iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000019358.7	ENSRNOT00000082133.1	ENSRNOP00000071981.1
ENSRNOG00000019358.7	ENSRNOT00000026350.7	ENSRNOP00000026350.7
ENSRNOG00000019358.7	ENSRNOT00000078494.1	ENSRNOP00000071400.1
ENSRNOG00000019358.7	ENSRNOT00000088168.1	ENSRNOP00000071034.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	88.67	0.00e+00	936.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPA VFNYPEGAAY 60
EFNAAAAAAA AGASAPVYGQ SSITYGPGSE AAAFGANSLG AFPQLNSVSP SPLMLLHPPP 120

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Nucleotide Sequence
(Fasta)

GACGCCAGGA GAGGCCAATG CCCCCTCCTC TGCCATTGTC TAGCCTAAGA AGGCAGTCTC 60
TGGGCGACAT TCTTCTAAAG CAGGTACTTC TATTTATCTC CATTTCTTTA CAATTTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	91.54	0.00e+00	761.00
IUUC-Apl-003688	Anas platyrhynchos	78.82	0.00e+00	801.00
IUUC-Aca-005222	Anolis carolinensis	76.97	0.00e+00	860.00
IUUC-Ame-010731	Astyanax mexicanus	56.49	4.00e-136	478.00
IUUC-Bta-013112	Bos taurus	86.02	0.00e+00	883.00
IUUC-Cja-019408	Callithrix jacchus	89.50	0.00e+00	957.00
IUUC-Cfa-020694	Canis familiaris	86.86	0.00e+00	907.00
IUUC-Cpo-021426	Cavia porcellus	86.36	0.00e+00	912.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.30e+00	26.60
IUUC-Csa-023736	Chlorocebus sabaeus	91.17	0.00e+00	843.00
IUUC-Dre-027698	Danio rerio	57.02	2.00e-134	472.00
IUUC-Dno-029477	Dasypus novemcinctus	89.38	0.00e+00	746.00
IUUC-Dor-030572	Dipodomys ordii	93.00	0.00e+00	758.00
IUUC-Ete-032849	Echinops telfairi	68.54	0.00e+00	629.00
IUUC-Eca-033605	Equus caballus	84.17	0.00e+00	902.00
IUUC-Eeu-034683	Erinaceus europaeus	90.14	1.00e-105	376.00
IUUC-Fca-035928	Felis catus	91.50	0.00e+00	758.00
IUUC-Fal-036754	Ficedula albicollis	76.21	0.00e+00	865.00
IUUC-Gmo-038872	Gadus morhua	56.05	8.00e-112	397.00
IUUC-Gga-040988	Gallus gallus	77.04	0.00e+00	858.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.76	3.00e-125	442.00
IUUC-Ggo-044749	Gorilla gorilla	89.67	0.00e+00	957.00
IUUC-Hsa-046944	Homo sapiens	88.67	0.00e+00	946.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	91.36	0.00e+00	971.00
IUUC-Loc-052414	Lepisosteus oculatus	58.52	0.00e+00	637.00
IUUC-Mcc-054781	Macaca mulatta	89.33	0.00e+00	955.00
IUUC-Meu-056232	Macropus eugenii	82.50	0.00e+00	882.00
IUUC-Mga-059319	Meleagris gallopavo	77.20	0.00e+00	860.00
IUUC-Mmr-061636	Microcebus murinus	87.06	1.00e-164	572.00
IUUC-Mdo-062661	Monodelphis domestica	83.17	0.00e+00	890.00
IUUC-Mmu-063330	Mus musculus	97.67	0.00e+00	1024.00
IUUC-Mpu-065757	Mustela putorius furo	88.87	0.00e+00	926.00
IUUC-Mlu-067712	Myotis lucifugus	88.45	0.00e+00	826.00
IUUC-Nle-069283	Nomascus leucogenys	89.33	0.00e+00	920.00
IUUC-Opr-070391	Ochotona princeps	88.13	0.00e+00	963.00
IUUC-Ont-071369	Oreochromis niloticus	55.97	2.00e-120	426.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.30	1.00e-125	442.00
IUUC-Ocu-074292	Oryctolagus cuniculus	90.83	0.00e+00	957.00
IUUC-Oba-075103	Oryza barthii	29.11	1.00e-03	38.10
IUUC-Ogu-079042	Oryza glumaepatula	29.11	2.00e-04	40.40
IUUC-Olo-080944	Oryza longistaminata	29.11	4.00e-04	37.70
IUUC-Oni-082560	Oryza nivara	29.11	9.00e-04	38.50
IUUC-Ola-087052	Oryzias latipes	54.77	3.00e-128	452.00
IUUC-Oga-088586	Otolemur garnettii	89.22	0.00e+00	946.00
IUUC-Oar-090156	Ovis aries	89.71	0.00e+00	784.00
IUUC-Ptr-091321	Pan troglodytes	89.50	0.00e+00	956.00
IUUC-Pan-092851	Papio anubis	89.17	0.00e+00	953.00
IUUC-Psi-093434	Pelodiscus sinensis	76.17	0.00e+00	887.00
IUUC-Pfo-097379	Poecilia formosa	58.19	1.00e-134	473.00
IUUC-Pab-097735	Pongo abelii	89.33	0.00e+00	954.00
IUUC-Pva-102125	Pteropus vampyrus	85.83	0.00e+00	905.00
IUUC-Sha-107547	Sarcophilus harrisii	83.50	0.00e+00	889.00
IUUC-Sar-113650	Sorex araneus	77.67	1.00e-174	605.00
IUUC-Tgu-117175	Taeniopygia guttata	76.87	0.00e+00	872.00
IUUC-Tru-117545	Takifugu rubripes	54.47	7.00e-134	471.00
IUUC-Tsy-119586	Tarsius syrichta	74.88	0.00e+00	785.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.64	1.00e-135	476.00
IUUC-Tbe-127548	Tupaia belangeri	81.49	2.00e-179	622.00
IUUC-Ttr-128374	Tursiops truncatus	83.67	0.00e+00	823.00
IUUC-Vpa-130464	Vicugna pacos	81.10	2.00e-151	528.00
IUUC-Xtr-132171	Xenopus tropicalis	68.33	0.00e+00	711.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence