iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020398

Ensembl Protein ID

ENSCAFP00000020505.3

UniProt Accession

F1PPK2; F1PPK2_CANLF

Genbank Protein ID

ENSCAFP00000020505

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03005173

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000013920.3	ENSCAFT00000022081.3	ENSCAFP00000020505.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-12	47.0	66	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 66   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 123
           67899************************.*********98..788899*********997 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MQIKRAKCKD HFASCVEDGF EGDKTGGSSP EALHRPYGCD VEPQALNEAI RWSSKENLLG 60
ATESDPNLFV ALYDFVASGD NTLSITKGEK LRVLGYNQNG EWSEVRSKNG QGWVPSNYIT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCTGTAAA GCCTATCAAT TCCATTTTGG AATTTGGATT TTTAAGTTCT TCCACTTTGT 60
CTTCATGACA CCATCCAAGC CAACTGGAGC CCATTCCTGA ACTGCTACAT ATTTGCCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0071300--P:cellular response to retinoic acid
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	99.67	0.00e+00	1260.00
IUUC-Atr-002778	Amborella trichopoda	32.49	9.00e-23	102.00
IUUC-Apl-003389	Anas platyrhynchos	96.74	0.00e+00	1228.00
IUUC-Bta-013370	Bos taurus	98.58	0.00e+00	1271.00
IUUC-Cja-018894	Callithrix jacchus	98.53	0.00e+00	1240.00
IUUC-Cpo-022367	Cavia porcellus	96.92	0.00e+00	1221.00
IUUC-Csa-023386	Chlorocebus sabaeus	99.02	0.00e+00	1253.00
IUUC-Cho-024714	Choloepus hoffmanni	98.86	0.00e+00	1220.00
IUUC-Dre-027741	Danio rerio	83.08	0.00e+00	1064.00
IUUC-Dno-029246	Dasypus novemcinctus	99.19	0.00e+00	1256.00
IUUC-Dor-030416	Dipodomys ordii	88.35	0.00e+00	1126.00
IUUC-Ete-032899	Echinops telfairi	89.85	3.00e-144	506.00
IUUC-Eca-033387	Equus caballus	99.53	0.00e+00	1302.00
IUUC-Eeu-035058	Erinaceus europaeus	88.58	0.00e+00	1095.00
IUUC-Fca-036578	Felis catus	98.52	0.00e+00	1192.00
IUUC-Fal-037491	Ficedula albicollis	97.07	0.00e+00	1228.00
IUUC-Gmo-038509	Gadus morhua	87.11	0.00e+00	1047.00
IUUC-Gga-040638	Gallus gallus	95.77	0.00e+00	1213.00
IUUC-Gac-042550	Gasterosteus aculeatus	86.46	0.00e+00	1065.00
IUUC-Ggo-044487	Gorilla gorilla	99.21	0.00e+00	1299.00
IUUC-Hsa-046636	Homo sapiens	99.21	0.00e+00	1299.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	98.43	0.00e+00	1290.00
IUUC-Lch-049530	Latimeria chalumnae	91.22	0.00e+00	1181.00
IUUC-Loc-051933	Lepisosteus oculatus	84.41	0.00e+00	1134.00
IUUC-Laf-053802	Loxodonta africana	98.90	0.00e+00	1328.00
IUUC-Mcc-054836	Macaca mulatta	99.06	0.00e+00	1298.00
IUUC-Mga-059277	Meleagris gallopavo	96.58	0.00e+00	1224.00
IUUC-Mmr-061206	Microcebus murinus	98.43	0.00e+00	1252.00
IUUC-Mdo-062281	Monodelphis domestica	91.35	0.00e+00	1773.00
IUUC-Mmu-063847	Mus musculus	95.91	0.00e+00	1212.00
IUUC-Mpu-066309	Mustela putorius furo	98.34	0.00e+00	1859.00
IUUC-Mlu-068070	Myotis lucifugus	98.37	0.00e+00	1235.00
IUUC-Nle-070062	Nomascus leucogenys	97.27	0.00e+00	1901.00
IUUC-Ont-072440	Oreochromis niloticus	84.82	0.00e+00	1050.00
IUUC-Oan-073526	Ornithorhynchus anatinus	96.09	0.00e+00	1218.00
IUUC-Ocu-074051	Oryctolagus cuniculus	97.56	0.00e+00	1228.00
IUUC-Ogu-078962	Oryza glumaepatula	34.39	1.00e-23	105.00
IUUC-Oin-079172	Oryza indica	34.39	1.00e-23	105.00
IUUC-Olo-080286	Oryza longistaminata	34.39	1.00e-23	105.00
IUUC-Opu-083538	Oryza punctata	34.84	2.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	34.39	8.00e-24	105.00
IUUC-Osa-085779	Oryza sativa	34.39	8.00e-24	105.00
IUUC-Ola-086752	Oryzias latipes	95.27	0.00e+00	915.00
IUUC-Oga-088767	Otolemur garnettii	87.84	0.00e+00	1083.00
IUUC-Oar-089800	Ovis aries	98.86	0.00e+00	1229.00
IUUC-Ptr-090857	Pan troglodytes	97.37	0.00e+00	1903.00
IUUC-Pan-092279	Papio anubis	99.02	0.00e+00	1253.00
IUUC-Psi-093573	Pelodiscus sinensis	96.43	0.00e+00	1223.00
IUUC-Pfo-096543	Poecilia formosa	83.39	0.00e+00	1031.00
IUUC-Pab-097949	Pongo abelii	99.35	0.00e+00	1255.00
IUUC-Pca-100370	Procavia capensis	99.18	0.00e+00	769.00
IUUC-Pva-103220	Pteropus vampyrus	88.52	0.00e+00	1135.00
IUUC-Rno-105924	Rattus norvegicus	95.81	0.00e+00	1179.00
IUUC-Sha-107114	Sarcophilus harrisii	95.45	0.00e+00	1178.00
IUUC-Sit-110444	Setaria italica	32.00	9.00e-19	89.00
IUUC-Ssc-115968	Sus scrofa	99.21	0.00e+00	1299.00
IUUC-Tgu-117301	Taeniopygia guttata	96.59	0.00e+00	1225.00
IUUC-Tru-118410	Takifugu rubripes	82.83	0.00e+00	1078.00
IUUC-Tni-119991	Tetraodon nigroviridis	82.68	0.00e+00	1074.00
IUUC-Tca-121389	Theobroma cacao	33.33	3.00e-23	103.00
IUUC-Tbe-127362	Tupaia belangeri	99.06	0.00e+00	1258.00
IUUC-Ttr-129291	Tursiops truncatus	99.19	0.00e+00	1251.00
IUUC-Vpa-130800	Vicugna pacos	95.92	0.00e+00	1243.00
IUUC-Xtr-132965	Xenopus tropicalis	89.29	0.00e+00	1122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence