iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111447

Ensembl Protein ID

Solyc07g032100.2.1

UniProt Accession

K4CDF4; K4CDF4_SOLLC

Protein Name

Coatomer subunit alpha

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc07g032100.2	Solyc07g032100.2.1	Solyc07g032100.2.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-37	126.4	50	85
UBD/Beta-Prp	4.10e-77	260.0	3	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           H ++v++++f  s +l+vsG+dD +ikvW+++ +++
   Q: 50   HDGPVRGVHFhkSQPLFVSGGDDYKIKVWNYKLHRC 85
           99*********7559***************876666 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           t +++++++++ + f+ ++++++++  +g i++wd+++g+l+ ++ +h+++v+ v f+++++++v+g++D+ ikvw+++   c+ tl gh 
   Q: 3    TKFETKSNRVKGLSFHTQRPWILASLHSGVIQLWDYRMGTLIDRFDEHDGPVRGVHFHKSQPLFVSGGDDYKIKVWNYKLHRCLFTLLGHL 93
           67889999*********************************************************************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl................... 166
           d++++++f+ +  ++vs+s+d+tir+w++++++c++ +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                   
   Q: 94   DYIRTVQFHHEYPWIVSASDDQTIRIWNWQSRTCIS-VLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIgalrkktispaddllrlsq 183
           ************************************.*********************************************999995555 PP
   S: 167  ...ktgkllrtl............tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsg 240
                      +            +g h++ v++ sf+++ + +vsg++d++vk+w +  ++   v+tl+gh +nv++v f+p+++++vs 
   Q: 184  mntD-------FfggvdavvkyvlEG-HDRGVNWASFHPTLPLIVSGADDRQVKIWRMNDTKAweVDTLRGHMNNVSCVLFHPRQDIIVSN 266
           5550.......455555555555365.********************************777668************************** PP
   S: 241  ssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           s+D+sir+Wd ++++ l+t+ +++++++  a  +++ n l++g  ds   ++kl++++p
   Q: 267  SEDKSIRVWDATKRTGLQTFRREHDRFWILAS-HPEMNLLAAG-HDSGMIVFKLERERP 323
           *******************************9.6666655555.689999999988765 PP

Organism

Solanum lycopersicum

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSN RVKGLSFHTQ RPWILASLHS GVIQLWDYRM GTLIDRFDEH DGPVRGVHFH 60
KSQPLFVSGG DDYKIKVWNY KLHRCLFTLL GHLDYIRTVQ FHHEYPWIVS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACACGAAAC ACGGATATTA TACTGCGGAA ATATATTAGC AAATAAAAGA GTCTTCCTTT 60
TTTCTAAAAA AGGGTCTTAA TATTAAAACT CATCAATTAC TACGTATGAA CAAGTAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

sly:101264027

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	74.74	0.00e+00	1943.00
IUUC-Aml-001758	Ailuropoda melanoleuca	54.57	0.00e+00	1365.00
IUUC-Ago-007992	Ashbya gossypii	43.39	0.00e+00	964.00
IUUC-Acl-008027	Aspergillus clavatus	46.86	0.00e+00	1115.00
IUUC-Afl-008644	Aspergillus flavus	46.60	0.00e+00	1111.00
IUUC-Afu-008964	Aspergillus fumigatus	47.23	0.00e+00	1128.00
IUUC-Ang-009756	Aspergillus niger	46.78	0.00e+00	1127.00
IUUC-Aor-010174	Aspergillus oryzae	46.60	0.00e+00	1112.00
IUUC-Ate-010302	Aspergillus terreus	47.35	0.00e+00	1144.00
IUUC-Ame-011229	Astyanax mexicanus	53.69	0.00e+00	1333.00
IUUC-Bgr-012300	Blumeria graminis	46.53	0.00e+00	1080.00
IUUC-Bta-012524	Bos taurus	55.04	0.00e+00	1358.00
IUUC-Cel-018115	Caenorhabditis elegans	56.46	0.00e+00	966.00
IUUC-Cja-019107	Callithrix jacchus	54.05	0.00e+00	1345.00
IUUC-Cfa-020675	Canis familiaris	54.23	0.00e+00	1339.00
IUUC-Cpo-021813	Cavia porcellus	55.13	0.00e+00	1375.00
IUUC-Csa-023523	Chlorocebus sabaeus	55.21	0.00e+00	1382.00
IUUC-Cme-027222	Cyanidioschyzon merolae	33.25	2.00e-169	589.00
IUUC-Dre-027421	Danio rerio	54.92	0.00e+00	1362.00
IUUC-Dno-029303	Dasypus novemcinctus	55.29	0.00e+00	1384.00
IUUC-Dor-030290	Dipodomys ordii	52.99	8.00e-165	573.00
IUUC-Dme-031945	Drosophila melanogaster	61.85	0.00e+00	1047.00
IUUC-Ete-032873	Echinops telfairi	53.02	0.00e+00	1214.00
IUUC-Eca-033773	Equus caballus	54.39	0.00e+00	1340.00
IUUC-Fca-035739	Felis catus	54.30	0.00e+00	1336.00
IUUC-Fso-038153	Fusarium solani	46.63	0.00e+00	1120.00
IUUC-Gmo-039602	Gadus morhua	50.89	0.00e+00	1242.00
IUUC-Gac-041318	Gasterosteus aculeatus	53.79	0.00e+00	1359.00
IUUC-Ggo-045029	Gorilla gorilla	54.81	0.00e+00	1372.00
IUUC-Hsa-046078	Homo sapiens	54.73	0.00e+00	1370.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	46.06	0.00e+00	763.00
IUUC-Kpa-049256	Komagataella pastoris	44.92	0.00e+00	1051.00
IUUC-Mcc-055836	Macaca mulatta	54.82	0.00e+00	1370.00
IUUC-Meu-056238	Macropus eugenii	56.51	0.00e+00	777.00
IUUC-Mmr-061102	Microcebus murinus	54.73	0.00e+00	1356.00
IUUC-Mdo-062594	Monodelphis domestica	55.69	0.00e+00	1400.00
IUUC-Mmu-063736	Mus musculus	54.61	0.00e+00	1366.00
IUUC-Nfi-068270	Neosartorya fischeri	47.19	0.00e+00	1116.00
IUUC-Ncr-068892	Neurospora crassa	46.71	0.00e+00	1098.00
IUUC-Ont-072488	Oreochromis niloticus	54.26	0.00e+00	1344.00
IUUC-Ocu-074211	Oryctolagus cuniculus	55.04	0.00e+00	1370.00
IUUC-Ola-086921	Oryzias latipes	53.98	0.00e+00	1342.00
IUUC-Oga-087991	Otolemur garnettii	51.97	0.00e+00	1276.00
IUUC-Oar-089590	Ovis aries	54.96	0.00e+00	1375.00
IUUC-Ptr-090808	Pan troglodytes	54.81	0.00e+00	1372.00
IUUC-Pan-092475	Papio anubis	55.00	0.00e+00	1374.00
IUUC-Pno-094839	Phaeosphaeria nodorum	45.45	0.00e+00	1045.00
IUUC-Pfo-097493	Poecilia formosa	53.90	0.00e+00	1339.00
IUUC-Pab-098497	Pongo abelii	55.13	0.00e+00	1381.00
IUUC-Pva-102126	Pteropus vampyrus	52.48	0.00e+00	1293.00
IUUC-Ptt-103978	Puccinia triticina	51.59	0.00e+00	828.00
IUUC-Rno-105428	Rattus norvegicus	55.09	0.00e+00	1375.00
IUUC-Sce-106464	Saccharomyces cerevisiae	41.82	0.00e+00	942.00
IUUC-Sha-107301	Sarcophilus harrisii	54.65	0.00e+00	1359.00
IUUC-Spo-108217	Schizosaccharomyces pombe	45.05	0.00e+00	1056.00
IUUC-Smo-109582	Selaginella moellendorffii	68.93	0.00e+00	1767.00
IUUC-Sar-113313	Sorex araneus	41.25	0.00e+00	637.00
IUUC-Ssc-115933	Sus scrofa	55.04	0.00e+00	1375.00
IUUC-Tru-117772	Takifugu rubripes	53.26	0.00e+00	1315.00
IUUC-Tca-121046	Theobroma cacao	84.12	0.00e+00	2145.00
IUUC-Tme-127170	Tuber melanosporum	47.52	0.00e+00	1176.00
IUUC-Ttr-128217	Tursiops truncatus	52.88	0.00e+00	1300.00
IUUC-Vpa-130537	Vicugna pacos	54.49	0.00e+00	1352.00
IUUC-Xtr-132857	Xenopus tropicalis	53.21	0.00e+00	1285.00
IUUC-Xma-133138	Xiphophorus maculatus	53.82	0.00e+00	1339.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence