iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069978

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01030585

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000009683.2	ENSNLET00000012408.2	ENSNLEP00000011826.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-88	297.4	695	1014

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            d+ k+l vef +E + + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F ++G+l+g++l++ ++ +
   Q: 695  TDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKL----EKKRYF-LFGMLCGLSLFNLNVAN 776
           688899**************************************************998....677888.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ ++yk+ll++k sledl+e+ p + ksl+e+++ + +di ++ l++ fs+      ++++++L+p+G +ipV ++Nk++Yv++
   Q: 777  LPFPLALYKKLLDQKPSLEDLKELSPRVGKSLQEVLNDDADDIGDA-LCIHFSI----HWDQNDVDLIPDGISIPVDQTNKKDYVSR 858
           ************************************9999999997.9999985....55789999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y+++ ++ke +e+f++Gf++v+++e+l+ F ++el + i G++++d+++++++ ky++gy++++p+iq Fw+++++++ +e+k+
   Q: 859  YIDYIFNVSVKEVYEEFQRGFYRVCEKEILRHFYPKELMTAIIGNTDYDWKHFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKK 945
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++++  +f +++  s+++  +s TC + L LP+Ys++e ++e L++Ai++++gF
   Q: 946  FLFFLTGRDRLHARGIQKME-IVFRCPETFSERDHLTSITCHYILYLPKYSTMERMEEALQVAINNNRGF 1014
           ********************.778888889999999*********************************9 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MYFCWGADSR ELQRRRTEGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA 60
PRGELPEPIQ ALETLNVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG ELKEISFTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACCGCTTG AACCCGTGAG GCGGAGGTTG CAGTGAGCCG AGATGGTGCC ACTGCACTTC 60
AGCCTGGGCA ACAGAGCGAG ACTCCGTCTC AAACAAACAA ACAAAAAACA AACTTGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

nle:100584048

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	72.18	0.00e+00	1402.00
IUUC-Aca-004663	Anolis carolinensis	47.66	0.00e+00	894.00
IUUC-Bta-013080	Bos taurus	73.11	0.00e+00	1459.00
IUUC-Cja-018891	Callithrix jacchus	86.59	0.00e+00	1776.00
IUUC-Cfa-020763	Canis familiaris	71.89	0.00e+00	1354.00
IUUC-Cpo-022346	Cavia porcellus	70.06	0.00e+00	1449.00
IUUC-Csa-023049	Chlorocebus sabaeus	95.00	0.00e+00	2018.00
IUUC-Dno-029093	Dasypus novemcinctus	75.54	0.00e+00	1550.00
IUUC-Eca-034098	Equus caballus	76.81	0.00e+00	1483.00
IUUC-Eeu-035028	Erinaceus europaeus	58.96	7.00e-165	574.00
IUUC-Fca-036283	Felis catus	75.05	0.00e+00	1432.00
IUUC-Ggo-045553	Gorilla gorilla	92.05	0.00e+00	1884.00
IUUC-Hsa-046396	Homo sapiens	95.68	0.00e+00	1978.00
IUUC-Loc-052700	Lepisosteus oculatus	42.29	0.00e+00	798.00
IUUC-Laf-054433	Loxodonta africana	72.04	0.00e+00	1526.00
IUUC-Mcc-055014	Macaca mulatta	90.48	0.00e+00	1941.00
IUUC-Mdo-061839	Monodelphis domestica	56.84	0.00e+00	1042.00
IUUC-Mmu-064378	Mus musculus	65.72	0.00e+00	1295.00
IUUC-Mpu-066293	Mustela putorius furo	71.12	0.00e+00	1352.00
IUUC-Mlu-067407	Myotis lucifugus	73.05	0.00e+00	1457.00
IUUC-Opr-070190	Ochotona princeps	59.69	0.00e+00	716.00
IUUC-Ocu-074640	Oryctolagus cuniculus	70.24	0.00e+00	875.00
IUUC-Oga-088780	Otolemur garnettii	70.81	0.00e+00	1439.00
IUUC-Oar-090307	Ovis aries	74.35	0.00e+00	1471.00
IUUC-Ptr-091567	Pan troglodytes	95.39	0.00e+00	1973.00
IUUC-Pan-091802	Papio anubis	89.53	0.00e+00	1889.00
IUUC-Pab-098024	Pongo abelii	78.24	0.00e+00	1554.00
IUUC-Pva-102382	Pteropus vampyrus	69.09	0.00e+00	1365.00
IUUC-Rno-105768	Rattus norvegicus	61.69	0.00e+00	1236.00
IUUC-Sha-106525	Sarcophilus harrisii	54.53	0.00e+00	1111.00
IUUC-Sar-113014	Sorex araneus	60.56	6.00e-160	558.00
IUUC-Vpa-130214	Vicugna pacos	71.32	0.00e+00	1310.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence