iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008805

Ensembl Protein ID

CADAFUAP00003290

UniProt Accession

Q4WH81; Q4WH81_ASPFU

Genbank Protein ID

EAL87724.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAHF01000008

Gene Name

AFUA_2G06330

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00003290	CADAFUAT00003290	CADAFUAP00003290

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-54	183.3	216	693
UBD/Alpha-Helix/UBA	3.30e-23	80.1	565	603

Active Site

Position(s)	Description	Evidence
225	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
648	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkkavsprell 74
           tGl+NlgN+CY+ Sv+QcL++ pe+++ + + ++++ + +  ++p +++ ++++kl   +                      ++k  sp +++
   Q: 216  TGLTNLGNSCYLSSVVQCLFSSPEFQRRYYH-NSKEPPLS--QQPAEDFETQMRKLADGIlsgryskpnadviaspdspEVPHQKGLSPAMFK 305
           7************************999999.44444444..5677788888888888884444444444444433332255666******** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           + +++ +eefs+++qqDa Efl +l++ ++++                            ++ + ++i d+F++ ++++++cl+c+ v  r +
   Q: 306  HLIGRGHEEFSTMRQQDAFEFLLHLFKLIQRTQ--------------------------SPEGGGNPI-DNFRFAVEQRLQCLSCKGVRYRID 371
           *******************************98..........................445555555.89********************** PP
   S: 168  pfldlslpvpgkeetkke.............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           +   +s+pvp +++  ++             +l++cL+ ft++e +e    ++c++c ++   +k+ +++++P+ L+l+  Rf  +  +++++
   Q: 372  EQDNVSIPVPVRRQLGTNstdpsadsefesvTLSECLDVFTANEIVE----LSCPSCGNSNGFSKRSSFRTMPQELVLNARRF--EVVNWVPR 458
           **********777665557888899999999***************9....9*******************************..5577**** PP
   S: 248  kinkkvefple.Ldlspfctspeekqke................................................................. 274
           k++  v++ +e Ld sp++ s +e+ ++                                                                 
   Q: 459  KLDIPVNVSDEpLDFSPYVGSMKEEGEKllpeddpsvsgfspdqnilnqllamgfpkircekalhatgnsdteaamnwlfshmddpdidiplv 551
           *********************554444456666666666666666666666666666666667777777777777777777777777777777 PP
   S: 275  ............................................................................kkkYeLiavvvHsG.sl 290
                                                                                       + +Y+L a+v+H+G s+
   Q: 552  vskvtgpanmalqdpskvsqliemgidedraqralaatggdvdraldwvfshpderpeyksgdcdsgsrlpgfnetPAIYQLRAIVCHKGtSV 644
           7777777777777777778888888888888888888888888888888888888888999999999999999999***************** PP
   S: 291  ssGHYvayvkn.....ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           + GHYva+v++     ++ +W+ f+D+kV  v+  +  +   + aY++f+ r
   Q: 645  HAGHYVAFVRKtlpgqDNPSWVMFNDEKVVGVDDIQDMK---KFAYLYFFSR 693
           ***********877644445************7544444...79*****987 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d +k+ ql+eMG+d+++a++aL+a+++++++A+++++++
   Q: 565  DPSKVSQLIEMGIDEDRAQRALAATGGDVDRALDWVFSH 603
           789**********************************97 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MLHYKRFCHP LALNIKRSRK KIQRGEPPQK ISKLAIAAET DEDRYDTAIR VICYECRLDD 60
IDASSGSLAV VVDGVMKAMT FSRKEEIKAW EQEFVPCEHT LCLVQQTPKQ IDQFGGLGGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTACATT ACAAGCGCTT TTGCCATCCT TTAGCACTGA ACATCAAGAG GTCGCGAAAG 60
AAGATACAGG TACGTGGACG CCATATCCAC TCGCAATGCG TACAATATTC GGTGTCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afm:AFUA_2G06330

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	33.22	1.00e-84	306.00
IUUC-Aml-002104	Ailuropoda melanoleuca	33.82	5.00e-111	393.00
IUUC-Atr-002580	Amborella trichopoda	32.60	1.00e-98	352.00
IUUC-Apl-003774	Anas platyrhynchos	34.77	3.00e-118	417.00
IUUC-Aca-005368	Anolis carolinensis	33.88	1.00e-117	415.00
IUUC-Aly-005727	Arabidopsis lyrata	33.64	5.00e-105	373.00
IUUC-Ath-006974	Arabidopsis thaliana	34.07	5.00e-106	377.00
IUUC-Ago-007890	Ashbya gossypii	34.44	2.00e-88	318.00
IUUC-Acl-008057	Aspergillus clavatus	71.06	0.00e+00	1071.00
IUUC-Afl-008547	Aspergillus flavus	66.46	0.00e+00	923.00
IUUC-Ani-009441	Aspergillus nidulans	64.26	0.00e+00	897.00
IUUC-Ang-009720	Aspergillus niger	64.84	0.00e+00	944.00
IUUC-Aor-010111	Aspergillus oryzae	67.26	0.00e+00	1028.00
IUUC-Ate-010531	Aspergillus terreus	60.90	0.00e+00	865.00
IUUC-Ame-011893	Astyanax mexicanus	34.25	5.00e-92	330.00
IUUC-Bgr-012183	Blumeria graminis	49.66	0.00e+00	729.00
IUUC-Bta-013179	Bos taurus	33.78	4.00e-110	390.00
IUUC-Bci-013858	Botrytis cinerea	56.03	0.00e+00	837.00
IUUC-Bdi-014904	Brachypodium distachyon	38.15	8.00e-93	333.00
IUUC-Bol-015296	Brassica oleracea	33.25	5.00e-104	370.00
IUUC-Bra-017619	Brassica rapa	34.16	4.00e-107	380.00
IUUC-Cel-018625	Caenorhabditis elegans	32.44	1.00e-71	263.00
IUUC-Cja-019063	Callithrix jacchus	33.45	2.00e-107	382.00
IUUC-Cfa-020976	Canis familiaris	34.64	3.00e-114	404.00
IUUC-Cpo-022265	Cavia porcellus	34.47	6.00e-114	403.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	31.11	5.00e-58	217.00
IUUC-Csa-024177	Chlorocebus sabaeus	34.94	4.00e-101	360.00
IUUC-Cho-024702	Choloepus hoffmanni	34.49	2.00e-81	295.00
IUUC-Cin-025411	Ciona intestinalis	30.62	1.00e-87	316.00
IUUC-Csv-026347	Ciona savignyi	31.95	1.00e-83	302.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	53.21	0.00e+00	730.00
IUUC-Cne-026831	Cryptococcus neoformans	40.67	2.00e-149	521.00
IUUC-Cme-027335	Cyanidioschyzon merolae	34.30	1.00e-39	156.00
IUUC-Dre-027982	Danio rerio	35.24	9.00e-92	329.00
IUUC-Dno-029034	Dasypus novemcinctus	34.28	3.00e-113	400.00
IUUC-Dor-030479	Dipodomys ordii	36.32	2.00e-57	215.00
IUUC-Dse-031467	Dothistroma septosporum	49.87	0.00e+00	710.00
IUUC-Dme-032075	Drosophila melanogaster	36.75	5.00e-106	377.00
IUUC-Ete-032865	Echinops telfairi	32.08	1.00e-88	319.00
IUUC-Eca-034059	Equus caballus	34.07	8.00e-113	399.00
IUUC-Eeu-035304	Erinaceus europaeus	35.07	4.00e-109	387.00
IUUC-Fca-035515	Felis catus	34.03	5.00e-112	397.00
IUUC-Fal-037271	Ficedula albicollis	35.15	1.00e-117	415.00
IUUC-Fox-037745	Fusarium oxysporum	54.86	0.00e+00	789.00
IUUC-Fso-038158	Fusarium solani	55.28	0.00e+00	783.00
IUUC-Gmo-039071	Gadus morhua	31.61	1.00e-96	345.00
IUUC-Ggr-040098	Gaeumannomyces graminis	52.10	0.00e+00	723.00
IUUC-Gga-040635	Gallus gallus	34.77	8.00e-119	419.00
IUUC-Gac-042528	Gasterosteus aculeatus	33.08	3.00e-100	357.00
IUUC-Gma-043614	Glycine max	32.94	8.00e-98	349.00
IUUC-Ggo-044602	Gorilla gorilla	33.91	6.00e-111	393.00
IUUC-Hsa-045959	Homo sapiens	33.91	6.00e-111	393.00
IUUC-Hvu-047563	Hordeum vulgare	36.53	2.00e-94	338.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	33.99	4.00e-112	397.00
IUUC-Kpa-049156	Komagataella pastoris	37.47	5.00e-136	476.00
IUUC-Lch-049648	Latimeria chalumnae	33.72	7.00e-106	376.00
IUUC-Lpe-051523	Leersia perrieri	32.52	3.00e-92	331.00
IUUC-Loc-052072	Lepisosteus oculatus	31.89	3.00e-96	344.00
IUUC-Lma-053216	Leptosphaeria maculans	55.43	0.00e+00	814.00
IUUC-Laf-054327	Loxodonta africana	33.94	9.00e-112	396.00
IUUC-Mcc-055443	Macaca mulatta	34.03	3.00e-111	394.00
IUUC-Meu-056298	Macropus eugenii	32.71	2.00e-68	252.00
IUUC-Mor-057106	Magnaporthe oryzae	54.73	0.00e+00	789.00
IUUC-Mpo-057589	Magnaporthe poae	53.86	0.00e+00	738.00
IUUC-Mtr-058680	Medicago truncatula	36.88	1.00e-101	362.00
IUUC-Mla-058903	Melampsora laricipopulina	41.32	1.00e-150	525.00
IUUC-Mga-059669	Meleagris gallopavo	34.60	3.00e-114	404.00
IUUC-Mvi-060476	Microbotryum violaceum	40.69	1.00e-148	518.00
IUUC-Mmr-060575	Microcebus murinus	34.03	9.00e-112	396.00
IUUC-Mdo-062183	Monodelphis domestica	33.92	7.00e-114	403.00
IUUC-Mmu-063592	Mus musculus	33.91	5.00e-112	397.00
IUUC-Mac-065634	Musa acuminata	35.25	5.00e-53	201.00
IUUC-Mpu-066082	Mustela putorius furo	34.47	7.00e-114	403.00
IUUC-Mlu-067345	Myotis lucifugus	33.54	7.00e-109	386.00
IUUC-Nfi-068558	Neosartorya fischeri	91.53	0.00e+00	1377.00
IUUC-Ncr-068960	Neurospora crassa	54.15	0.00e+00	754.00
IUUC-Nle-070173	Nomascus leucogenys	34.39	8.00e-113	399.00
IUUC-Opr-070556	Ochotona princeps	33.95	4.00e-112	397.00
IUUC-Ont-071502	Oreochromis niloticus	33.59	1.00e-101	362.00
IUUC-Oan-072959	Ornithorhynchus anatinus	48.84	2.00e-38	150.00
IUUC-Ocu-074861	Oryctolagus cuniculus	34.43	2.00e-113	401.00
IUUC-Oba-075109	Oryza barthii	32.94	1.00e-95	342.00
IUUC-Obr-076292	Oryza brachyantha	33.12	4.00e-93	334.00
IUUC-Ogl-077065	Oryza glaberrima	34.20	3.00e-103	367.00
IUUC-Ogu-078776	Oryza glumaepatula	33.20	1.00e-99	355.00
IUUC-Oin-080048	Oryza indica	34.59	2.00e-103	368.00
IUUC-Olo-080711	Oryza longistaminata	32.48	3.00e-93	334.00
IUUC-Ome-081506	Oryza meridionalis	32.94	1.00e-95	342.00
IUUC-Oni-082320	Oryza nivara	36.11	5.00e-95	340.00
IUUC-Opu-083801	Oryza punctata	32.55	2.00e-89	322.00
IUUC-Oru-085139	Oryza rufipogon	35.95	4.00e-95	340.00
IUUC-Osa-085713	Oryza sativa	34.33	2.00e-104	371.00
IUUC-Ola-086951	Oryzias latipes	32.18	1.00e-92	333.00
IUUC-Olu-087822	Ostreococcus lucimarinus	33.70	6.00e-84	303.00
IUUC-Oga-088625	Otolemur garnettii	33.78	4.00e-111	394.00
IUUC-Oar-089995	Ovis aries	33.42	8.00e-110	389.00
IUUC-Ptr-090640	Pan troglodytes	34.88	1.00e-114	405.00
IUUC-Pan-091974	Papio anubis	33.90	4.00e-111	394.00
IUUC-Psi-093957	Pelodiscus sinensis	34.65	2.00e-118	418.00
IUUC-Pma-094242	Petromyzon marinus	40.26	2.00e-71	260.00
IUUC-Pno-094835	Phaeosphaeria nodorum	56.43	0.00e+00	838.00
IUUC-Ppa-095901	Physcomitrella patens	36.01	1.00e-118	419.00
IUUC-Pfo-097148	Poecilia formosa	33.76	5.00e-100	357.00
IUUC-Pab-098068	Pongo abelii	37.40	2.00e-102	364.00
IUUC-Pop-098943	Populus trichocarpa	33.46	1.00e-100	359.00
IUUC-Pca-100738	Procavia capensis	31.91	3.00e-101	361.00
IUUC-Ppe-101315	Prunus persica	32.30	4.00e-97	347.00
IUUC-Pva-102154	Pteropus vampyrus	33.29	2.00e-108	384.00
IUUC-Pgr-103343	Puccinia graminis	38.61	1.00e-113	402.00
IUUC-Ptt-103928	Puccinia triticina	32.99	6.00e-106	376.00
IUUC-Pte-104306	Pyrenophora teres	54.96	0.00e+00	808.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	54.83	0.00e+00	815.00
IUUC-Rno-105801	Rattus norvegicus	33.91	4.00e-112	397.00
IUUC-Sce-106304	Saccharomyces cerevisiae	34.93	4.00e-93	334.00
IUUC-Sha-107635	Sarcophilus harrisii	33.80	9.00e-112	396.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	40.52	7.00e-145	506.00
IUUC-Spo-108144	Schizosaccharomyces pombe	37.72	2.00e-141	494.00
IUUC-Smo-108703	Selaginella moellendorffii	35.46	8.00e-104	369.00
IUUC-Sit-110728	Setaria italica	32.99	1.00e-99	355.00
IUUC-Sly-111523	Solanum lycopersicum	34.29	3.00e-109	387.00
IUUC-Sar-113733	Sorex araneus	37.93	1.00e-51	196.00
IUUC-Sbi-114419	Sorghum bicolor	32.81	3.00e-99	354.00
IUUC-Sre-115225	Sporisorium reilianum	38.86	8.00e-143	499.00
IUUC-Ssc-115686	Sus scrofa	33.87	4.00e-111	394.00
IUUC-Tgu-117346	Taeniopygia guttata	34.40	1.00e-113	402.00
IUUC-Tru-118350	Takifugu rubripes	31.50	5.00e-97	347.00
IUUC-Tsy-119278	Tarsius syrichta	33.03	7.00e-81	293.00
IUUC-Tni-120658	Tetraodon nigroviridis	32.01	8.00e-93	333.00
IUUC-Tca-121585	Theobroma cacao	33.38	2.00e-97	348.00
IUUC-Tre-122043	Trichoderma reesei	53.76	0.00e+00	740.00
IUUC-Tvi-122303	Trichoderma virens	53.49	0.00e+00	759.00
IUUC-Tae-123798	Triticum aestivum	36.85	3.00e-96	344.00
IUUC-Tur-126732	Triticum urartu	33.22	1.00e-83	302.00
IUUC-Tme-126909	Tuber melanosporum	53.93	0.00e+00	777.00
IUUC-Tbe-127261	Tupaia belangeri	31.65	7.00e-76	276.00
IUUC-Ttr-128295	Tursiops truncatus	31.88	2.00e-72	265.00
IUUC-Uma-129599	Ustilago maydis	40.47	2.00e-145	508.00
IUUC-Vda-129688	Verticillium dahliae	52.05	0.00e+00	733.00
IUUC-Vpa-130170	Vicugna pacos	37.16	1.00e-39	156.00
IUUC-Vvi-131116	Vitis vinifera	33.55	4.00e-99	353.00
IUUC-Xtr-131953	Xenopus tropicalis	35.58	6.00e-100	357.00
IUUC-Xma-133837	Xiphophorus maculatus	33.63	3.00e-100	358.00
IUUC-Yli-134510	Yarrowia lipolytica	41.72	3.00e-149	520.00
IUUC-Zma-135786	Zea mays	33.03	1.00e-94	338.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence