iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054423

UUCD1 version

UUC-LoA-00417

Ensembl Protein ID

ENSLAFP00000010281.4

UniProt Accession

G3T955; G3T955_LOXAF

Protein Name

Uncharacterized protein

Gene Name

EP300

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012289.4	ENSLAFT00000012298.4	ENSLAFP00000010281.4
ENSLAFG00000012289.4	ENSLAFT00000027071.1	ENSLAFP00000028713.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	94.45	0.00e+00	2191.00	IUUC-Hsa-046884

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAENVVEPGP PSAKRPKLSS PALSASASDS TDFGSLFDLE HDLPDELINS TELGLTNGGE 60
ISQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQGMASQPQQ NSPGLGLINS 120

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Nucleotide Sequence
(Fasta)

ATGGCCGAGA ATGTGGTGGA ACCGGGGCCG CCTTCAGCCA AGCGGCCTAA ACTCTCGTCC 60
CCGGCCCTGT CGGCGTCGGC CAGCGACAGC ACAGGTTAGT CTCGGGCCCG GCCTTCCCCG 120

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Sequence Source

Ensembl

Keyword

KW-0012--Acyltransferase
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ

Gene Ontology

GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005667--C:transcription factor complex
GO:0031490--F:chromatin DNA binding
GO:0003684--F:damaged DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0097157--F:pre-mRNA intronic binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0009887--P:animal organ morphogenesis
GO:0030183--P:B cell differentiation
GO:0034644--P:cellular response to UV
GO:0007623--P:circadian rhythm
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0043969--P:histone H2B acetylation
GO:0043967--P:histone H4 acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030324--P:lung development
GO:0010742--P:macrophage derived foam cell differentiation
GO:0035855--P:megakaryocyte development
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030220--P:platelet formation
GO:0043923--P:positive regulation by host of viral transcription
GO:0032092--P:positive regulation of protein binding
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0050821--P:protein stabilization
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0090043--P:regulation of tubulin deacetylation
GO:0043627--P:response to estrogen
GO:0001666--P:response to hypoxia
GO:0007519--P:skeletal muscle tissue development
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002027	Ailuropoda melanoleuca	95.98	0.00e+00	1919.00
IUUC-Aca-005040	Anolis carolinensis	80.53	0.00e+00	1843.00
IUUC-Ame-011395	Astyanax mexicanus	79.72	0.00e+00	1459.00
IUUC-Bta-012649	Bos taurus	93.70	0.00e+00	1995.00
IUUC-Cel-018691	Caenorhabditis elegans	51.13	0.00e+00	845.00
IUUC-Cja-019649	Callithrix jacchus	94.05	0.00e+00	2131.00
IUUC-Cfa-020764	Canis familiaris	97.12	0.00e+00	1796.00
IUUC-Cpo-022345	Cavia porcellus	89.32	0.00e+00	3269.00
IUUC-Cre-022852	Chlamydomonas reinhardtii	35.09	2.00e-65	244.00
IUUC-Csa-023866	Chlorocebus sabaeus	95.67	0.00e+00	2068.00
IUUC-Cho-024951	Choloepus hoffmanni	97.70	0.00e+00	1246.00
IUUC-Csv-026122	Ciona savignyi	65.08	0.00e+00	677.00
IUUC-Ete-032979	Echinops telfairi	91.07	0.00e+00	1778.00
IUUC-Eca-034048	Equus caballus	97.18	0.00e+00	1908.00
IUUC-Fca-035891	Felis catus	96.02	0.00e+00	2043.00
IUUC-Fal-037585	Ficedula albicollis	85.27	0.00e+00	1906.00
IUUC-Gmo-039348	Gadus morhua	87.48	0.00e+00	1446.00
IUUC-Gga-040916	Gallus gallus	85.79	0.00e+00	1921.00
IUUC-Gac-041642	Gasterosteus aculeatus	87.71	0.00e+00	1420.00
IUUC-Ggo-045189	Gorilla gorilla	95.39	0.00e+00	2063.00
IUUC-Hsa-046884	Homo sapiens	95.12	0.00e+00	2062.00
IUUC-Itr-048564	Ictidomys tridecemlineatus	96.60	0.00e+00	1872.00
IUUC-Mcc-054847	Macaca mulatta	95.32	0.00e+00	2072.00
IUUC-Meu-056217	Macropus eugenii	84.49	0.00e+00	1926.00
IUUC-Mga-059250	Meleagris gallopavo	82.18	0.00e+00	1945.00
IUUC-Mmr-061496	Microcebus murinus	96.09	0.00e+00	2078.00
IUUC-Mdo-062478	Monodelphis domestica	84.40	0.00e+00	2055.00
IUUC-Mmu-063456	Mus musculus	95.49	0.00e+00	1901.00
IUUC-Mac-064767	Musa acuminata	39.60	2.00e-75	278.00
IUUC-Mpu-065963	Mustela putorius furo	93.96	0.00e+00	1875.00
IUUC-Mlu-067185	Myotis lucifugus	96.14	0.00e+00	1900.00
IUUC-Ncr-068795	Neurospora crassa	37.97	1.00e-13	71.20
IUUC-Nle-069907	Nomascus leucogenys	95.92	0.00e+00	1870.00
IUUC-Opr-070324	Ochotona princeps	87.41	0.00e+00	1173.00
IUUC-Ont-072211	Oreochromis niloticus	79.98	0.00e+00	1461.00
IUUC-Oan-073723	Ornithorhynchus anatinus	88.96	0.00e+00	1848.00
IUUC-Ocu-074707	Oryctolagus cuniculus	96.22	0.00e+00	1886.00
IUUC-Oba-075590	Oryza barthii	33.66	8.00e-103	369.00
IUUC-Ogu-078580	Oryza glumaepatula	33.52	5.00e-103	369.00
IUUC-Ome-081615	Oryza meridionalis	33.66	9.00e-103	369.00
IUUC-Oni-082636	Oryza nivara	33.66	8.00e-103	369.00
IUUC-Opu-084073	Oryza punctata	33.11	2.00e-99	358.00
IUUC-Oru-084994	Oryza rufipogon	33.66	8.00e-103	369.00
IUUC-Osa-085860	Oryza sativa	41.94	5.00e-62	233.00
IUUC-Olu-087701	Ostreococcus lucimarinus	35.19	7.00e-62	232.00
IUUC-Oga-088700	Otolemur garnettii	94.12	0.00e+00	3432.00
IUUC-Oar-089787	Ovis aries	89.36	0.00e+00	1986.00
IUUC-Ptr-091620	Pan troglodytes	94.43	0.00e+00	2063.00
IUUC-Pan-092166	Papio anubis	94.22	0.00e+00	2091.00
IUUC-Psi-093992	Pelodiscus sinensis	86.86	0.00e+00	1872.00
IUUC-Pma-094328	Petromyzon marinus	85.59	0.00e+00	991.00
IUUC-Ppa-095569	Physcomitrella patens	37.97	8.00e-71	262.00
IUUC-Pfo-097342	Poecilia formosa	84.89	0.00e+00	1382.00
IUUC-Pab-098235	Pongo abelii	94.98	0.00e+00	2062.00
IUUC-Pca-100780	Procavia capensis	89.54	0.00e+00	1469.00
IUUC-Pva-103071	Pteropus vampyrus	96.08	0.00e+00	2199.00
IUUC-Sha-106736	Sarcophilus harrisii	91.74	0.00e+00	1678.00
IUUC-Smo-109420	Selaginella moellendorffii	38.01	4.00e-71	263.00
IUUC-Sar-113162	Sorex araneus	93.42	0.00e+00	839.00
IUUC-Ssc-116077	Sus scrofa	95.53	0.00e+00	2100.00
IUUC-Tgu-116872	Taeniopygia guttata	85.56	0.00e+00	1932.00
IUUC-Tsy-119451	Tarsius syrichta	84.40	0.00e+00	1310.00
IUUC-Tca-121835	Theobroma cacao	39.14	5.00e-73	270.00
IUUC-Tbe-127772	Tupaia belangeri	86.47	0.00e+00	1290.00
IUUC-Ttr-128325	Tursiops truncatus	95.96	0.00e+00	1441.00
IUUC-Vpa-130766	Vicugna pacos	92.31	0.00e+00	1293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence