.00
IUUC-Ttr-128488 Tursiops truncatus 84.19 0.00e+00 2323.00
IUUC-Vpa-130274 Vicugna pacos 84.89 0.00e+00 1058.00
IUUC-Xtr-132199 Xenopus tropicalis 84.88 0.00e+00 2325.00
Created Date 25-Jun-2017

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