iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053774

Ensembl Protein ID

ENSLAFP00000004965.2

UniProt Accession

G3SX55; G3SX55_LOXAF

Protein Name

Uncharacterized protein

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005924.2	ENSLAFT00000005923.2	ENSLAFP00000004965.2
ENSLAFG00000005924.2	ENSLAFT00000036077.1	ENSLAFP00000029199.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.20e-37	125.3	157	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEDGELGFRRGDFIHVM--DNSDPNWWKG--SCHGQTGMFPRNYVTPVN 214
           5689*************************9..9*********..9**************997 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGSDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGCCA TCGCCAAGTA TGACTTCAAA GCTACCGCGG ACGACGAGCT GAGCTTCAAA 60
AGGGGGGACA TCCTCAAGGT AAGTGCCGAG GCACGCTCGG TGCAGAGCTG GCCTCTCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

KEGG

lav:100655474

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	97.92	4.00e-113	399.00
IUUC-Apl-003322	Anas platyrhynchos	95.81	1.00e-110	391.00
IUUC-Aca-005193	Anolis carolinensis	95.85	5.00e-126	442.00
IUUC-Ago-007965	Ashbya gossypii	48.15	8.00e-13	67.00
IUUC-Ame-010929	Astyanax mexicanus	89.86	3.00e-119	420.00
IUUC-Bta-012932	Bos taurus	98.62	1.00e-128	451.00
IUUC-Cel-018665	Caenorhabditis elegans	57.60	3.00e-71	260.00
IUUC-Cja-019225	Callithrix jacchus	98.62	1.00e-128	451.00
IUUC-Cfa-020887	Canis familiaris	98.62	1.00e-128	451.00
IUUC-Cpo-022488	Cavia porcellus	98.62	1.00e-128	451.00
IUUC-Csa-023326	Chlorocebus sabaeus	98.62	1.00e-128	451.00
IUUC-Cho-024953	Choloepus hoffmanni	80.65	1.00e-96	345.00
IUUC-Cin-025144	Ciona intestinalis	64.62	6.00e-75	273.00
IUUC-Csv-026210	Ciona savignyi	60.19	4.00e-71	260.00
IUUC-Dre-028403	Danio rerio	93.55	3.00e-123	433.00
IUUC-Dno-029187	Dasypus novemcinctus	97.24	4.00e-127	446.00
IUUC-Dor-030763	Dipodomys ordii	98.62	1.00e-128	451.00
IUUC-Dme-031741	Drosophila melanogaster	65.09	1.00e-77	282.00
IUUC-Ete-032354	Echinops telfairi	69.44	6.00e-82	296.00
IUUC-Eca-033222	Equus caballus	98.62	1.00e-128	451.00
IUUC-Eeu-034513	Erinaceus europaeus	73.27	4.00e-88	317.00
IUUC-Fca-036294	Felis catus	98.62	1.00e-128	451.00
IUUC-Fal-037130	Ficedula albicollis	95.39	1.00e-124	437.00
IUUC-Gmo-039546	Gadus morhua	92.63	6.00e-122	429.00
IUUC-Gga-041139	Gallus gallus	96.31	3.00e-126	443.00
IUUC-Gac-041968	Gasterosteus aculeatus	93.55	6.00e-123	432.00
IUUC-Ggo-044562	Gorilla gorilla	98.62	1.00e-128	451.00
IUUC-Hsa-046730	Homo sapiens	98.62	1.00e-128	451.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	98.62	1.00e-128	451.00
IUUC-Lch-050230	Latimeria chalumnae	94.03	2.00e-72	265.00
IUUC-Loc-052723	Lepisosteus oculatus	94.47	3.00e-124	437.00
IUUC-Mcc-054603	Macaca mulatta	98.62	1.00e-128	451.00
IUUC-Meu-056173	Macropus eugenii	79.26	1.00e-98	352.00
IUUC-Mga-059950	Meleagris gallopavo	96.31	3.00e-126	443.00
IUUC-Mmr-060878	Microcebus murinus	98.62	1.00e-128	451.00
IUUC-Mdo-062454	Monodelphis domestica	96.31	4.00e-126	442.00
IUUC-Mmu-063913	Mus musculus	98.16	3.00e-128	449.00
IUUC-Mpu-066125	Mustela putorius furo	98.62	1.00e-128	451.00
IUUC-Mlu-068007	Myotis lucifugus	98.62	1.00e-128	451.00
IUUC-Nle-069101	Nomascus leucogenys	98.62	1.00e-128	451.00
IUUC-Opr-071075	Ochotona princeps	98.62	1.00e-128	451.00
IUUC-Ont-072253	Oreochromis niloticus	90.32	3.00e-119	420.00
IUUC-Ocu-074583	Oryctolagus cuniculus	98.62	1.00e-128	451.00
IUUC-Ola-086586	Oryzias latipes	94.23	4.00e-85	307.00
IUUC-Oga-089047	Otolemur garnettii	98.62	1.00e-128	451.00
IUUC-Oar-089904	Ovis aries	91.28	5.00e-117	412.00
IUUC-Ptr-090678	Pan troglodytes	98.62	1.00e-128	451.00
IUUC-Pan-092090	Papio anubis	98.62	1.00e-128	451.00
IUUC-Psi-093765	Pelodiscus sinensis	95.85	1.00e-125	441.00
IUUC-Pma-094650	Petromyzon marinus	84.79	6.00e-111	392.00
IUUC-Pfo-096131	Poecilia formosa	93.09	9.00e-123	432.00
IUUC-Pab-098709	Pongo abelii	98.62	1.00e-128	451.00
IUUC-Pca-100581	Procavia capensis	99.48	1.00e-113	401.00
IUUC-Pva-103066	Pteropus vampyrus	98.62	1.00e-128	451.00
IUUC-Rno-105224	Rattus norvegicus	98.62	1.00e-128	451.00
IUUC-Sce-106302	Saccharomyces cerevisiae	53.70	5.00e-16	77.40
IUUC-Sha-107247	Sarcophilus harrisii	96.34	4.00e-111	393.00
IUUC-Sar-113277	Sorex araneus	82.95	2.00e-102	363.00
IUUC-Ssc-115478	Sus scrofa	98.62	1.00e-128	451.00
IUUC-Tgu-117479	Taeniopygia guttata	94.93	3.00e-124	437.00
IUUC-Tru-118451	Takifugu rubripes	83.84	4.00e-106	376.00
IUUC-Tsy-119029	Tarsius syrichta	93.75	2.00e-83	300.00
IUUC-Tbe-128097	Tupaia belangeri	98.62	3.00e-128	450.00
IUUC-Ttr-128871	Tursiops truncatus	98.72	3.00e-89	319.00
IUUC-Vpa-130754	Vicugna pacos	98.62	1.00e-128	451.00
IUUC-Xtr-132275	Xenopus tropicalis	90.83	2.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence