iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064278

UUCD1 version

UUC-MuM-01028

Ensembl Protein ID

ENSMUSP00000112820.1

UniProt Accession

Q9WTV7; Q8CE02; Q91X19; Q9CYY2; RNF12_MOUSE

Genbank Protein ID

AAD34209.1; BAB28712.1; BAC26379.1; CAM26768.1; EDL14089.1; EDL14090.1; AAH12960.1

Protein Name

E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; RING finger LIM domain-binding protein; RING finger protein 12; RING-type E3 ubiquitin transferase RLIM

Genbank Nucleotide ID

AF069992; AK013207; AK029295; AL805911; CH466564; CH466564; BC012960

Gene Name

Rlim; Rnf12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000056537.11	ENSMUST00000121153.7	ENSMUSP00000112820.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.40e-07	30.7	546	587

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C +++ +g  ++ lpC H +h +C+ +w       s + +CP+Cr
   Q: 546  CSVCITEYTEGnkLRKLPCSHEYHVHCIDRW------LSENSTCPICR 587
           9*******5554499****************......**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Protein Sequence
(Fasta)

MENSDSNDKG SDQSAAQRRS QMDRLDREEA FYQFVNNLSE EDYRLMRDNN LLGTPGESTE 60
EELLRRLQQI KEGPPPQSPD ENRAGESSDD VTNSDSIIDW LNSVRQTGNT TRSGQRGNQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCAGTCAT TTCCTGTCAG TGCTAGGTAA CAATGGGGAA GATAATGGCT GATTGAGCTA 60
CGTCTCCGAG CTGGCGCTGT TCTAGAGGCG GGTCTCTTGC CCGGGTTTAG AGGCGGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0060816--P:random inactivation of X chromosome
GO:1900095--P:regulation of dosage compensation by inactivation of X chromosome
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:19820

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000316	Aegilops tauschii	42.37	6.00e-10	57.00
IUUC-Aml-001407	Ailuropoda melanoleuca	86.43	4.00e-174	604.00
IUUC-Atr-002539	Amborella trichopoda	46.43	1.00e-14	74.30
IUUC-Apl-003969	Anas platyrhynchos	71.80	0.00e+00	715.00
IUUC-Aca-005377	Anolis carolinensis	67.72	1.00e-133	470.00
IUUC-Aly-005870	Arabidopsis lyrata	42.70	3.00e-16	79.30
IUUC-Ath-006611	Arabidopsis thaliana	42.11	5.00e-16	78.60
IUUC-Bta-013113	Bos taurus	86.02	9.00e-177	613.00
IUUC-Bdi-014392	Brachypodium distachyon	47.06	3.00e-14	72.00
IUUC-Bol-015085	Brassica oleracea	43.01	3.00e-16	79.30
IUUC-Bra-017624	Brassica rapa	43.01	3.00e-16	79.30
IUUC-Cja-018860	Callithrix jacchus	84.93	2.00e-170	592.00
IUUC-Cfa-020358	Canis familiaris	86.20	2.00e-170	592.00
IUUC-Cpo-021533	Cavia porcellus	84.60	4.00e-155	540.00
IUUC-Cre-022755	Chlamydomonas reinhardtii	44.68	1.00e-13	67.40
IUUC-Csa-023242	Chlorocebus sabaeus	84.13	2.00e-160	559.00
IUUC-Cho-024536	Choloepus hoffmanni	78.09	1.00e-145	509.00
IUUC-Dno-029606	Dasypus novemcinctus	87.44	0.00e+00	652.00
IUUC-Dor-031042	Dipodomys ordii	80.73	2.00e-163	568.00
IUUC-Ete-033099	Echinops telfairi	82.43	0.00e+00	781.00
IUUC-Eca-033976	Equus caballus	86.59	0.00e+00	653.00
IUUC-Eeu-034964	Erinaceus europaeus	80.64	0.00e+00	700.00
IUUC-Fca-035662	Felis catus	86.43	3.00e-174	605.00
IUUC-Fal-036996	Ficedula albicollis	70.26	0.00e+00	690.00
IUUC-Gmo-039207	Gadus morhua	74.79	4.00e-47	182.00
IUUC-Gga-040816	Gallus gallus	71.97	0.00e+00	711.00
IUUC-Gma-043292	Glycine max	47.37	2.00e-16	79.70
IUUC-Ggo-044754	Gorilla gorilla	87.07	2.00e-179	622.00
IUUC-Hsa-045776	Homo sapiens	87.07	2.00e-179	622.00
IUUC-Hvu-047745	Hordeum vulgare	50.98	3.00e-14	73.20
IUUC-Itr-048044	Ictidomys tridecemlineatus	86.85	8.00e-178	617.00
IUUC-Lch-050178	Latimeria chalumnae	67.32	8.00e-116	410.00
IUUC-Lpe-051680	Leersia perrieri	42.86	4.00e-14	73.20
IUUC-Loc-052124	Lepisosteus oculatus	56.54	4.00e-99	355.00
IUUC-Laf-054328	Loxodonta africana	85.94	9.00e-175	607.00
IUUC-Mcc-054739	Macaca mulatta	87.07	1.00e-178	619.00
IUUC-Meu-056359	Macropus eugenii	73.97	2.00e-133	469.00
IUUC-Mtr-058167	Medicago truncatula	47.37	2.00e-15	77.00
IUUC-Mga-059838	Meleagris gallopavo	72.46	0.00e+00	717.00
IUUC-Mmr-060608	Microcebus murinus	86.00	3.00e-173	602.00
IUUC-Mdo-061961	Monodelphis domestica	74.71	1.00e-133	470.00
IUUC-Mac-064639	Musa acuminata	42.22	6.00e-15	75.10
IUUC-Mpu-066539	Mustela putorius furo	76.42	1.00e-135	476.00
IUUC-Mlu-066930	Myotis lucifugus	86.17	0.00e+00	638.00
IUUC-Nle-069311	Nomascus leucogenys	87.30	2.00e-179	622.00
IUUC-Opr-071124	Ochotona princeps	90.22	1.00e-78	286.00
IUUC-Oan-073036	Ornithorhynchus anatinus	71.43	2.00e-140	493.00
IUUC-Ocu-073795	Oryctolagus cuniculus	85.49	2.00e-163	569.00
IUUC-Oba-075403	Oryza barthii	42.86	4.00e-14	72.80
IUUC-Obr-076503	Oryza brachyantha	42.86	5.00e-14	72.40
IUUC-Ogl-077574	Oryza glaberrima	42.86	4.00e-14	72.80
IUUC-Ogu-077986	Oryza glumaepatula	42.86	4.00e-14	72.80
IUUC-Oin-079091	Oryza indica	42.86	4.00e-14	73.20
IUUC-Olo-080996	Oryza longistaminata	37.63	9.00e-14	71.20
IUUC-Ome-081627	Oryza meridionalis	42.86	4.00e-14	73.20
IUUC-Oni-082260	Oryza nivara	42.86	4.00e-14	72.80
IUUC-Opu-083578	Oryza punctata	42.86	4.00e-14	73.20
IUUC-Oru-084794	Oryza rufipogon	42.86	4.00e-14	72.80
IUUC-Osa-085348	Oryza sativa	42.86	4.00e-14	72.80
IUUC-Olu-087781	Ostreococcus lucimarinus	40.30	5.00e-13	67.00
IUUC-Oga-088022	Otolemur garnettii	87.47	0.00e+00	640.00
IUUC-Oar-089348	Ovis aries	86.46	3.00e-178	618.00
IUUC-Ptr-090604	Pan troglodytes	87.07	6.00e-179	620.00
IUUC-Pan-092322	Papio anubis	87.07	1.00e-178	619.00
IUUC-Psi-093936	Pelodiscus sinensis	68.79	0.00e+00	669.00
IUUC-Ppa-095197	Physcomitrella patens	46.58	2.00e-16	81.30
IUUC-Pab-098671	Pongo abelii	87.53	8.00e-180	623.00
IUUC-Pop-099808	Populus trichocarpa	47.30	4.00e-16	79.00
IUUC-Pca-100263	Procavia capensis	86.99	0.00e+00	825.00
IUUC-Ppe-101202	Prunus persica	43.59	2.00e-15	77.40
IUUC-Pva-102709	Pteropus vampyrus	85.03	8.00e-163	567.00
IUUC-Ptt-103976	Puccinia triticina	43.75	1.00e-10	59.70
IUUC-Rno-105759	Rattus norvegicus	94.05	2.00e-176	612.00
IUUC-Sha-106792	Sarcophilus harrisii	74.29	3.00e-124	439.00
IUUC-Smo-109572	Selaginella moellendorffii	45.16	9.00e-16	77.00
IUUC-Sit-109852	Setaria italica	42.86	4.00e-14	72.80
IUUC-Sly-111405	Solanum lycopersicum	45.00	2.00e-16	79.70
IUUC-Stu-112609	Solanum tuberosum	46.25	1.00e-16	80.50
IUUC-Sar-113271	Sorex araneus	78.91	3.00e-153	535.00
IUUC-Sbi-114435	Sorghum bicolor	42.86	4.00e-14	72.80
IUUC-Ssc-115738	Sus scrofa	86.20	2.00e-178	619.00
IUUC-Tgu-117205	Taeniopygia guttata	71.08	0.00e+00	702.00
IUUC-Tru-118123	Takifugu rubripes	86.67	2.00e-54	207.00
IUUC-Tsy-119421	Tarsius syrichta	87.56	0.00e+00	656.00
IUUC-Tca-121367	Theobroma cacao	47.37	2.00e-16	80.10
IUUC-Tae-123264	Triticum aestivum	36.27	7.00e-16	78.60
IUUC-Tur-126084	Triticum urartu	48.89	2.00e-13	72.40
IUUC-Tbe-127543	Tupaia belangeri	84.24	0.00e+00	864.00
IUUC-Vpa-130058	Vicugna pacos	86.65	2.00e-175	608.00
IUUC-Vvi-131093	Vitis vinifera	46.05	4.00e-16	79.30
IUUC-Xtr-132663	Xenopus tropicalis	60.72	5.00e-99	355.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence