iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013521

UUCD1 version

UUC-BoT-01093

Ensembl Protein ID

ENSBTAP00000044075.1

UniProt Accession

P23356; Q2NKZ2; UCHL1_BOVIN

Genbank Protein ID

AAI11331.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L1; Neuron cytoplasmic protein 9.5; PGP 9.5; Ubiquitin thioesterase L1

Genbank Nucleotide ID

BC111330

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000005078.5	ENSBTAT00000046823.1	ENSBTAP00000044075.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	8.30e-62	209.6	2	251

Active Site

Position(s)	Description	Evidence
119	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
190	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkine.............................kres 66
           ++ ++e +P+++++++ ++gv +++++e++ +L++e+lg+++ p ++llllF+++                              ++e+
   Q: 2    QLKPMEINPEMLNKVLTRLGVAGQWRFEDVLGLEEESLGSVPAPACALLLLFPLTAqrcfklgreaasrfhhpdypgrlfillvsQHEN 90
           5789************************************************************************************* PP
   S: 67   srksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnsl 154
           +rk+q++    e +++++  +++f+kq+igNsC+t++l+++++n++dkl ++ G+ l++++++t++ spe++a++++++++++++h+++
   Q: 91   FRKKQIE----ELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLeFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDAV 175
           *****99....99**************************************************************************** PP
   S: 155  ariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
           a++++++ +          +k +fhf+++ n++g+lyeldg++pfP+++g ++e+  l+d++kv+r+f+er    e++e+rf+++a+++
   Q: 176  AQEGQCRVD----------DKVNFHFILFNNVDGHLYELDGRMPFPVNHGTSSEDSLLQDAAKVCREFTER----EQGEVRFSAVALCK 250
           *******99..........5679************************************************....************98 PP
   S: 244  d 244
           +
   Q: 251  A 251
           7 PP

Organism

Bos taurus

Functional Description
(View)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLTRL GVAGQWRFED VLGLEEESLG SVPAPACALL LLFPLTAQRC 60
FKLGREAASR FHHPDYPGRL FILLVSQHEN FRKKQIEELK GQEVSPKVYF MKQTIGNSCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTTTTTT CGCTTCTCTG GGTTGTGTTC GTTTCGACGT CCGCGAAGAT GCAGCTCAAA 60
CCAATGGAGA TTAACCCCGA GGTGAGCGTC AGGTGCATGG TTGCCCGGGG GTGGCGGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0436--Ligase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0636--Prenylation
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:514394

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	91.41	4.00e-124	436.00
IUUC-Apl-003693	Anas platyrhynchos	62.06	7.00e-88	316.00
IUUC-Aca-004716	Anolis carolinensis	67.19	4.00e-96	343.00
IUUC-Ame-011806	Astyanax mexicanus	58.73	3.00e-79	287.00
IUUC-Cja-018752	Callithrix jacchus	86.17	5.00e-113	399.00
IUUC-Cfa-020442	Canis familiaris	86.56	1.00e-113	402.00
IUUC-Cpo-021723	Cavia porcellus	98.80	1.00e-95	342.00
IUUC-Csa-023626	Chlorocebus sabaeus	85.71	6.00e-113	399.00
IUUC-Cho-024548	Choloepus hoffmanni	67.15	1.00e-35	142.00
IUUC-Dre-027854	Danio rerio	57.71	4.00e-79	286.00
IUUC-Dno-029325	Dasypus novemcinctus	85.71	3.00e-114	403.00
IUUC-Dor-030114	Dipodomys ordii	83.73	2.00e-121	427.00
IUUC-Ete-033092	Echinops telfairi	96.36	9.00e-93	332.00
IUUC-Eca-033854	Equus caballus	99.30	5.00e-81	292.00
IUUC-Eeu-034493	Erinaceus europaeus	83.73	1.00e-109	389.00
IUUC-Fal-036693	Ficedula albicollis	64.85	4.00e-87	313.00
IUUC-Gmo-038848	Gadus morhua	53.94	3.00e-70	257.00
IUUC-Gga-041078	Gallus gallus	66.01	4.00e-96	343.00
IUUC-Gac-042064	Gasterosteus aculeatus	54.62	3.00e-73	267.00
IUUC-Ggo-044827	Gorilla gorilla	85.71	2.00e-113	400.00
IUUC-Hsa-045820	Homo sapiens	85.71	2.00e-113	400.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	86.11	5.00e-114	403.00
IUUC-Lch-050121	Latimeria chalumnae	64.94	1.00e-92	332.00
IUUC-Loc-052342	Lepisosteus oculatus	61.57	7.00e-87	313.00
IUUC-Laf-053916	Loxodonta africana	84.25	1.00e-111	395.00
IUUC-Mcc-054838	Macaca mulatta	85.71	6.00e-113	399.00
IUUC-Meu-056478	Macropus eugenii	79.37	3.00e-116	410.00
IUUC-Mga-059878	Meleagris gallopavo	64.63	4.00e-90	323.00
IUUC-Mdo-062544	Monodelphis domestica	78.17	7.00e-105	372.00
IUUC-Mmu-063300	Mus musculus	85.71	2.00e-123	434.00
IUUC-Mpu-066128	Mustela putorius furo	84.28	2.00e-99	355.00
IUUC-Mlu-067778	Myotis lucifugus	84.92	4.00e-122	430.00
IUUC-Nle-069686	Nomascus leucogenys	86.11	8.00e-114	402.00
IUUC-Opr-070535	Ochotona princeps	96.97	2.00e-94	338.00
IUUC-Ont-071510	Oreochromis niloticus	54.98	2.00e-74	271.00
IUUC-Ocu-074590	Oryctolagus cuniculus	84.92	2.00e-113	400.00
IUUC-Oga-089013	Otolemur garnettii	91.27	4.00e-126	443.00
IUUC-Oar-089861	Ovis aries	98.81	3.00e-138	483.00
IUUC-Ptr-091536	Pan troglodytes	84.13	5.00e-111	393.00
IUUC-Pan-092909	Papio anubis	85.71	6.00e-113	399.00
IUUC-Psi-093818	Pelodiscus sinensis	69.96	2.00e-98	351.00
IUUC-Pfo-097335	Poecilia formosa	51.57	2.00e-72	264.00
IUUC-Pab-098048	Pongo abelii	85.71	2.00e-113	400.00
IUUC-Pca-100818	Procavia capensis	64.29	5.00e-63	233.00
IUUC-Pva-102954	Pteropus vampyrus	84.52	1.00e-108	385.00
IUUC-Rno-105966	Rattus norvegicus	85.71	2.00e-123	434.00
IUUC-Sha-107111	Sarcophilus harrisii	87.88	2.00e-87	313.00
IUUC-Sar-113190	Sorex araneus	76.32	1.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	71.65	2.00e-96	344.00
IUUC-Tgu-117465	Taeniopygia guttata	61.25	1.00e-80	292.00
IUUC-Tru-118565	Takifugu rubripes	52.79	2.00e-64	238.00
IUUC-Tsy-119561	Tarsius syrichta	96.36	1.00e-92	332.00
IUUC-Tbe-128048	Tupaia belangeri	96.36	2.00e-93	334.00
IUUC-Ttr-128494	Tursiops truncatus	85.66	1.00e-111	394.00
IUUC-Xtr-132286	Xenopus tropicalis	60.71	9.00e-86	309.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence