iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062318

Ensembl Protein ID

ENSMODP00000015019.1

UniProt Accession

F7B9H2; F7B9H2_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000011985.1	ENSMODT00000015294.1	ENSMODP00000015019.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.70e-13	49.0	57	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++  +l+dyea+nd +L+  kG++++++    + ++W+ + +  ++++G +P+nFv+++e
   Q: 57   EHYAVALWDYEATNDRDLKVVKGEKLQIL---MKTGDWWLARSLVTKREGYVPSNFVTQVE 114
           678899***********************...999***********************997 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGVVSSKKLA KEKGKNQWNF KEPHIVFPKT PPPPLPPLVV FNHLTTPTPV LKPDQEEHYA 60
VALWDYEATN DRDLKVVKGE KLQILMKTGD WWLARSLVTK REGYVPSNFV TQVETLEVEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGTAG TGAGCAGCAA GAAACTGGCT AAGGAGAAAG GGAAGAATCA GTGGAATTTT 60
AAGGAGCCTC ATATCGTCTT CCCAAAGACG CCTCCCCCAC CTCTGCCTCC ATTGGTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mdo:100032697

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	78.23	0.00e+00	787.00
IUUC-Apl-003307	Anas platyrhynchos	76.24	0.00e+00	731.00
IUUC-Aca-004357	Anolis carolinensis	68.09	0.00e+00	664.00
IUUC-Ame-010642	Astyanax mexicanus	70.16	0.00e+00	684.00
IUUC-Bta-012400	Bos taurus	75.88	0.00e+00	793.00
IUUC-Cfa-021056	Canis familiaris	75.25	0.00e+00	798.00
IUUC-Cpo-021779	Cavia porcellus	79.51	0.00e+00	782.00
IUUC-Csa-023557	Chlorocebus sabaeus	78.35	0.00e+00	787.00
IUUC-Dre-027517	Danio rerio	69.49	0.00e+00	690.00
IUUC-Eca-034218	Equus caballus	78.02	0.00e+00	776.00
IUUC-Eeu-035095	Erinaceus europaeus	58.74	2.00e-170	592.00
IUUC-Fca-036015	Felis catus	74.26	0.00e+00	794.00
IUUC-Fal-036946	Ficedula albicollis	75.68	0.00e+00	729.00
IUUC-Gga-040822	Gallus gallus	75.00	0.00e+00	733.00
IUUC-Ggo-044608	Gorilla gorilla	77.00	0.00e+00	720.00
IUUC-Hsa-046719	Homo sapiens	77.37	0.00e+00	778.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	74.66	0.00e+00	775.00
IUUC-Lch-050114	Latimeria chalumnae	72.85	0.00e+00	698.00
IUUC-Loc-052326	Lepisosteus oculatus	65.81	0.00e+00	703.00
IUUC-Laf-053387	Loxodonta africana	75.50	0.00e+00	785.00
IUUC-Mcc-055026	Macaca mulatta	78.14	0.00e+00	786.00
IUUC-Mga-059427	Meleagris gallopavo	75.40	0.00e+00	722.00
IUUC-Mmr-061660	Microcebus murinus	74.46	0.00e+00	785.00
IUUC-Mmu-063325	Mus musculus	76.89	0.00e+00	801.00
IUUC-Mpu-066582	Mustela putorius furo	79.09	0.00e+00	793.00
IUUC-Nle-069624	Nomascus leucogenys	77.71	0.00e+00	772.00
IUUC-Opr-070656	Ochotona princeps	72.11	0.00e+00	730.00
IUUC-Ont-072266	Oreochromis niloticus	70.81	0.00e+00	674.00
IUUC-Ocu-073907	Oryctolagus cuniculus	75.15	0.00e+00	786.00
IUUC-Ogu-078119	Oryza glumaepatula	34.91	4.00e-22	99.80
IUUC-Oga-088057	Otolemur garnettii	75.35	0.00e+00	791.00
IUUC-Oar-089332	Ovis aries	72.55	0.00e+00	758.00
IUUC-Ptr-091551	Pan troglodytes	75.73	0.00e+00	739.00
IUUC-Pan-092173	Papio anubis	78.35	0.00e+00	775.00
IUUC-Psi-093895	Pelodiscus sinensis	71.71	0.00e+00	723.00
IUUC-Pab-097598	Pongo abelii	77.37	0.00e+00	758.00
IUUC-Pva-102135	Pteropus vampyrus	78.45	0.00e+00	783.00
IUUC-Rno-104891	Rattus norvegicus	73.71	0.00e+00	775.00
IUUC-Sha-107192	Sarcophilus harrisii	88.25	0.00e+00	908.00
IUUC-Ssc-115696	Sus scrofa	75.88	0.00e+00	805.00
IUUC-Tgu-117056	Taeniopygia guttata	75.11	0.00e+00	722.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence