iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000172725.13	ENST00000616321.4	ENSP00000479949.1
ENSG00000172725.13	ENST00000341356.9	ENSP00000340211.5
ENSG00000172725.13	ENST00000537042.5	ENSP00000445330.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-16	60.8	80	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gHt++v ++++   +d  ++sGs D+t++vW +
   Q: 80   GHTGPVLDIDWcphNDEVIASGSEDCTVMVWQI 112
           8***********977799*************75 PP

Organism

Homo sapiens

Functional Description
(View)

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Protein Sequence
(Fasta)

MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF 60
LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMVW QIPENGLTSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCAATCCT GGAGACTCCT GCGGATGCCA TTATGAGGAG CAAGAACGCG AAGGGGCCTC 60
GGGTCCGCTG TAAGGCTGCA CCCGCACCTG CGGCGCCTCT GCGGCGGCCG CCGTCGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0031252--C:cell leading edge
GO:0071944--C:cell periphery
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001725--C:stress fiber
GO:0051015--F:actin filament binding
GO:0071933--F:Arp2/3 complex binding
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0030036--P:actin cytoskeleton organization
GO:0090135--P:actin filament branching
GO:0051017--P:actin filament bundle assembly
GO:0016477--P:cell migration
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0035767--P:endothelial cell chemotaxis
GO:0034316--P:negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0071672--P:negative regulation of smooth muscle cell chemotaxis
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:1902463--P:protein localization to cell leading edge
GO:0034315--P:regulation of Arp2/3 complex-mediated actin nucleation
GO:0031529--P:ruffle organization
GO:0042060--P:wound healing

KEGG

hsa:57175

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002423	Ailuropoda melanoleuca	93.87	0.00e+00	941.00
IUUC-Aca-005056	Anolis carolinensis	80.82	0.00e+00	809.00
IUUC-Bta-012984	Bos taurus	91.99	0.00e+00	927.00
IUUC-Cja-019498	Callithrix jacchus	97.96	0.00e+00	954.00
IUUC-Cfa-020937	Canis familiaris	96.96	0.00e+00	869.00
IUUC-Cpo-021866	Cavia porcellus	89.78	0.00e+00	897.00
IUUC-Csa-023561	Chlorocebus sabaeus	97.75	0.00e+00	961.00
IUUC-Dno-029770	Dasypus novemcinctus	86.97	0.00e+00	868.00
IUUC-Dor-030989	Dipodomys ordii	91.62	0.00e+00	905.00
IUUC-Eca-033901	Equus caballus	94.48	0.00e+00	931.00
IUUC-Fca-036494	Felis catus	93.87	0.00e+00	910.00
IUUC-Fal-036737	Ficedula albicollis	82.65	0.00e+00	834.00
IUUC-Ggo-045035	Gorilla gorilla	99.39	0.00e+00	972.00
IUUC-Itr-048847	Ictidomys tridecemlineatus	93.66	0.00e+00	907.00
IUUC-Laf-054566	Loxodonta africana	92.02	0.00e+00	894.00
IUUC-Mcc-054879	Macaca mulatta	97.96	0.00e+00	961.00
IUUC-Mmr-060910	Microcebus murinus	92.64	0.00e+00	924.00
IUUC-Mmu-063455	Mus musculus	94.07	0.00e+00	936.00
IUUC-Mpu-066350	Mustela putorius furo	93.46	0.00e+00	922.00
IUUC-Mlu-067353	Myotis lucifugus	93.62	0.00e+00	927.00
IUUC-Nle-069161	Nomascus leucogenys	99.18	0.00e+00	966.00
IUUC-Opr-071106	Ochotona princeps	91.41	0.00e+00	899.00
IUUC-Oga-088805	Otolemur garnettii	93.46	0.00e+00	933.00
IUUC-Ptr-091484	Pan troglodytes	99.59	0.00e+00	975.00
IUUC-Pan-091843	Papio anubis	97.55	0.00e+00	952.00
IUUC-Pab-097835	Pongo abelii	99.18	0.00e+00	969.00
IUUC-Pca-100411	Procavia capensis	81.80	0.00e+00	791.00
IUUC-Pva-102659	Pteropus vampyrus	94.27	0.00e+00	934.00
IUUC-Rno-106070	Rattus norvegicus	93.25	0.00e+00	928.00
IUUC-Sha-106609	Sarcophilus harrisii	94.08	0.00e+00	715.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence