iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087998

Ensembl Protein ID

ENSOGAP00000004248.2

UniProt Accession

H0WQL5; H0WQL5_OTOGA

Genbank Protein ID

ENSOGAP00000004248

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03111757

Gene Name

WDR48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004748.2	ENSOGAT00000004753.2	ENSOGAP00000004248.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.00e-33	111.7	210	247
UBD/Beta-Prp	1.70e-47	162.0	33	296
ULD/UDP/UFD/RAWUL	1.00e-23	83.6	570	675
ULD/UBL/SUMO	2.40e-63	210.8	561	668

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHtd v +l +  d t  +sGs Dgti++W+l +++++
   Q: 210  GHTDNVKALLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 247
           8********88*888*****************999997 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           + +++++  p  + l+t++rd+ i++w+v + k    ++s++ h++ v+++ +  +gk+l+++s+D t+kvw+  +g c++tl+ h+d+
   Q: 33   NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY 121
           55677888888999*****************999999**************************************************** PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           v +l++ ++++ ++s++ dr i +wd++t + l +         lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t   l +l+g
   Q: 122  VKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 210
           *********************************999*****999**********************************99999999999 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
            htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ +  ++++sg+ D+ i++ dlr+ d+   +  ++
   Q: 211  -HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEK 296
           .***********************************************************************999988776666666 PP

ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy.....................evdllcedevLedn 63
            L+p++s++ak+   lkk++l++s++l+V++++++++ek+++        s                        +++llc+d+vL++n
   Q: 570  YLQPHASSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINldnesqttS--SsnnekpgeqekeediavlaeeKIELLCQDQVLDPN 653
           69**********...*************************99988766653..045799999999************************ PP
   S: 64   etLeeikyifiwkkegpLvLqYr 86
           ++L+++ ++fiwk++g+L+L+Yr
   Q: 654  MDLRTV-KHFIWKSGGDLTLHYR 675
           ******.***************9 PP

ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfv.fngqkireqetpeelevededkiellcq... 81
           ++kf+k+p++l++++++G+++l+k++lsa    q++k+me+vY+k+inld++s++++ +n++k++eqe++e+++v++e+kiellcq   
   Q: 561  MPKFNKIPFYLQPHASSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINLDNESQTTSsSNNEKPGEQEKEEDIAVLAEEKIELLCQdqv 649
           8********************************************************9****************************777 PP
   S: 82   ...............ksGG 85
                          ksGG
   Q: 650  ldpnmdlrtvkhfiwKSGG 668
           7777777777777777776 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

IYSHEEQRSP TVEKRVLKVS YVIRDEVEKY NRNGVNALQL DPALNRLFTA GRDSIIRIWS 60
VNQHKQDPYI ASMEHHTDWV NDIVLCCNGK TLISASSDTT VKVWNAHKGF CMSTLRTHKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATATTCTC ATGAGGAACA GAGGTCACCA ACAGTGGAGA AAAGAGTCCT GAAGGAGGAG 60
TTTATAGTGT GTTATAGGAA TTCAAAACCT CATTTCACTT GAAAAATCAG GGAAGGCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0000724--P:double-strand break repair via homologous recombination
GO:0048568--P:embryonic organ development
GO:0048872--P:homeostasis of number of cells
GO:0035264--P:multicellular organism growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0016579--P:protein deubiquitination
GO:1902525--P:regulation of protein monoubiquitination
GO:0072520--P:seminiferous tubule development
GO:0007338--P:single fertilization
GO:0048705--P:skeletal system morphogenesis
GO:0043588--P:skin development
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001160	Aegilops tauschii	40.36	6.00e-97	348.00
IUUC-Aml-001533	Ailuropoda melanoleuca	98.07	0.00e+00	1246.00
IUUC-Atr-003009	Amborella trichopoda	33.86	5.00e-110	392.00
IUUC-Apl-003709	Anas platyrhynchos	98.54	0.00e+00	667.00
IUUC-Aca-004875	Anolis carolinensis	96.88	0.00e+00	1273.00
IUUC-Aly-005464	Arabidopsis lyrata	40.65	1.00e-92	334.00
IUUC-Ath-006969	Arabidopsis thaliana	39.92	8.00e-89	321.00
IUUC-Acl-008203	Aspergillus clavatus	35.40	1.00e-47	185.00
IUUC-Afl-008571	Aspergillus flavus	35.33	1.00e-46	181.00
IUUC-Afu-009072	Aspergillus fumigatus	35.03	3.00e-45	177.00
IUUC-Ani-009413	Aspergillus nidulans	36.13	3.00e-48	187.00
IUUC-Ang-009571	Aspergillus niger	35.02	4.00e-45	176.00
IUUC-Aor-010064	Aspergillus oryzae	35.33	6.00e-47	182.00
IUUC-Ate-010463	Aspergillus terreus	34.73	2.00e-46	181.00
IUUC-Ame-010875	Astyanax mexicanus	94.73	0.00e+00	1098.00
IUUC-Bgr-012288	Blumeria graminis	34.12	3.00e-41	164.00
IUUC-Bta-013379	Bos taurus	98.37	0.00e+00	1248.00
IUUC-Bci-013859	Botrytis cinerea	32.37	6.00e-41	162.00
IUUC-Bdi-014645	Brachypodium distachyon	35.36	1.00e-111	397.00
IUUC-Bol-015551	Brassica oleracea	35.07	6.00e-105	375.00
IUUC-Bra-017237	Brassica rapa	34.29	2.00e-101	363.00
IUUC-Cel-018656	Caenorhabditis elegans	44.59	2.00e-155	542.00
IUUC-Cja-018804	Callithrix jacchus	98.07	0.00e+00	1244.00
IUUC-Cfa-020076	Canis familiaris	98.51	0.00e+00	1250.00
IUUC-Cpo-021721	Cavia porcellus	98.04	0.00e+00	1220.00
IUUC-Cre-022779	Chlamydomonas reinhardtii	30.66	3.00e-40	160.00
IUUC-Csa-023188	Chlorocebus sabaeus	98.51	0.00e+00	1250.00
IUUC-Cho-024932	Choloepus hoffmanni	97.33	0.00e+00	1254.00
IUUC-Cin-025591	Ciona intestinalis	56.03	0.00e+00	720.00
IUUC-Cgl-026540	Colletotrichum gloeosporioides	27.24	4.00e-20	94.00
IUUC-Cne-026819	Cryptococcus neoformans	35.53	2.00e-34	142.00
IUUC-Cme-027188	Cyanidioschyzon merolae	31.98	3.00e-72	266.00
IUUC-Dre-027926	Danio rerio	91.68	0.00e+00	1251.00
IUUC-Dno-029960	Dasypus novemcinctus	97.62	0.00e+00	1239.00
IUUC-Dor-030933	Dipodomys ordii	95.26	0.00e+00	714.00
IUUC-Dse-031532	Dothistroma septosporum	35.40	7.00e-46	179.00
IUUC-Dme-032168	Drosophila melanogaster	56.47	0.00e+00	681.00
IUUC-Ete-033107	Echinops telfairi	96.97	0.00e+00	1199.00
IUUC-Eca-034028	Equus caballus	98.37	0.00e+00	1249.00
IUUC-Eeu-034894	Erinaceus europaeus	96.61	0.00e+00	848.00
IUUC-Fca-035619	Felis catus	97.75	0.00e+00	926.00
IUUC-Fal-036869	Ficedula albicollis	98.19	0.00e+00	1267.00
IUUC-Fox-037907	Fusarium oxysporum	32.76	6.00e-41	162.00
IUUC-Fso-038101	Fusarium solani	33.05	2.00e-40	160.00
IUUC-Gmo-038627	Gadus morhua	93.91	0.00e+00	1268.00
IUUC-Ggr-039995	Gaeumannomyces graminis	30.73	2.00e-41	164.00
IUUC-Gga-040555	Gallus gallus	97.18	0.00e+00	1273.00
IUUC-Gac-042497	Gasterosteus aculeatus	93.61	0.00e+00	1239.00
IUUC-Gma-043089	Glycine max	34.55	7.00e-110	391.00
IUUC-Ggo-045561	Gorilla gorilla	98.51	0.00e+00	1250.00
IUUC-Hsa-045710	Homo sapiens	98.51	0.00e+00	1250.00
IUUC-Hvu-047730	Hordeum vulgare	35.65	9.00e-85	307.00
IUUC-Itr-049030	Ictidomys tridecemlineatus	99.79	0.00e+00	903.00
IUUC-Kpa-049237	Komagataella pastoris	30.67	5.00e-30	126.00
IUUC-Lch-049507	Latimeria chalumnae	95.84	0.00e+00	1241.00
IUUC-Lpe-051608	Leersia perrieri	35.12	3.00e-109	389.00
IUUC-Loc-052373	Lepisosteus oculatus	92.44	0.00e+00	1225.00
IUUC-Lma-053025	Leptosphaeria maculans	35.84	9.00e-49	189.00
IUUC-Laf-053706	Loxodonta africana	98.94	0.00e+00	1238.00
IUUC-Mcc-055046	Macaca mulatta	98.51	0.00e+00	1250.00
IUUC-Meu-056840	Macropus eugenii	80.72	3.00e-150	525.00
IUUC-Mor-057284	Magnaporthe oryzae	32.93	8.00e-43	169.00
IUUC-Mpo-057418	Magnaporthe poae	30.45	3.00e-40	160.00
IUUC-Mtr-058571	Medicago truncatula	34.82	5.00e-109	388.00
IUUC-Mla-059101	Melampsora laricipopulina	45.10	1.00e-45	179.00
IUUC-Mga-059297	Meleagris gallopavo	97.18	0.00e+00	1273.00
IUUC-Mvi-060419	Microbotryum violaceum	37.01	2.00e-38	155.00
IUUC-Mmr-061196	Microcebus murinus	92.93	0.00e+00	1149.00
IUUC-Mdo-062762	Monodelphis domestica	93.57	0.00e+00	1258.00
IUUC-Mmu-063915	Mus musculus	97.33	0.00e+00	1268.00
IUUC-Mac-065434	Musa acuminata	34.23	2.00e-105	377.00
IUUC-Mpu-065999	Mustela putorius furo	96.94	0.00e+00	818.00
IUUC-Mlu-068226	Myotis lucifugus	98.22	0.00e+00	1245.00
IUUC-Nfi-068416	Neosartorya fischeri	29.75	3.00e-56	213.00
IUUC-Ncr-068825	Neurospora crassa	31.30	4.00e-39	157.00
IUUC-Nle-069416	Nomascus leucogenys	98.51	0.00e+00	1250.00
IUUC-Opr-070515	Ochotona princeps	94.06	0.00e+00	1175.00
IUUC-Ont-072052	Oreochromis niloticus	91.29	0.00e+00	1176.00
IUUC-Oan-073636	Ornithorhynchus anatinus	94.86	0.00e+00	1256.00
IUUC-Ocu-074799	Oryctolagus cuniculus	98.37	0.00e+00	1248.00
IUUC-Oba-075146	Oryza barthii	35.43	8.00e-110	391.00
IUUC-Obr-076699	Oryza brachyantha	35.14	1.00e-110	393.00
IUUC-Ogl-077883	Oryza glaberrima	33.67	6.00e-67	248.00
IUUC-Ogu-078114	Oryza glumaepatula	35.44	3.00e-109	389.00
IUUC-Oin-079575	Oryza indica	35.45	1.00e-112	400.00
IUUC-Olo-080531	Oryza longistaminata	32.99	7.00e-99	355.00
IUUC-Ome-081368	Oryza meridionalis	41.00	1.00e-97	350.00
IUUC-Oni-082457	Oryza nivara	35.43	1.00e-109	390.00
IUUC-Opu-084050	Oryza punctata	35.29	7.00e-109	388.00
IUUC-Oru-084330	Oryza rufipogon	35.43	8.00e-110	391.00
IUUC-Osa-085408	Oryza sativa	35.45	1.00e-112	400.00
IUUC-Ola-087546	Oryzias latipes	93.24	0.00e+00	1239.00
IUUC-Olu-087710	Ostreococcus lucimarinus	30.99	4.00e-80	292.00
IUUC-Oar-090303	Ovis aries	98.37	0.00e+00	1248.00
IUUC-Ptr-090588	Pan troglodytes	98.51	0.00e+00	1250.00
IUUC-Pan-092722	Papio anubis	98.51	0.00e+00	1250.00
IUUC-Psi-093911	Pelodiscus sinensis	96.31	0.00e+00	1269.00
IUUC-Pma-094580	Petromyzon marinus	86.60	0.00e+00	1162.00
IUUC-Pno-095085	Phaeosphaeria nodorum	35.03	2.00e-43	171.00
IUUC-Ppa-095594	Physcomitrella patens	35.76	3.00e-113	402.00
IUUC-Pfo-096994	Poecilia formosa	93.36	0.00e+00	1235.00
IUUC-Pab-097586	Pongo abelii	98.37	0.00e+00	1249.00
IUUC-Pop-099740	Populus trichocarpa	34.87	8.00e-103	367.00
IUUC-Pca-100458	Procavia capensis	98.56	1.00e-106	380.00
IUUC-Ppe-102060	Prunus persica	34.47	7.00e-108	384.00
IUUC-Pva-102698	Pteropus vampyrus	93.61	0.00e+00	1231.00
IUUC-Pgr-103649	Puccinia graminis	34.42	3.00e-48	187.00
IUUC-Ptt-103910	Puccinia triticina	43.90	2.00e-53	204.00
IUUC-Pte-104181	Pyrenophora teres	36.45	1.00e-48	188.00
IUUC-Pyt-104439	Pyrenophora triticirepentis	36.14	3.00e-48	187.00
IUUC-Rno-104978	Rattus norvegicus	98.79	0.00e+00	1264.00
IUUC-Sha-107079	Sarcophilus harrisii	97.48	0.00e+00	1202.00
IUUC-Sja-107716	Schizosaccharomyces japonicus	30.68	3.00e-59	223.00
IUUC-Spo-108325	Schizosaccharomyces pombe	30.80	8.00e-52	199.00
IUUC-Ssl-108542	Sclerotinia sclerotiorum	28.81	6.00e-45	176.00
IUUC-Smo-109427	Selaginella moellendorffii	34.77	5.00e-110	391.00
IUUC-Sit-110755	Setaria italica	36.86	7.00e-115	408.00
IUUC-Sly-111099	Solanum lycopersicum	35.16	5.00e-98	352.00
IUUC-Sar-113408	Sorex araneus	96.91	0.00e+00	742.00
IUUC-Sbi-113789	Sorghum bicolor	35.45	3.00e-111	395.00
IUUC-Sre-114998	Sporisorium reilianum	39.93	4.00e-52	200.00
IUUC-Ssc-115434	Sus scrofa	98.51	0.00e+00	1250.00
IUUC-Tgu-116517	Taeniopygia guttata	97.18	0.00e+00	1276.00
IUUC-Tru-118174	Takifugu rubripes	93.79	0.00e+00	1242.00
IUUC-Tsy-118935	Tarsius syrichta	98.22	0.00e+00	1276.00
IUUC-Tni-119744	Tetraodon nigroviridis	94.21	0.00e+00	1210.00
IUUC-Tca-121360	Theobroma cacao	34.47	1.00e-111	397.00
IUUC-Tre-122198	Trichoderma reesei	32.56	1.00e-42	169.00
IUUC-Tvi-122389	Trichoderma virens	32.56	1.00e-42	168.00
IUUC-Tae-125576	Triticum aestivum	35.56	1.00e-112	400.00
IUUC-Tur-126699	Triticum urartu	35.33	5.00e-110	392.00
IUUC-Tme-126932	Tuber melanosporum	31.96	9.00e-55	209.00
IUUC-Tbe-127267	Tupaia belangeri	85.21	0.00e+00	736.00
IUUC-Ttr-129153	Tursiops truncatus	97.92	0.00e+00	1279.00
IUUC-Uma-129604	Ustilago maydis	41.26	3.00e-50	194.00
IUUC-Vda-129925	Verticillium dahliae	34.81	2.00e-45	177.00
IUUC-Vpa-130553	Vicugna pacos	96.94	0.00e+00	951.00
IUUC-Vvi-130995	Vitis vinifera	34.38	2.00e-106	380.00
IUUC-Xtr-132346	Xenopus tropicalis	93.03	0.00e+00	1212.00
IUUC-Xma-134266	Xiphophorus maculatus	93.18	0.00e+00	672.00
IUUC-Yli-134451	Yarrowia lipolytica	27.98	1.00e-38	155.00
IUUC-Zma-135647	Zea mays	35.71	7.00e-113	401.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence