iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052520

Ensembl Protein ID

ENSLOCP00000009499.1

UniProt Accession

W5MM90; W5MM90_LEPOC

Genbank Protein ID

ENSLOCP00000009499

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01034726

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000007807.1	ENSLOCT00000009510.1	ENSLOCP00000009499.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.30e-45	154.0	393	846
UBD/Alpha-Helix/UBA	5.40e-17	61.5	717	755

Active Site

Position(s)	Description	Evidence
316	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
809	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 64   kkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlks 152
           ++  ++pr++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++++  ++ +++ +++
   Q: 393  DQVGIAPRMFKALIGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSSDNPTEAYRFLMEE 452
           566799**************************************.............................667788999******* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkk 214
           +i+c++ ++v+ ++   + l+lpvp+++ t++e                            ++ cL++f+++e+le+   ++++  ++k
   Q: 453  RIVCQQSQRVKYTQRVDYILQLPVPMEHATNTEelqeyerrrreaeetlsppppavravvPFSVCLAAFSEPETLEE---FWSSALQAK 538
           ***************************9998889******************************************7...********* PP
   S: 215  qeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.................................... 267
           ++a+k++++ ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls                                         
   Q: 539  STASKTTRFASFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDSLDLSALRGAglqpgeeelpdlappplvtpdvevkgipggfhgnee 626
           *************************997.*******************87777888888888888888888888888888888888888 PP
   S: 268  .....................................................................................peek 271
                                                                                                p   
   Q: 627  ddslcspllfsasapvldestvgqliemgfpieacrkavyytgntgidsamnwvmthmddpdfsaplvlpgsssapggtptsqttP--- 712
           88888888888888888777777777777777777777777777777777777777777777777777777777766666666651... PP
   S: 272  qke...........................................................................kkkYeLiavvv 285
             +                                                                           + kYeL+a ++
   Q: 713  --TesvseehlatiismgfsrdqasralratsnvleravdwifshlddldsmdvsegrsaadsvsereppqgprvrdgPGKYELFAFIS 799
           ..0444556666666666666666666777777777777777777777777777777888888888889999999999*********** PP
   S: 286  HsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           H+G s+ +GHYv+++k+ +++W+ f+D+kV ++  e+  +   + +Y++fY+r
   Q: 800  HMGsSTMCGHYVCHIKK-NDQWVIFNDQKVCAS--EKPPK---DLGYLYFYRR 846
           *****************.999*********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +e+ l+ +++MGF+r++a +aLra++n le+Av++++++
   Q: 717  SEEHLATIISMGFSRDQASRALRATSNVLERAVDWIFSH 755
           7899*********************************97 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MSDLGEVLMS VLSTIRVPRP GDSVHKEECA FSFASPDSEG GLYVCMNTFL GFGAQFVERH 60
YRRTGQRAFL HIKRTRRPQK EEENGSGAGD PPKKKPTRLA IGIEGGFDVS EQDQYDQEVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGGACC TAGGCGAAGT GCTGATGTCG GTATTGTCCA CGATCCGTGT CCCACGGCCC 60
GGGGACAGCG TTCACAAGGA AGAGTGCGCT TTCTCTTTCG CCAGTCCGGT GAGTCCAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	64.11	0.00e+00	1078.00
IUUC-Apl-003774	Anas platyrhynchos	63.25	0.00e+00	1032.00
IUUC-Ame-011893	Astyanax mexicanus	70.00	0.00e+00	1045.00
IUUC-Bta-013179	Bos taurus	64.00	0.00e+00	1069.00
IUUC-Cja-019063	Callithrix jacchus	63.11	0.00e+00	1070.00
IUUC-Dre-027982	Danio rerio	70.89	0.00e+00	1139.00
IUUC-Dno-029034	Dasypus novemcinctus	63.13	0.00e+00	1066.00
IUUC-Ete-032865	Echinops telfairi	59.08	0.00e+00	966.00
IUUC-Eca-034059	Equus caballus	63.86	0.00e+00	1068.00
IUUC-Eeu-035304	Erinaceus europaeus	60.16	0.00e+00	948.00
IUUC-Fca-035515	Felis catus	64.23	0.00e+00	1073.00
IUUC-Gmo-039071	Gadus morhua	71.84	0.00e+00	1115.00
IUUC-Gga-040635	Gallus gallus	63.45	0.00e+00	1093.00
IUUC-Gac-042528	Gasterosteus aculeatus	67.93	0.00e+00	1118.00
IUUC-Ggo-044602	Gorilla gorilla	63.76	0.00e+00	1060.00
IUUC-Hsa-045959	Homo sapiens	63.76	0.00e+00	1060.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	63.11	0.00e+00	1065.00
IUUC-Laf-054327	Loxodonta africana	63.65	0.00e+00	1059.00
IUUC-Mcc-055443	Macaca mulatta	63.02	0.00e+00	1059.00
IUUC-Mga-059669	Meleagris gallopavo	63.01	0.00e+00	1028.00
IUUC-Mmr-060575	Microcebus murinus	63.76	0.00e+00	1065.00
IUUC-Mmu-063592	Mus musculus	63.65	0.00e+00	1062.00
IUUC-Mlu-067345	Myotis lucifugus	62.76	0.00e+00	1061.00
IUUC-Opr-070556	Ochotona princeps	64.06	0.00e+00	1080.00
IUUC-Ont-071502	Oreochromis niloticus	70.31	0.00e+00	1132.00
IUUC-Ola-086951	Oryzias latipes	70.89	0.00e+00	1108.00
IUUC-Oga-088625	Otolemur garnettii	62.76	0.00e+00	1057.00
IUUC-Oar-089995	Ovis aries	63.56	0.00e+00	1081.00
IUUC-Ptr-090640	Pan troglodytes	62.49	0.00e+00	1052.00
IUUC-Pan-091974	Papio anubis	62.37	0.00e+00	1066.00
IUUC-Pfo-097148	Poecilia formosa	70.66	0.00e+00	1130.00
IUUC-Pab-098068	Pongo abelii	58.65	0.00e+00	917.00
IUUC-Pva-102154	Pteropus vampyrus	63.53	0.00e+00	1057.00
IUUC-Rno-105801	Rattus norvegicus	64.11	0.00e+00	1066.00
IUUC-Sha-107635	Sarcophilus harrisii	62.28	0.00e+00	1036.00
IUUC-Ssc-115686	Sus scrofa	62.76	0.00e+00	1056.00
IUUC-Tgu-117346	Taeniopygia guttata	62.80	0.00e+00	1058.00
IUUC-Tru-118350	Takifugu rubripes	70.25	0.00e+00	1132.00
IUUC-Tni-120658	Tetraodon nigroviridis	71.49	0.00e+00	1127.00
IUUC-Tme-126909	Tuber melanosporum	31.56	1.00e-101	364.00
IUUC-Xtr-131953	Xenopus tropicalis	61.80	0.00e+00	1007.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence