• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
iUUCD ID IUUC-Ocu-074926
UUCD1 version UUC-OrC-01061
Ensembl Protein ID ENSOCUP00000015687.1
UniProt Accession P40826; UBP14_RABIT
Genbank Protein ID AAA96133.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
Genbank Nucleotide ID L37420
Gene Name USP14; TGT
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000011595.3 ENSOCUT00000029186.2 ENSOCUP00000015687.1
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 14536023
Classification
Family E-value Score Start End
DUB/USP 4.60e-65 220.1 105 479
ULD/UDP/UBQ/UBQ_Other 2.60e-10 40.1 5 74
Active Site
Position(s) Description Evidence
114 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
434 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+          e+++ +e++++a    ++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEA--------IEDDSVKETDSSAAAVAPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQL 272
           999*********************44........334444455666788899*************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 273  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 354
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 355  YELCTPelqekmvsfrskfkdiedkkvnqqP-----NasdkksspqkevryepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 438
           ******6666666666666666555555551.....0555556666677777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 439  VKRKHDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 479
           **************************988************ PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + + +++++n +++  ++K +++ ++g++p++qr ++kG  L+dd ++++ ++k+g+ti+++ +
   Q: 5    SVTVKWGKEKFGGVELNTDEPPMVFKAQLFALTGVQPARQRVMVKGGTLKDD-DWGNIKIKNGMTILMMGS 74
           69***********************************************999.9**************975 PP
   
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
 Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
Protein Sequence
(Fasta)
MPLYSVTVKW GKEKFGGVEL NTDEPPMVFK AQLFALTGVQ PARQRVMVKG GTLKDDDWGN 60
IKIKNGMTIL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074926|ULD,UBQ_Other;DUB,USP|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCGCGCAC CTGCTCGGGG CGCTCGGGCC GCGTGCTGGC CCGCGCCTCC TCCTCCCTGC 60
TCCTGCCGCG CTCTCGCCCC GCCTGCTCCT GCCGCGCCTT CCCCGCCCTT CCTCTCGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074926|ULD,UBQ_Other;DUB,USP|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
SMART

SM00213--UBQ
Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG ocu:100009078
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000893 Aegilops tauschii 29.67 3.00e-64 239.00
IUUC-Aml-002053 Ailuropoda melanoleuca 95.93 0.00e+00 923.00
IUUC-Atr-002725 Amborella trichopoda 42.02 2.00e-102 365.00
IUUC-Apl-004031 Anas platyrhynchos 90.63 0.00e+00 893.00
IUUC-Aca-004361 Anolis carolinensis 88.48 0.00e+00 909.00
IUUC-Aly-006078 Arabidopsis lyrata 41.68 1.00e-110 392.00
IUUC-Ath-007623 Arabidopsis thaliana 41.87 4.00e-111 394.00
IUUC-Ago-007796 Ashbya gossypii 32.49 1.00e-59 223.00
IUUC-Acl-008258 Aspergillus clavatus 37.63 2.00e-66 246.00
IUUC-Afl-008732 Aspergillus flavus 33.15 3.00e-78 286.00
IUUC-Afu-008755 Aspergillus fumigatus 34.84 1.00e-79 290.00
IUUC-Ani-009148 Aspergillus nidulans 39.13 5.00e-71 261.00
IUUC-Ang-009878 Aspergillus niger 38.21 6.00e-66 245.00
IUUC-Aor-010239 Aspergillus oryzae 33.15 3.00e-78 286.00
IUUC-Ate-010243 Aspergillus terreus 33.75 1.00e-71 263.00
IUUC-Ame-011327 Astyanax mexicanus 50.60 9.00e-128 450.00
IUUC-Bgr-012231 Blumeria graminis 33.27 5.00e-71 261.00
IUUC-Bta-012553 Bos taurus 96.15 0.00e+00 947.00
IUUC-Bci-013606 Botrytis cinerea 40.27 4.00e-70 258.00
IUUC-Bdi-014567 Brachypodium distachyon 42.80 7.00e-113 400.00
IUUC-Bol-016127 Brassica oleracea 42.28 9.00e-113 400.00
IUUC-Bra-017501 Brassica rapa 42.08 6.00e-112 397.00
IUUC-Cel-018140 Caenorhabditis elegans 41.24 1.00e-100 360.00
IUUC-Cja-019516 Callithrix jacchus 96.37 0.00e+00 949.00
IUUC-Cfa-020808 Canis familiaris 97.37 0.00e+00 956.00
IUUC-Cpo-021688 Cavia porcellus 96.55 0.00e+00 946.00
IUUC-Cre-022663 Chlamydomonas reinhardtii 37.85 6.00e-83 301.00
IUUC-Csa-023429 Chlorocebus sabaeus 97.16 0.00e+00 930.00
IUUC-Cho-024347 Choloepus hoffmanni 96.35 0.00e+00 947.00
IUUC-Cin-025198 Ciona intestinalis 55.03 4.00e-152 531.00
IUUC-Csv-026007 Ciona savignyi 52.92 2.00e-154 538.00
IUUC-Cgl-026757 Colletotrichum gloeosporioides 38.96 6.00e-64 238.00
IUUC-Cne-026963 Cryptococcus neoformans 34.54 4.00e-76 278.00
IUUC-Cme-027240 Cyanidioschyzon merolae 31.07 3.00e-60 226.00
IUUC-Dre-027647 Danio rerio 82.00 0.00e+00 835.00
IUUC-Dno-029967 Dasypus novemcinctus 96.56 0.00e+00 926.00
IUUC-Dor-030886 Dipodomys ordii 90.23 0.00e+00 760.00
IUUC-Dse-031466 Dothistroma septosporum 35.92 2.00e-58 220.00
IUUC-Dme-032079 Drosophila melanogaster 54.64 1.00e-159 555.00
IUUC-Ete-032351 Echinops telfairi 85.19 0.00e+00 853.00
IUUC-Eca-033461 Equus caballus 96.15 0.00e+00 989.00
IUUC-Eeu-035220 Erinaceus europaeus 73.16 0.00e+00 684.00
IUUC-Fca-036210 Felis catus 97.57 0.00e+00 958.00
IUUC-Fal-037528 Ficedula albicollis 90.45 0.00e+00 873.00
IUUC-Fox-037805 Fusarium oxysporum 40.00 6.00e-71 261.00
IUUC-Fso-038177 Fusarium solani 38.44 4.00e-68 252.00
IUUC-Gmo-038953 Gadus morhua 78.21 0.00e+00 775.00
IUUC-Ggr-039972 Gaeumannomyces graminis 39.30 1.00e-64 240.00
IUUC-Gga-040462 Gallus gallus 89.86 0.00e+00 887.00
IUUC-Gac-041312 Gasterosteus aculeatus 81.28 0.00e+00 806.00
IUUC-Gma-043255 Glycine max 42.71 4.00e-109 388.00
IUUC-Ggo-045458 Gorilla gorilla 81.21 0.00e+00 785.00
IUUC-Hsa-045706 Homo sapiens 97.37 0.00e+00 933.00
IUUC-Hvu-047821 Hordeum vulgare 45.83 4.00e-57 214.00
IUUC-Itr-048654 Ictidomys tridecemlineatus 94.94 0.00e+00 949.00
IUUC-Lch-050464 Latimeria chalumnae 82.00 0.00e+00 823.00
IUUC-Lpe-051419 Leersia perrieri 41.98 4.00e-109 387.00
IUUC-Loc-052732 Lepisosteus oculatus 80.65 0.00e+00 845.00
IUUC-Lma-053177 Leptosphaeria maculans 41.13 2.00e-70 259.00
IUUC-Laf-053822 Loxodonta africana 96.35 0.00e+00 946.00
IUUC-Mcc-055893 Macaca mulatta 97.36 0.00e+00 931.00
IUUC-Meu-056307 Macropus eugenii 82.04 0.00e+00 792.00
IUUC-Mor-057171 Magnaporthe oryzae 38.46 7.00e-69 254.00
IUUC-Mpo-057415 Magnaporthe poae 39.53 7.00e-71 261.00
IUUC-Mtr-057901 Medicago truncatula 43.08 8.00e-112 397.00
IUUC-Mla-058897 Melampsora laricipopulina 39.47 3.00e-75 275.00
IUUC-Mga-060016 Meleagris gallopavo 90.22 0.00e+00 889.00
IUUC-Mvi-060562 Microbotryum violaceum 39.14 6.00e-68 251.00
IUUC-Mmr-060624 Microcebus murinus 96.76 0.00e+00 998.00
IUUC-Mdo-061809 Monodelphis domestica 92.34 0.00e+00 896.00
IUUC-Mmu-063869 Mus musculus 95.75 0.00e+00 940.00
IUUC-Mac-064876 Musa acuminata 39.36 1.00e-96 347.00
IUUC-Mpu-066480 Mustela putorius furo 96.96 0.00e+00 954.00
IUUC-Mlu-067866 Myotis lucifugus 95.75 0.00e+00 952.00
IUUC-Nfi-068393 Neosartorya fischeri 36.64 2.00e-65 243.00
IUUC-Ncr-068815 Neurospora crassa 38.61 2.00e-70 259.00
IUUC-Nle-070121 Nomascus leucogenys 97.23 9.00e-139 485.00
IUUC-Opr-070712 Ochotona princeps 78.97 2.00e-180 625.00
IUUC-Ont-071544 Oreochromis niloticus 81.63 0.00e+00 774.00
IUUC-Oan-073635 Ornithorhynchus anatinus 91.10 0.00e+00 754.00
IUUC-Oba-075633 Oryza barthii 41.68 2.00e-108 385.00
IUUC-Obr-076423 Oryza brachyantha 41.90 6.00e-112 397.00
IUUC-Ogl-077913 Oryza glaberrima 41.70 5.00e-111 394.00
IUUC-Ogu-078435 Oryza glumaepatula 41.68 2.00e-108 385.00
IUUC-Oin-080072 Oryza indica 41.86 1.00e-108 386.00
IUUC-Olo-080535 Oryza longistaminata 39.08 3.00e-93 335.00
IUUC-Ome-081309 Oryza meridionalis 41.68 2.00e-108 385.00
IUUC-Oni-083113 Oryza nivara 41.68 2.00e-108 385.00
IUUC-Opu-083168 Oryza punctata 40.74 8.00e-103 367.00
IUUC-Oru-084253 Oryza rufipogon 41.68 2.00e-108 385.00
IUUC-Osa-085554 Oryza sativa 41.70 4.00e-111 394.00
IUUC-Ola-086998 Oryzias latipes 80.89 0.00e+00 797.00
IUUC-Olu-087818 Ostreococcus lucimarinus 36.36 3.00e-71 262.00
IUUC-Oga-088571 Otolemur garnettii 96.75 0.00e+00 956.00
IUUC-Oar-089526 Ovis aries 95.93 0.00e+00 941.00
IUUC-Ptr-091433 Pan troglodytes 97.36 0.00e+00 931.00
IUUC-Pan-091966 Papio anubis 97.16 0.00e+00 930.00
IUUC-Psi-093458 Pelodiscus sinensis 88.98 0.00e+00 848.00
IUUC-Pma-094343 Petromyzon marinus 68.17 1.00e-119 422.00
IUUC-Pno-095109 Phaeosphaeria nodorum 39.43 7.00e-66 244.00
IUUC-Ppa-095756 Physcomitrella patens 43.98 4.00e-112 398.00
IUUC-Pfo-096514 Poecilia formosa 82.04 0.00e+00 789.00
IUUC-Pab-098477 Pongo abelii 85.11 0.00e+00 736.00
IUUC-Pop-099221 Populus trichocarpa 41.25 4.00e-103 368.00
IUUC-Pca-100791 Procavia capensis 80.42 2.00e-180 624.00
IUUC-Ppe-101812 Prunus persica 41.25 7.00e-107 380.00
IUUC-Pva-102462 Pteropus vampyrus 91.84 0.00e+00 768.00
IUUC-Pgr-103623 Puccinia graminis 40.52 1.00e-74 273.00
IUUC-Ptt-103767 Puccinia triticina 39.52 1.00e-68 253.00
IUUC-Pte-104109 Pyrenophora teres 40.58 6.00e-70 258.00
IUUC-Pyt-104766 Pyrenophora triticirepentis 40.96 6.00e-70 258.00
IUUC-Rno-105351 Rattus norvegicus 94.53 0.00e+00 899.00
IUUC-Sce-106168 Saccharomyces cerevisiae 32.47 5.00e-63 234.00
IUUC-Sha-107491 Sarcophilus harrisii 92.32 0.00e+00 915.00
IUUC-Sja-107769 Schizosaccharomyces japonicus 34.52 2.00e-78 286.00
IUUC-Spo-108174 Schizosaccharomyces pombe 37.25 5.00e-81 294.00
IUUC-Ssl-108659 Sclerotinia sclerotiorum 34.81 1.00e-84 306.00
IUUC-Smo-108805 Selaginella moellendorffii 43.15 6.00e-110 390.00
IUUC-Sit-110361 Setaria italica 42.83 7.00e-114 404.00
IUUC-Sly-110965 Solanum lycopersicum 41.12 5.00e-108 384.00
IUUC-Sar-113355 Sorex araneus 84.11 0.00e+00 664.00
IUUC-Sbi-114778 Sorghum bicolor 43.72 9.00e-115 407.00
IUUC-Sre-115011 Sporisorium reilianum 36.72 3.00e-62 232.00
IUUC-Ssc-116273 Sus scrofa 96.13 0.00e+00 932.00
IUUC-Tgu-117063 Taeniopygia guttata 89.82 0.00e+00 870.00
IUUC-Tru-118381 Takifugu rubripes 79.07 0.00e+00 798.00
IUUC-Tsy-119076 Tarsius syrichta 80.24 9.00e-118 416.00
IUUC-Tni-119941 Tetraodon nigroviridis 80.37 0.00e+00 790.00
IUUC-Tca-121246 Theobroma cacao 41.37 6.00e-109 387.00
IUUC-Tre-121969 Trichoderma reesei 34.90 2.00e-76 280.00
IUUC-Tvi-122543 Trichoderma virens 34.04 9.00e-75 274.00
IUUC-Tae-125484 Triticum aestivum 42.14 1.00e-109 390.00
IUUC-Tur-126128 Triticum urartu 31.57 9.00e-67 247.00
IUUC-Tbe-128030 Tupaia belangeri 89.34 0.00e+00 848.00
IUUC-Ttr-128701 Tursiops truncatus 95.52 0.00e+00 768.00
IUUC-Uma-129657 Ustilago maydis 37.18 4.00e-65 242.00
IUUC-Vda-129723 Verticillium dahliae 32.17 5.00e-72 265.00
IUUC-Vpa-130284 Vicugna pacos 69.06 0.00e+00 628.00
IUUC-Vvi-131037 Vitis vinifera 42.32 1.00e-108 386.00
IUUC-Xtr-132235 Xenopus tropicalis 86.26 0.00e+00 888.00
IUUC-Xma-133840 Xiphophorus maculatus 82.04 0.00e+00 814.00
IUUC-Yli-134453 Yarrowia lipolytica 37.05 2.00e-82 299.00
IUUC-Zma-135669 Zea mays 36.38 7.00e-96 344.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved