iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000008109.2	ENSLACT00000025112.1	ENSLACP00000023194.1
ENSLACG00000008109.2	ENSLACT00000009258.1	ENSLACP00000009188.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-79	266.8	198	846

Active Site

Position(s)	Description	Evidence
207	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
782	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp............kepkgellkslqklfeelwkskkkavsprellk 75
           +Gl+NlgNtC++N+v+Q L+++  lr+ll+e   ++ +++ + p             e+ g+l++++ ++++e +++kk+ v+p+el++
   Q: 198  KGLSNLGNTCFFNAVMQNLLQTYILRDLLKEvrTTETTIKIT-PpdsnlleesvvnLEQPGPLTSTMCQFLKETQETKKGTVTPKELFS 285
           5******************************85222233333.246666666666688888**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcle 158
           +++k+a++f+gy+qqD++E+l++lld++++e  k+  k   ++++++ ++l++e      +e++k    ++++++lF+g+l+s+++c+e
   Q: 286  QVCKKAVRFKGYQQQDSHELLRYLLDGMRTEEIKRVVKGMLKSCNNSPEKLEEEelekrlKEYEKRGAVPNFVDQLFGGELTSTVRCEE 374
           *****************************99988788888888888888888876666667777777888******************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.............................................................. 185
           c++v+  +e+fldlslpv +++  kk+                                                              
   Q: 375  CKTVTLVTEKFLDLSLPVLDEQVDKKKttarsrkvssegeeedygsyvkdrnevssgtskhqqkkakkqakkqsknqrkqqklqekvlp 463
           **********************998889************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 464  lgtftatqqqsegkddlleeasslrdqcekngteeeeeeeslnltqsenpqihqetsvsnqevsengetssgtsremeneetssgtsre 552
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 553  veneemssgtsamlasttcilnqfnslsieddggeeekevvngltklnlddavldlelegsleedkdekeecilakeyqvvsedpetaf 641
           ***************************************************************************************** PP
   S: 186  ..............slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeq 243
                         s++ +L +ft++e+l+g nk+ c+ c++kq                  a+k++ ++  P+vL+lhLkRf  ++++
   Q: 642  splsnretvntqecSIETSLFQFTQPESLNGINKLLCNVCTQKQHrgskasgngekkkaytnAQKQMLISLAPPVLTLHLKRF--QQAG 728
           *****************************************999999999999999999999*********************..9999 PP
   S: 244  ksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgk 305
            + +k+nk+v+fp++Ld++pfct +++++ e    + Y+L+++v H+G+++sGHY+ayvk                          +g+
   Q: 729  FNLRKVNKYVQFPQQLDVAPFCTVKCKNVGEgdkGVLYNLYGIVEHTGTMRSGHYTAYVKVrapsshlsdhiltgtipqatkaeaPRGS 817
           ************************999887777799*************************9999999999999999988887777888 PP
   S: 306  WllfdDskVtevkeeevleetgstaYvlfYkr 337
           W++++D++V++v+e++v++   s+aY+lfY+r
   Q: 818  WFHVSDTHVQPVPETKVVN---SQAYLLFYER 846
           *******************...********98 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKRKGKGKS SQADDDTDTF DQNCRHIRKG LDQNQLKKAL VEVKWNVCQS CKTEKTPAEE 60
TDESPPIWLC LKCGHQGCGR SCEEQHAVKH YETLRSEPHC LVLGLDCWNV WCYICDKDVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGGTTGT TCACGGAAAA GAGAAAGTTC GGCGAGAGGT AGAAACCCCC AAATCAACAA 60
CTTAAATAGC AATTTGTAAC TCGCTGTTCC CTCAGAATAA GCACAAGTGA ACTCCACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102347481

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	35.83	1.00e-27	118.00
IUUC-Aml-001931	Ailuropoda melanoleuca	52.56	0.00e+00	776.00
IUUC-Atr-003015	Amborella trichopoda	29.37	1.00e-34	141.00
IUUC-Apl-004145	Anas platyrhynchos	52.01	0.00e+00	723.00
IUUC-Aca-004314	Anolis carolinensis	52.11	0.00e+00	739.00
IUUC-Aly-006422	Arabidopsis lyrata	30.21	7.00e-29	122.00
IUUC-Ath-006732	Arabidopsis thaliana	32.39	2.00e-33	137.00
IUUC-Ame-011659	Astyanax mexicanus	48.16	4.00e-105	375.00
IUUC-Bta-013362	Bos taurus	52.73	0.00e+00	765.00
IUUC-Bdi-014624	Brachypodium distachyon	28.92	8.00e-28	119.00
IUUC-Bol-015191	Brassica oleracea	29.03	2.00e-32	134.00
IUUC-Bra-016751	Brassica rapa	29.82	1.00e-26	115.00
IUUC-Cja-019177	Callithrix jacchus	53.37	0.00e+00	779.00
IUUC-Cfa-020051	Canis familiaris	52.56	0.00e+00	771.00
IUUC-Cpo-021886	Cavia porcellus	54.71	6.00e-129	454.00
IUUC-Csa-024103	Chlorocebus sabaeus	53.72	0.00e+00	788.00
IUUC-Cho-024315	Choloepus hoffmanni	54.93	3.00e-65	243.00
IUUC-Cin-025775	Ciona intestinalis	48.20	1.00e-35	141.00
IUUC-Csv-026075	Ciona savignyi	48.45	2.00e-50	193.00
IUUC-Dre-028388	Danio rerio	49.89	1.00e-112	400.00
IUUC-Dno-029409	Dasypus novemcinctus	52.09	0.00e+00	773.00
IUUC-Dor-030443	Dipodomys ordii	53.68	2.00e-101	363.00
IUUC-Ete-032807	Echinops telfairi	53.33	1.00e-115	410.00
IUUC-Eca-033479	Equus caballus	52.68	0.00e+00	781.00
IUUC-Fca-036320	Felis catus	53.08	0.00e+00	786.00
IUUC-Gmo-039480	Gadus morhua	51.07	2.00e-109	390.00
IUUC-Gga-040527	Gallus gallus	51.39	0.00e+00	714.00
IUUC-Gac-042343	Gasterosteus aculeatus	49.55	8.00e-110	391.00
IUUC-Gma-044402	Glycine max	31.44	3.00e-37	150.00
IUUC-Ggo-045598	Gorilla gorilla	53.84	0.00e+00	783.00
IUUC-Hsa-046598	Homo sapiens	53.84	0.00e+00	782.00
IUUC-Hvu-047146	Hordeum vulgare	35.78	2.00e-26	114.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	52.78	0.00e+00	785.00
IUUC-Lpe-050703	Leersia perrieri	29.91	1.00e-28	122.00
IUUC-Loc-051814	Lepisosteus oculatus	58.87	3.00e-128	452.00
IUUC-Laf-053732	Loxodonta africana	52.38	0.00e+00	783.00
IUUC-Mcc-054661	Macaca mulatta	53.84	0.00e+00	787.00
IUUC-Meu-055967	Macropus eugenii	56.00	1.00e-116	414.00
IUUC-Mtr-057945	Medicago truncatula	33.04	9.00e-35	142.00
IUUC-Mga-059551	Meleagris gallopavo	51.67	0.00e+00	727.00
IUUC-Mvi-060391	Microbotryum violaceum	32.79	4.00e-15	77.00
IUUC-Mmr-061747	Microcebus murinus	53.29	0.00e+00	770.00
IUUC-Mdo-062220	Monodelphis domestica	58.75	1.00e-134	473.00
IUUC-Mmu-063582	Mus musculus	51.99	0.00e+00	743.00
IUUC-Mac-064941	Musa acuminata	29.56	1.00e-35	144.00
IUUC-Mpu-066339	Mustela putorius furo	52.67	0.00e+00	774.00
IUUC-Mlu-067511	Myotis lucifugus	52.43	0.00e+00	744.00
IUUC-Nle-069252	Nomascus leucogenys	54.07	0.00e+00	788.00
IUUC-Opr-070969	Ochotona princeps	51.98	0.00e+00	731.00
IUUC-Ont-071786	Oreochromis niloticus	50.23	2.00e-105	377.00
IUUC-Ocu-074704	Oryctolagus cuniculus	53.56	0.00e+00	764.00
IUUC-Oba-075094	Oryza barthii	29.25	5.00e-28	120.00
IUUC-Obr-076743	Oryza brachyantha	31.12	4.00e-29	124.00
IUUC-Ogl-077739	Oryza glaberrima	29.25	4.00e-28	120.00
IUUC-Ogu-078851	Oryza glumaepatula	29.25	4.00e-28	120.00
IUUC-Oin-079402	Oryza indica	29.25	4.00e-28	120.00
IUUC-Olo-080431	Oryza longistaminata	29.25	4.00e-28	120.00
IUUC-Ome-081580	Oryza meridionalis	29.25	6.00e-28	119.00
IUUC-Oni-082644	Oryza nivara	29.25	4.00e-28	120.00
IUUC-Opu-083452	Oryza punctata	29.00	7.00e-28	119.00
IUUC-Oru-084546	Oryza rufipogon	29.25	5.00e-28	120.00
IUUC-Osa-085858	Oryza sativa	29.25	4.00e-28	120.00
IUUC-Ola-086795	Oryzias latipes	49.66	2.00e-108	387.00
IUUC-Oga-088713	Otolemur garnettii	52.15	0.00e+00	778.00
IUUC-Oar-089887	Ovis aries	52.96	0.00e+00	764.00
IUUC-Ptr-091670	Pan troglodytes	53.66	0.00e+00	779.00
IUUC-Pan-092293	Papio anubis	53.84	0.00e+00	787.00
IUUC-Psi-093101	Pelodiscus sinensis	58.56	4.00e-127	448.00
IUUC-Ppa-095622	Physcomitrella patens	30.66	9.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	45.18	0.00e+00	651.00
IUUC-Pab-098773	Pongo abelii	53.66	4.00e-168	584.00
IUUC-Pop-099588	Populus trichocarpa	30.03	2.00e-35	144.00
IUUC-Pca-101069	Procavia capensis	67.12	3.00e-88	319.00
IUUC-Ppe-101794	Prunus persica	31.51	8.00e-37	149.00
IUUC-Pva-103092	Pteropus vampyrus	46.08	4.00e-91	329.00
IUUC-Rno-105237	Rattus norvegicus	52.38	0.00e+00	735.00
IUUC-Sha-106889	Sarcophilus harrisii	51.84	0.00e+00	754.00
IUUC-Sit-110283	Setaria italica	30.33	4.00e-27	117.00
IUUC-Sly-111491	Solanum lycopersicum	28.50	7.00e-37	149.00
IUUC-Stu-112820	Solanum tuberosum	29.57	5.00e-40	159.00
IUUC-Sar-113530	Sorex araneus	58.23	2.00e-130	459.00
IUUC-Sbi-113785	Sorghum bicolor	34.58	9.00e-23	102.00
IUUC-Ssc-116091	Sus scrofa	52.97	0.00e+00	779.00
IUUC-Tgu-117478	Taeniopygia guttata	55.45	1.00e-118	421.00
IUUC-Tru-118640	Takifugu rubripes	51.68	4.00e-111	395.00
IUUC-Tsy-119042	Tarsius syrichta	44.01	2.00e-130	459.00
IUUC-Tni-120015	Tetraodon nigroviridis	49.76	8.00e-105	374.00
IUUC-Tca-121701	Theobroma cacao	29.59	2.00e-39	157.00
IUUC-Tae-125351	Triticum aestivum	35.78	2.00e-26	114.00
IUUC-Tur-126788	Triticum urartu	28.40	8.00e-27	115.00
IUUC-Tbe-127309	Tupaia belangeri	53.67	3.00e-84	306.00
IUUC-Ttr-128271	Tursiops truncatus	52.77	0.00e+00	758.00
IUUC-Vpa-130674	Vicugna pacos	53.03	0.00e+00	695.00
IUUC-Xtr-131869	Xenopus tropicalis	53.06	7.00e-120	424.00
IUUC-Xma-134195	Xiphophorus maculatus	50.33	3.00e-118	419.00
IUUC-Zma-135157	Zea mays	29.39	5.00e-25	110.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence