iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036047

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02051995

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000027599.1	ENSFCAT00000025938.1	ENSFCAP00000019706.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.80e-131	436.4	174	506

Active Site

Position(s)	Description	Evidence
475	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 174  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 261
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 262  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 346
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 347  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNVVKWFWKAVEFFDEERRARLLQFV 434
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 435  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 506
           **********************************************************************76 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MSRTHLHTPP DLPEGYEQRT TQQGQVYFLH TQTGVSTWHD PRVPRDLSNI NCEELGPLPP 60
GWEIRNTATG RVYFVDHNNR TTQFTDPRLS ANLHLVLNRQ NQLKDQQQQQ VVSLCPDDAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCAGGA CACATTTACA TACTCCTCCA GACCTACCAG AAGGCTATGG TATGACTAGC 60
AGAGGAAAAA ATAAAGTGTG ATTTACTGAT TTCAGCTTGC TAAGAAAGCC AGAAAATCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-024063	Chlorocebus sabaeus	99.14	0.00e+00	931.00
IUUC-Cho-024804	Choloepus hoffmanni	100.00	0.00e+00	646.00
IUUC-Ggo-044449	Gorilla gorilla	99.24	0.00e+00	824.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	99.21	0.00e+00	1026.00
IUUC-Meu-056436	Macropus eugenii	83.30	0.00e+00	833.00
IUUC-Pca-100516	Procavia capensis	90.41	0.00e+00	637.00
IUUC-Rno-105600	Rattus norvegicus	99.21	0.00e+00	1026.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence