iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091567

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03029918

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016272.6	ENSPTRT00000030282.3	ENSPTRP00000027952.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-93	311.9	695	1014

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            d+ k+l vef +E + + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F  +G+l+g++l++ ++ +
   Q: 695  TDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP----EKKRYFL-FGILCGLSLFNLNVAN 776
           688899*************************************************9885....7889995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ ++yk+ll++k sledl+e+ p l ksl+e+++ + +di ++ l+++fs++     ++++++L+p+G +ipV ++Nk++Yv++
   Q: 777  LPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDDADDIGDA-LCIRFSIH----WDQNDVDLIPNGISIPVDQTNKRDYVSK 858
           **************************************99999997.*****855....5779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y+++ ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+iq Fw+++++++ +e+k+
   Q: 859  YIDYIFNVSVKAVYEEFQRGFYTVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKK 945
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G+++++  +f++++  s+++ P+s TC n L LP+Ys++e ++e L++Ai++++gF
   Q: 946  FLFFLTGRDRLHARGIQKME-IVFCCPETFSERDHPTSLTCHNILYLPKYSTMERMEEALQVAINNNRGF 1014
           ********************.88*****9****************************************9 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MYFCWGTDSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA 60
QRGELPEPIQ ALETLTVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTTGAA GTTCAGGCAG CGAGAGTTGA CATGGGGCCA GGGCTGCGCC CCTGGGGCGG 60
GTTGAAGACA GGGTGAGTCT CTTGATATTC AGGAAATCAT CGCGCACCCA GTCACCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	73.46	0.00e+00	1407.00
IUUC-Aca-004663	Anolis carolinensis	46.88	0.00e+00	879.00
IUUC-Bta-013080	Bos taurus	73.63	0.00e+00	1451.00
IUUC-Cja-018891	Callithrix jacchus	86.59	0.00e+00	1750.00
IUUC-Cfa-020763	Canis familiaris	72.39	0.00e+00	1352.00
IUUC-Cpo-022346	Cavia porcellus	70.55	0.00e+00	1451.00
IUUC-Csa-023049	Chlorocebus sabaeus	95.00	0.00e+00	1991.00
IUUC-Dno-029093	Dasypus novemcinctus	76.23	0.00e+00	1549.00
IUUC-Eca-034098	Equus caballus	77.57	0.00e+00	1483.00
IUUC-Eeu-035028	Erinaceus europaeus	59.73	2.00e-168	586.00
IUUC-Fca-036283	Felis catus	74.52	0.00e+00	1430.00
IUUC-Ggo-045553	Gorilla gorilla	93.72	0.00e+00	1914.00
IUUC-Hsa-046396	Homo sapiens	97.45	0.00e+00	2015.00
IUUC-Loc-052700	Lepisosteus oculatus	42.13	0.00e+00	798.00
IUUC-Laf-054433	Loxodonta africana	72.14	0.00e+00	1509.00
IUUC-Mcc-055014	Macaca mulatta	90.49	0.00e+00	1914.00
IUUC-Mdo-061839	Monodelphis domestica	57.38	0.00e+00	1056.00
IUUC-Mmu-064378	Mus musculus	66.80	0.00e+00	1306.00
IUUC-Mpu-066293	Mustela putorius furo	72.11	0.00e+00	1358.00
IUUC-Mlu-067407	Myotis lucifugus	73.47	0.00e+00	1443.00
IUUC-Nle-069978	Nomascus leucogenys	95.39	0.00e+00	2000.00
IUUC-Opr-070190	Ochotona princeps	60.00	0.00e+00	723.00
IUUC-Oga-088780	Otolemur garnettii	71.35	0.00e+00	1430.00
IUUC-Oar-090307	Ovis aries	74.05	0.00e+00	1448.00
IUUC-Pan-091802	Papio anubis	89.53	0.00e+00	1857.00
IUUC-Pab-098024	Pongo abelii	78.38	0.00e+00	1536.00
IUUC-Pva-102382	Pteropus vampyrus	69.80	0.00e+00	1355.00
IUUC-Rno-105768	Rattus norvegicus	62.29	0.00e+00	1232.00
IUUC-Sha-106525	Sarcophilus harrisii	55.26	0.00e+00	1127.00
IUUC-Sar-113014	Sorex araneus	60.56	5.00e-160	558.00
IUUC-Vpa-130214	Vicugna pacos	71.88	0.00e+00	1300.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence