iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054950

Ensembl Protein ID

ENSMMUP00000023298.2

UniProt Accession

F6U2Y2; F6U2Y2_MACMU

Genbank Protein ID

ENSMMUP00000023298

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03037213

Gene Name

ARHGEF37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000017714.3	ENSMMUT00000024897.3	ENSMMUP00000023298.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-10	40.8	605	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++ y++ a ++ e +l++G  v+++  ++++ + +W     e +g+rG +P+ F ++++
   Q: 605  NQVIAVYPFVARSSHEVSLQAGQPVTILeaQDKKGNPEWSLV--EVNGQRGYVPSGFLARAQ 664
           789*************************9889999****977..9************99986 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAKHGADELS CRSGSLDGEG RASEDRSLLR QRLAVQELID TEVSYLHMLQ LCASDIRSRL 60
QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKKEEQV RLVGNLFLEF QEELEQVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACGCAGG CAGCAGCGTG GGCATAGCTG CGCCCGCCAG CGCCCTCGGT GGGCAGAGCC 60
GCGCGAAGCG GCGCGGTTGC GGGTAGCTGG GCGACGCACC CCTCCCGCCC CAGCTGCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF03114--BAR
PF00621--RhoGEF
PF07653--SH3_2
PF14604--SH3_9

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

mcc:710950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	40.31	3.00e-130	459.00
IUUC-Bta-012848	Bos taurus	85.48	0.00e+00	1110.00
IUUC-Cfa-021281	Canis familiaris	84.30	0.00e+00	1104.00
IUUC-Csa-023043	Chlorocebus sabaeus	98.67	0.00e+00	1306.00
IUUC-Dre-028496	Danio rerio	40.19	6.00e-128	451.00
IUUC-Ete-032921	Echinops telfairi	62.07	1.00e-71	262.00
IUUC-Ggo-044900	Gorilla gorilla	96.00	0.00e+00	1266.00
IUUC-Hsa-045684	Homo sapiens	95.26	0.00e+00	1286.00
IUUC-Lch-050096	Latimeria chalumnae	47.02	8.00e-172	597.00
IUUC-Loc-051937	Lepisosteus oculatus	42.29	1.00e-137	483.00
IUUC-Meu-056383	Macropus eugenii	69.01	9.00e-172	597.00
IUUC-Mdo-062021	Monodelphis domestica	68.21	0.00e+00	877.00
IUUC-Mmu-064186	Mus musculus	79.14	0.00e+00	1036.00
IUUC-Ptr-090508	Pan troglodytes	95.70	0.00e+00	1262.00
IUUC-Pan-092517	Papio anubis	98.52	0.00e+00	1280.00
IUUC-Pfo-096703	Poecilia formosa	39.23	8.00e-126	444.00
IUUC-Pab-098542	Pongo abelii	95.70	0.00e+00	1256.00
IUUC-Rno-105455	Rattus norvegicus	80.62	0.00e+00	1071.00
IUUC-Sha-106562	Sarcophilus harrisii	69.66	0.00e+00	884.00
IUUC-Ttr-128242	Tursiops truncatus	82.07	0.00e+00	1069.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence