iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001896

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01011891

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000015087.1	ENSAMET00000016565.1	ENSAMEP00000015904.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.30e-08	34.1	12	74
E3 activity/RING/RING	3.60e-08	33.9	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  CpI l++M +P+ + +G+++  ++I +  ++gg+ cPv+++ +  ++l Pn  l ++++
   Q: 12   EEVTCPICLDPMVEPMSIDCGHSFCHECISEVGKDGGSVCPVCKHNFLLRNLRPNWPLANMVD 74
           6889***************************99**********************88877765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++ + p++ +CgH f+++C+  +      + +   CP+C+
   Q: 16   CPICLDPMVE-PMSIDCGHSFCHECISEV-----GKDGGSVCPVCK 55
           *********9.***************999.....7899999****6 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MASAAPLAMM WEEVTCPICL DPMVEPMSID CGHSFCHECI SEVGKDGGSV CPVCKHNFLL 60
RNLRPNWPLA NMVDNLKQMG QSAKEGTQGE WCKVHGEKLH LFCEEDGKTL CWVCSQSQSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCTCAG CAGCACCCTT GGCAATGATG TGGGAGGAGG TCACGTGCCC TATCTGCCTG 60
GATCCCATGG TGGAGCCTAT GAGCATTGAC TGTGGCCACA GCTTCTGCCA CGAATGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004891	Anolis carolinensis	42.62	8.00e-94	337.00
IUUC-Bta-013083	Bos taurus	74.05	0.00e+00	700.00
IUUC-Cja-019002	Callithrix jacchus	78.21	0.00e+00	748.00
IUUC-Cfa-020415	Canis familiaris	86.75	0.00e+00	850.00
IUUC-Cpo-021948	Cavia porcellus	70.30	0.00e+00	674.00
IUUC-Csa-023135	Chlorocebus sabaeus	79.27	0.00e+00	694.00
IUUC-Cho-024493	Choloepus hoffmanni	67.60	2.00e-99	354.00
IUUC-Dno-030061	Dasypus novemcinctus	71.80	0.00e+00	703.00
IUUC-Ete-033168	Echinops telfairi	68.15	3.00e-168	584.00
IUUC-Eca-033578	Equus caballus	79.10	0.00e+00	759.00
IUUC-Eeu-034749	Erinaceus europaeus	56.99	3.00e-134	471.00
IUUC-Fca-035468	Felis catus	82.45	0.00e+00	796.00
IUUC-Gac-041721	Gasterosteus aculeatus	34.83	1.00e-71	263.00
IUUC-Ggo-045190	Gorilla gorilla	78.42	0.00e+00	720.00
IUUC-Hsa-046583	Homo sapiens	78.85	0.00e+00	723.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	73.83	0.00e+00	681.00
IUUC-Laf-053455	Loxodonta africana	76.23	0.00e+00	689.00
IUUC-Mcc-054609	Macaca mulatta	79.06	0.00e+00	690.00
IUUC-Mmr-061369	Microcebus murinus	74.30	0.00e+00	630.00
IUUC-Mmu-063166	Mus musculus	70.28	0.00e+00	648.00
IUUC-Mpu-066889	Mustela putorius furo	92.09	0.00e+00	904.00
IUUC-Mlu-067647	Myotis lucifugus	79.44	0.00e+00	707.00
IUUC-Nle-069567	Nomascus leucogenys	77.78	0.00e+00	713.00
IUUC-Opr-071178	Ochotona princeps	66.67	3.00e-174	604.00
IUUC-Ont-072675	Oreochromis niloticus	34.14	5.00e-70	258.00
IUUC-Oar-090413	Ovis aries	78.06	0.00e+00	716.00
IUUC-Ptr-091187	Pan troglodytes	78.85	0.00e+00	723.00
IUUC-Pan-092231	Papio anubis	79.06	0.00e+00	692.00
IUUC-Pfo-096972	Poecilia formosa	32.48	9.00e-65	241.00
IUUC-Pab-098079	Pongo abelii	75.35	2.00e-145	508.00
IUUC-Pca-100639	Procavia capensis	74.09	1.00e-149	523.00
IUUC-Pva-102476	Pteropus vampyrus	79.10	0.00e+00	756.00
IUUC-Rno-105054	Rattus norvegicus	69.74	2.00e-167	582.00
IUUC-Sar-113204	Sorex araneus	74.58	0.00e+00	662.00
IUUC-Ssc-116291	Sus scrofa	77.40	0.00e+00	723.00
IUUC-Tsy-118803	Tarsius syrichta	74.47	4.00e-133	468.00
IUUC-Tbe-127337	Tupaia belangeri	61.98	3.00e-107	381.00
IUUC-Ttr-128914	Tursiops truncatus	76.55	0.00e+00	673.00
IUUC-Vpa-130566	Vicugna pacos	75.00	0.00e+00	671.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence