iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023736

Ensembl Protein ID

ENSCSAP00000010372.1

UniProt Accession

A0A0D9RP33; A0A0D9RP33_CHLSB

Genbank Protein ID

ENSCSAP00000010372

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AC238859

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000014236.1	ENSCSAT00000012331.1	ENSCSAP00000010372.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	98.36	0.00e+00	924.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MLLHPPPQLS PFLQPHGQQV PYYLENEPSG YTVREAGPPA FYRPNSDNRR QGGRERLAST 60
NDKGSMAMES AKETRYCAVC NDYASGYHYG VWSCEGCKAF FKRSIQGHND YMCPATNQCT 120

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Nucleotide Sequence
(Fasta)

GTCTACGGCC AGACGGGCCT CCCGTACGGC CCCGGGTCTG AGGCTGCGGC GTTCGGCTCC 60
AACGGCCTGG GGGGTTTCCC CCCACTCAAC AGCGTGTCTC CGAGCCCGCT GATGCTGCTG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	94.21	0.00e+00	808.00
IUUC-Apl-003688	Anas platyrhynchos	85.35	0.00e+00	693.00
IUUC-Aca-005222	Anolis carolinensis	81.74	0.00e+00	754.00
IUUC-Ame-010731	Astyanax mexicanus	58.21	1.00e-134	473.00
IUUC-Bta-013112	Bos taurus	91.10	0.00e+00	830.00
IUUC-Cja-019408	Callithrix jacchus	97.48	0.00e+00	900.00
IUUC-Cfa-020694	Canis familiaris	93.07	0.00e+00	865.00
IUUC-Cpo-021426	Cavia porcellus	86.76	0.00e+00	803.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.20e+00	26.60
IUUC-Dre-027698	Danio rerio	57.39	1.00e-131	463.00
IUUC-Dno-029477	Dasypus novemcinctus	90.87	0.00e+00	772.00
IUUC-Dor-030572	Dipodomys ordii	89.86	0.00e+00	744.00
IUUC-Ete-032849	Echinops telfairi	82.43	0.00e+00	634.00
IUUC-Eca-033605	Equus caballus	88.91	0.00e+00	817.00
IUUC-Eeu-034683	Erinaceus europaeus	72.17	5.00e-159	553.00
IUUC-Fca-035928	Felis catus	93.29	0.00e+00	798.00
IUUC-Fal-036754	Ficedula albicollis	83.16	0.00e+00	777.00
IUUC-Gmo-038872	Gadus morhua	55.99	6.00e-112	397.00
IUUC-Gga-040988	Gallus gallus	83.78	0.00e+00	766.00
IUUC-Gac-042015	Gasterosteus aculeatus	63.17	4.00e-126	444.00
IUUC-Ggo-044749	Gorilla gorilla	98.95	0.00e+00	910.00
IUUC-Hsa-046944	Homo sapiens	98.32	0.00e+00	902.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	92.81	0.00e+00	843.00
IUUC-Loc-052414	Lepisosteus oculatus	65.63	5.00e-171	594.00
IUUC-Mcc-054781	Macaca mulatta	99.58	0.00e+00	914.00
IUUC-Meu-056232	Macropus eugenii	90.00	0.00e+00	818.00
IUUC-Mga-059319	Meleagris gallopavo	84.41	0.00e+00	771.00
IUUC-Mmr-061636	Microcebus murinus	94.38	1.00e-133	469.00
IUUC-Mdo-062661	Monodelphis domestica	90.34	0.00e+00	823.00
IUUC-Mmu-063330	Mus musculus	91.39	0.00e+00	816.00
IUUC-Mpu-065757	Mustela putorius furo	93.31	0.00e+00	864.00
IUUC-Mlu-067712	Myotis lucifugus	92.86	0.00e+00	853.00
IUUC-Nle-069283	Nomascus leucogenys	99.37	0.00e+00	912.00
IUUC-Opr-070391	Ochotona princeps	90.04	0.00e+00	868.00
IUUC-Ont-071369	Oreochromis niloticus	57.24	6.00e-118	417.00
IUUC-Oan-073734	Ornithorhynchus anatinus	74.34	3.00e-133	467.00
IUUC-Ocu-074292	Oryctolagus cuniculus	92.23	0.00e+00	851.00
IUUC-Oba-075103	Oryza barthii	28.21	1.00e-02	35.00
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.40
IUUC-Olo-080944	Oryza longistaminata	28.21	4.00e-03	34.30
IUUC-Oni-082560	Oryza nivara	28.21	8.00e-03	35.00
IUUC-Ola-087052	Oryzias latipes	52.71	1.00e-123	437.00
IUUC-Oga-088586	Otolemur garnettii	92.28	0.00e+00	851.00
IUUC-Oar-090156	Ovis aries	91.95	0.00e+00	825.00
IUUC-Ptr-091321	Pan troglodytes	99.16	0.00e+00	910.00
IUUC-Pan-092851	Papio anubis	99.58	0.00e+00	913.00
IUUC-Psi-093434	Pelodiscus sinensis	82.96	0.00e+00	818.00
IUUC-Pfo-097379	Poecilia formosa	56.71	1.00e-130	459.00
IUUC-Pab-097735	Pongo abelii	99.16	0.00e+00	910.00
IUUC-Pva-102125	Pteropus vampyrus	89.92	0.00e+00	827.00
IUUC-Rno-106121	Rattus norvegicus	90.97	0.00e+00	811.00
IUUC-Sha-107547	Sarcophilus harrisii	90.34	0.00e+00	819.00
IUUC-Sar-113650	Sorex araneus	85.81	2.00e-147	515.00
IUUC-Tgu-117175	Taeniopygia guttata	83.78	0.00e+00	783.00
IUUC-Tru-117545	Takifugu rubripes	55.48	3.00e-133	469.00
IUUC-Tsy-119586	Tarsius syrichta	81.93	0.00e+00	773.00
IUUC-Tni-120121	Tetraodon nigroviridis	56.82	4.00e-135	475.00
IUUC-Tbe-127548	Tupaia belangeri	82.21	0.00e+00	644.00
IUUC-Ttr-128374	Tursiops truncatus	86.76	0.00e+00	784.00
IUUC-Vpa-130464	Vicugna pacos	82.51	5.00e-156	543.00
IUUC-Xtr-132171	Xenopus tropicalis	75.05	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence