iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.80e-07	29.0	106	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGs....dDgtikvWDlrtgvll 36
           tcla+   d ++l+ G     +D  i +WD+ +gv+ 
   Q: 106  TCLAWneLDaNILAIGHdrhrNDTCITIWDIERGVPK 142
           89***99888999999999988888*****9999875 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Involved in the differentiation of the oocyte nucleus. Influences meiotic progression prior to pachytene and possibly by interacting with pathways that control DNA metabolism. May act in the oocyte nucleus to facilitate the execution of the unique cell cycle and developmental programs that produce the mature haploid gamete. Required for the regulation of the TORC1 pathway by amino acids.

Protein Sequence
(Fasta)

MSGNTHGLSW FPHFPDKFVS WGQEIHLYEV RRKDDHSQKS RLPYISVNYL ANESRYQYAR 60
CVAASYHSDQ PIIAVGLADG KVGICNFRDT YDSSWEYTPR QQRMCTCLAW NELDANILAI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGTGTGTG CGCCTCTTCT TCTTGCCATG TAGTGCAGTG TTTATCTCAC GTTTTTGTTT 60
TTGCAAACTG ATAACGCGAC GCAATTTAGT CTGTAGTGAA AATTGTTTTT TTTTACATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0539--Nucleus
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR031488--Zn_ribbon_mio
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF00400--WD40
PF17034--zinc_ribbon_16

SMART

SM00320--WD40

Gene Ontology

GO:0044754--C:autolysosome
GO:0001674--C:female germ cell nucleus
GO:0061700--C:GATOR2 complex
GO:0005764--C:lysosome
GO:0043234--C:protein complex
GO:0035859--C:Seh1-associated complex
GO:0034198--P:cellular response to amino acid starvation
GO:0006302--P:double-strand break repair
GO:0007293--P:germarium-derived egg chamber formation
GO:0007275--P:multicellular organism development
GO:0010507--P:negative regulation of autophagy
GO:0009994--P:oocyte differentiation
GO:0030716--P:oocyte fate determination
GO:0045793--P:positive regulation of cell size
GO:0032008--P:positive regulation of TOR signaling
GO:0040020--P:regulation of meiotic nuclear division
GO:1903432--P:regulation of TORC1 signaling

KEGG

dme:Dmel_CG7074

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001544	Ailuropoda melanoleuca	31.24	1.00e-122	433.00
IUUC-Apl-003888	Anas platyrhynchos	31.64	8.00e-125	440.00
IUUC-Aca-004555	Anolis carolinensis	31.14	3.00e-122	432.00
IUUC-Acl-008325	Aspergillus clavatus	26.80	3.00e-33	136.00
IUUC-Afl-008515	Aspergillus flavus	25.97	2.00e-36	147.00
IUUC-Afu-008938	Aspergillus fumigatus	26.15	2.00e-37	150.00
IUUC-Ani-009434	Aspergillus nidulans	26.03	9.00e-34	138.00
IUUC-Ang-009607	Aspergillus niger	25.78	2.00e-37	150.00
IUUC-Ate-010488	Aspergillus terreus	25.39	6.00e-36	145.00
IUUC-Ame-011575	Astyanax mexicanus	31.82	7.00e-123	434.00
IUUC-Bta-012439	Bos taurus	31.42	3.00e-122	432.00
IUUC-Cja-019416	Callithrix jacchus	31.53	3.00e-121	428.00
IUUC-Cfa-020502	Canis familiaris	31.64	2.00e-123	436.00
IUUC-Cpo-021505	Cavia porcellus	31.53	2.00e-123	436.00
IUUC-Csa-023741	Chlorocebus sabaeus	31.64	2.00e-123	436.00
IUUC-Cho-024318	Choloepus hoffmanni	42.46	2.00e-40	160.00
IUUC-Cne-026795	Cryptococcus neoformans	27.37	9.00e-08	52.00
IUUC-Dre-028717	Danio rerio	27.78	9.00e-84	303.00
IUUC-Dno-029671	Dasypus novemcinctus	30.93	1.00e-122	433.00
IUUC-Dor-030959	Dipodomys ordii	31.42	4.00e-122	431.00
IUUC-Ete-032566	Echinops telfairi	31.49	3.00e-124	438.00
IUUC-Eca-033468	Equus caballus	31.53	1.00e-122	433.00
IUUC-Eeu-034980	Erinaceus europaeus	30.07	6.00e-116	410.00
IUUC-Fca-035591	Felis catus	31.42	2.00e-122	432.00
IUUC-Fal-036655	Ficedula albicollis	31.47	7.00e-124	437.00
IUUC-Gmo-039467	Gadus morhua	38.87	4.00e-76	278.00
IUUC-Gac-041898	Gasterosteus aculeatus	31.16	1.00e-121	429.00
IUUC-Ggo-045602	Gorilla gorilla	31.64	2.00e-123	436.00
IUUC-Hsa-045989	Homo sapiens	31.64	1.00e-123	436.00
IUUC-Itr-048336	Ictidomys tridecemlineatus	31.45	3.00e-123	435.00
IUUC-Lch-049432	Latimeria chalumnae	30.98	7.00e-123	434.00
IUUC-Loc-051863	Lepisosteus oculatus	30.69	3.00e-118	418.00
IUUC-Laf-053630	Loxodonta africana	31.34	1.00e-122	433.00
IUUC-Mcc-054913	Macaca mulatta	31.14	9.00e-119	420.00
IUUC-Mla-058875	Melampsora laricipopulina	24.86	1.00e-14	75.10
IUUC-Mga-059331	Meleagris gallopavo	31.75	2.00e-125	442.00
IUUC-Mvi-060377	Microbotryum violaceum	27.57	6.00e-35	142.00
IUUC-Mmr-061068	Microcebus murinus	31.57	2.00e-123	436.00
IUUC-Mmu-064181	Mus musculus	31.53	4.00e-123	435.00
IUUC-Mpu-065818	Mustela putorius furo	31.24	9.00e-123	433.00
IUUC-Mlu-067027	Myotis lucifugus	30.85	8.00e-122	430.00
IUUC-Nfi-068460	Neosartorya fischeri	25.64	1.00e-37	150.00
IUUC-Nle-069884	Nomascus leucogenys	31.74	1.00e-123	436.00
IUUC-Opr-070764	Ochotona princeps	30.02	1.00e-101	363.00
IUUC-Ont-071473	Oreochromis niloticus	29.92	6.00e-120	424.00
IUUC-Ocu-074541	Oryctolagus cuniculus	31.34	4.00e-121	428.00
IUUC-Ola-086342	Oryzias latipes	31.82	5.00e-112	397.00
IUUC-Oga-089081	Otolemur garnettii	31.74	2.00e-123	436.00
IUUC-Oar-089969	Ovis aries	31.64	2.00e-123	436.00
IUUC-Ptr-091278	Pan troglodytes	31.64	1.00e-123	436.00
IUUC-Pan-092315	Papio anubis	30.87	5.00e-105	375.00
IUUC-Psi-093799	Pelodiscus sinensis	31.37	2.00e-124	439.00
IUUC-Pno-094978	Phaeosphaeria nodorum	24.07	6.00e-18	85.90
IUUC-Pfo-096693	Poecilia formosa	31.14	4.00e-120	425.00
IUUC-Pab-097903	Pongo abelii	31.64	4.00e-123	434.00
IUUC-Pca-100325	Procavia capensis	27.11	3.00e-40	159.00
IUUC-Pgr-103692	Puccinia graminis	24.91	9.00e-16	79.00
IUUC-Rno-105936	Rattus norvegicus	31.42	2.00e-122	432.00
IUUC-Spo-108350	Schizosaccharomyces pombe	29.90	1.00e-43	171.00
IUUC-Sar-113246	Sorex araneus	31.17	1.00e-122	433.00
IUUC-Ssc-115759	Sus scrofa	30.81	1.00e-104	373.00
IUUC-Tgu-116985	Taeniopygia guttata	31.50	3.00e-124	438.00
IUUC-Tru-118524	Takifugu rubripes	31.42	7.00e-122	430.00
IUUC-Tsy-119545	Tarsius syrichta	31.53	5.00e-123	434.00
IUUC-Tni-120566	Tetraodon nigroviridis	31.64	5.00e-121	427.00
IUUC-Tbe-127649	Tupaia belangeri	41.15	1.00e-59	223.00
IUUC-Ttr-128308	Tursiops truncatus	40.32	2.00e-70	259.00
IUUC-Xtr-132955	Xenopus tropicalis	30.99	1.00e-123	436.00
IUUC-Xma-133519	Xiphophorus maculatus	30.43	1.00e-119	423.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence