iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068903

Ensembl Protein ID

ESA43585

UniProt Accession

V5IPD6; V5IPD6_NEUCR

Genbank Protein ID

ESA43585.1

Protein Name

Ubiquitin-protein ligase

Genbank Nucleotide ID

CM002237

Gene Name

NCU06756

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU06756	ESA43585	ESA43585
NCU06756	ESA43584	ESA43584

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-82	275.2	987	1330

Active Site

Position(s)	Description	Evidence
1299	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           +d+kk l+++f+gEeg+d+gG+ +e++ ll++e++npd g+f+y+e+++++ + np+s       +++F ++G++ g+a++++ +ld+ l+++ +++ll
   Q: 987  EDIKKGLKINFKGEEGIDAGGLRKEWFLLLVREVFNPDHGMFVYDEDSQYC-YFNPASLE---PSEQYF-LVGVVFGLAIYNSTILDVALPPFAFRKLL 1080
           6899******************************************99998.66999984...456777.99***********************9998 PP
   S: 102  gk...............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkeg 185
                             +sl+dl+e  p l+  l +++e+ + d+e + ++l f v+ e +g+t+ + L+p+Ge+ pVtn+N++eYv+l+v y l + 
   Q: 1081 MAappptlatsqprqpmTYSLDDLAEYRPRLASGLRQLLEY-DGDVEST-FCLDFVVDIERYGSTERVSLCPNGERRPVTNANRREYVDLYVRYLLDTA 1177
           887777777777776666999********************.6788886.************************************************* PP
   S: 186  ikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky....kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGf 279
           +++q+e f++Gf++v+  + lslF++ee+ell+ G+ e++d+++lk+ ++y    +++  e++p++ wFwe +ee s  +++++L F+Tgs+r+P+gG 
   Q: 1178 VTRQFEPFKRGFYTVCGGNALSLFRPEEIELLVRGSdESLDISALKSAATYdnwsTKNPVETEPTVGWFWELFEEASPADQRKLLLFITGSDRIPAGGA 1276
           ************************************9**************777755677899************************************ PP
   S: 280  aelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           a+l+ r+ ++ +  +  r+P++ TCfn L L++Y s e lke L +A+ e++gF+l
   Q: 1277 AALSIRIACLGE--DCGRYPTARTCFNSLALWKYGSRERLKEVLWTAVLESEGFGL 1330
           ****88777766..56**************************************98 PP

Organism

Neurospora crassa

Protein Sequence
(Fasta)

MAIYTPQARS TREGTMNIND TSTPPSMAVS TTSPFWPLGP FPNRVDSHAN SHPLPHQLQH 60
PPQDPLQHPQ APFSQGSSQR QQQQQHPQWH PHPFPQSHRA FGPPPSAGSI ITTNNLNRKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCATCT ATACCCCCCA GGCACGGTCT ACGCGAGAAG GTACCATGAA TATCAACGAC 60
ACCTCCACGC CTCCTTCGAT GGCGGTCTCG ACCACTTCGC CCTTTTGGCC ATTGGGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ncr:NCU06756

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	38.84	4.00e-99	353.00
IUUC-Atr-003144	Amborella trichopoda	40.04	1.00e-87	315.00
IUUC-Apl-003589	Anas platyrhynchos	38.72	4.00e-92	330.00
IUUC-Aca-004350	Anolis carolinensis	40.57	6.00e-97	346.00
IUUC-Ago-007908	Ashbya gossypii	31.66	4.00e-94	337.00
IUUC-Acl-008288	Aspergillus clavatus	44.79	0.00e+00	895.00
IUUC-Afl-008402	Aspergillus flavus	55.67	0.00e+00	716.00
IUUC-Afu-008762	Aspergillus fumigatus	44.72	0.00e+00	912.00
IUUC-Ani-009176	Aspergillus nidulans	43.58	0.00e+00	808.00
IUUC-Ang-009791	Aspergillus niger	45.09	0.00e+00	850.00
IUUC-Aor-009921	Aspergillus oryzae	60.80	0.00e+00	699.00
IUUC-Ate-010295	Aspergillus terreus	52.38	0.00e+00	850.00
IUUC-Ame-010768	Astyanax mexicanus	36.99	6.00e-83	300.00
IUUC-Bgr-011981	Blumeria graminis	47.64	0.00e+00	998.00
IUUC-Bta-012945	Bos taurus	40.79	7.00e-98	349.00
IUUC-Bci-013697	Botrytis cinerea	47.83	0.00e+00	919.00
IUUC-Cel-018150	Caenorhabditis elegans	33.10	1.00e-53	203.00
IUUC-Cja-019263	Callithrix jacchus	39.91	4.00e-96	343.00
IUUC-Cfa-020486	Canis familiaris	39.04	2.00e-98	351.00
IUUC-Cpo-021755	Cavia porcellus	38.65	4.00e-98	350.00
IUUC-Cre-022740	Chlamydomonas reinhardtii	41.52	2.00e-63	234.00
IUUC-Csa-023814	Chlorocebus sabaeus	39.85	7.00e-87	313.00
IUUC-Cho-025059	Choloepus hoffmanni	36.79	4.00e-69	254.00
IUUC-Cin-025643	Ciona intestinalis	37.96	2.00e-70	258.00
IUUC-Csv-026282	Ciona savignyi	38.19	1.00e-64	239.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	54.01	0.00e+00	1059.00
IUUC-Cme-027151	Cyanidioschyzon merolae	38.28	2.00e-79	289.00
IUUC-Dre-028551	Danio rerio	40.71	2.00e-95	341.00
IUUC-Dno-029497	Dasypus novemcinctus	40.13	1.00e-95	342.00
IUUC-Dor-030756	Dipodomys ordii	42.32	7.00e-72	263.00
IUUC-Dse-031239	Dothistroma septosporum	40.19	0.00e+00	827.00
IUUC-Dme-032103	Drosophila melanogaster	35.40	6.00e-69	254.00
IUUC-Ete-032902	Echinops telfairi	36.25	1.00e-88	319.00
IUUC-Eca-033678	Equus caballus	39.04	2.00e-98	351.00
IUUC-Eeu-035109	Erinaceus europaeus	37.83	3.00e-71	261.00
IUUC-Fca-035590	Felis catus	38.84	4.00e-99	353.00
IUUC-Fal-037123	Ficedula albicollis	37.03	1.00e-83	302.00
IUUC-Fox-037941	Fusarium oxysporum	52.74	0.00e+00	1102.00
IUUC-Fso-038388	Fusarium solani	53.24	0.00e+00	1099.00
IUUC-Gmo-039553	Gadus morhua	40.75	5.00e-86	310.00
IUUC-Ggr-040110	Gaeumannomyces graminis	53.81	0.00e+00	1128.00
IUUC-Gga-040406	Gallus gallus	39.12	2.00e-96	345.00
IUUC-Gac-042141	Gasterosteus aculeatus	38.84	5.00e-94	336.00
IUUC-Ggo-045504	Gorilla gorilla	39.69	7.00e-96	343.00
IUUC-Hsa-045786	Homo sapiens	39.69	5.00e-96	343.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	39.48	7.00e-79	286.00
IUUC-Kpa-049152	Komagataella pastoris	36.01	9.00e-92	329.00
IUUC-Lch-049824	Latimeria chalumnae	41.56	1.00e-84	305.00
IUUC-Loc-052173	Lepisosteus oculatus	39.04	3.00e-98	351.00
IUUC-Laf-054017	Loxodonta africana	40.13	4.00e-96	343.00
IUUC-Mcc-055713	Macaca mulatta	39.91	5.00e-96	343.00
IUUC-Meu-056061	Macropus eugenii	39.24	2.00e-78	285.00
IUUC-Mor-057045	Magnaporthe oryzae	53.55	0.00e+00	1139.00
IUUC-Mla-059187	Melampsora laricipopulina	42.89	2.00e-92	331.00
IUUC-Mga-059884	Meleagris gallopavo	41.27	3.00e-90	324.00
IUUC-Mmr-061344	Microcebus murinus	39.24	5.00e-100	357.00
IUUC-Mdo-062653	Monodelphis domestica	41.23	1.00e-97	349.00
IUUC-Mmu-063775	Mus musculus	41.28	2.00e-98	352.00
IUUC-Mpu-066069	Mustela putorius furo	39.04	1.00e-98	352.00
IUUC-Mlu-067925	Myotis lucifugus	41.01	5.00e-99	353.00
IUUC-Nfi-068439	Neosartorya fischeri	50.95	0.00e+00	852.00
IUUC-Nle-070046	Nomascus leucogenys	37.65	3.00e-96	344.00
IUUC-Opr-070570	Ochotona princeps	34.28	1.00e-59	222.00
IUUC-Ont-072126	Oreochromis niloticus	39.24	1.00e-96	345.00
IUUC-Oan-072933	Ornithorhynchus anatinus	40.97	8.00e-97	345.00
IUUC-Ocu-073800	Oryctolagus cuniculus	40.57	2.00e-96	344.00
IUUC-Ola-086988	Oryzias latipes	40.48	2.00e-93	335.00
IUUC-Oga-088117	Otolemur garnettii	40.79	9.00e-97	345.00
IUUC-Oar-089371	Ovis aries	40.79	1.00e-97	348.00
IUUC-Ptr-090551	Pan troglodytes	39.69	5.00e-96	343.00
IUUC-Pan-092067	Papio anubis	39.91	5.00e-96	343.00
IUUC-Psi-092963	Pelodiscus sinensis	39.47	2.00e-93	335.00
IUUC-Pma-094643	Petromyzon marinus	38.56	2.00e-82	298.00
IUUC-Ppa-095354	Physcomitrella patens	40.71	5.00e-92	330.00
IUUC-Pfo-096562	Poecilia formosa	38.14	2.00e-93	334.00
IUUC-Pab-098680	Pongo abelii	39.69	4.00e-96	343.00
IUUC-Pca-100869	Procavia capensis	38.68	2.00e-77	281.00
IUUC-Pva-103040	Pteropus vampyrus	42.32	3.00e-70	258.00
IUUC-Pgr-103315	Puccinia graminis	36.88	3.00e-100	358.00
IUUC-Ptt-103736	Puccinia triticina	44.21	3.00e-101	361.00
IUUC-Rno-105270	Rattus norvegicus	41.01	1.00e-98	352.00
IUUC-Sce-106306	Saccharomyces cerevisiae	31.30	2.00e-79	288.00
IUUC-Sha-106819	Sarcophilus harrisii	31.51	1.00e-101	362.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	40.06	3.00e-63	234.00
IUUC-Spo-108271	Schizosaccharomyces pombe	37.82	2.00e-115	408.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	47.81	0.00e+00	949.00
IUUC-Smo-108858	Selaginella moellendorffii	41.82	2.00e-88	318.00
IUUC-Sar-113134	Sorex araneus	37.09	2.00e-82	298.00
IUUC-Ssc-115441	Sus scrofa	40.70	1.00e-97	348.00
IUUC-Tgu-117166	Taeniopygia guttata	39.12	2.00e-92	332.00
IUUC-Tru-118368	Takifugu rubripes	39.01	5.00e-82	297.00
IUUC-Tsy-118898	Tarsius syrichta	35.43	2.00e-77	281.00
IUUC-Tni-120233	Tetraodon nigroviridis	36.85	8.00e-74	270.00
IUUC-Tre-122108	Trichoderma reesei	50.78	0.00e+00	1013.00
IUUC-Tvi-122644	Trichoderma virens	50.77	0.00e+00	1037.00
IUUC-Tme-127004	Tuber melanosporum	48.28	0.00e+00	791.00
IUUC-Tbe-127292	Tupaia belangeri	33.78	1.00e-68	252.00
IUUC-Ttr-128352	Tursiops truncatus	38.55	3.00e-87	314.00
IUUC-Vda-129969	Verticillium dahliae	52.98	0.00e+00	1060.00
IUUC-Vpa-130448	Vicugna pacos	34.81	3.00e-71	261.00
IUUC-Xtr-132594	Xenopus tropicalis	38.94	2.00e-84	305.00
IUUC-Xma-134157	Xiphophorus maculatus	40.44	4.00e-84	303.00
IUUC-Yli-134470	Yarrowia lipolytica	38.97	8.00e-100	356.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence