iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013415

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase MARCH8; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING-type E3 ubiquitin transferase MARCH8

Genbank Nucleotide ID

BC119819

Gene Name

MARCH8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019537.5	ENSBTAT00000039901.4	ENSBTAP00000039686.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.72	2.00e-150	528.00	IUUC-Hsa-045936
E3 activity/RING/RING	87.59	2.00e-143	505.00	IUUC-Mmu-063373

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Protein Sequence
(Fasta)

MNMPLHQISA IPSQDATSAR VYRSKTKEKE REEQNEKTLG HSMSHSSNIS KAGGSSVASA 60
PVSSFPRTSV TPSNQDICRI CHCEGDDESP LITPCRCTGS LHFVHQTCLQ QWIKSSDTRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAGCTGCA GCGTCTGCTG CGTCCGCGTC TCCGGCATGC TCCAGGCCGG CGGGGGCGGC 60
CCTGCCGCGA GCTCAGCGCC CACTTGAGGT AACTCCTGCG GCCTTCCGGC CGGCGTACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1064--Adaptive immunity
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0002495--P:antigen processing and presentation of peptide antigen via MHC class II
GO:0045347--P:negative regulation of MHC class II biosynthetic process

KEGG

bta:540667

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001621	Ailuropoda melanoleuca	76.23	6.00e-98	350.00
IUUC-Aca-004316	Anolis carolinensis	72.16	2.00e-102	365.00
IUUC-Cel-018329	Caenorhabditis elegans	49.15	2.00e-11	63.50
IUUC-Cja-019593	Callithrix jacchus	75.78	1.00e-97	348.00
IUUC-Cfa-020901	Canis familiaris	90.66	3.00e-149	520.00
IUUC-Cpo-021679	Cavia porcellus	87.89	5.00e-134	469.00
IUUC-Csa-023704	Chlorocebus sabaeus	89.00	4.00e-148	516.00
IUUC-Cho-024995	Choloepus hoffmanni	88.33	2.00e-59	221.00
IUUC-Cin-025566	Ciona intestinalis	64.00	5.00e-15	74.30
IUUC-Dre-027670	Danio rerio	78.89	2.00e-127	447.00
IUUC-Dno-028902	Dasypus novemcinctus	90.31	4.00e-151	526.00
IUUC-Dor-030770	Dipodomys ordii	56.05	6.00e-64	237.00
IUUC-Dme-031717	Drosophila melanogaster	55.42	1.00e-58	221.00
IUUC-Eca-033918	Equus caballus	89.78	7.00e-122	429.00
IUUC-Eeu-034876	Erinaceus europaeus	81.04	4.00e-100	357.00
IUUC-Fca-035915	Felis catus	76.23	2.00e-97	348.00
IUUC-Gmo-039585	Gadus morhua	76.21	4.00e-123	434.00
IUUC-Gga-040516	Gallus gallus	87.20	4.00e-146	509.00
IUUC-Gac-041554	Gasterosteus aculeatus	76.21	2.00e-123	435.00
IUUC-Ggo-045247	Gorilla gorilla	75.34	4.00e-97	347.00
IUUC-Hsa-045936	Homo sapiens	88.32	5.00e-146	509.00
IUUC-Lch-049853	Latimeria chalumnae	82.01	8.00e-138	482.00
IUUC-Loc-052142	Lepisosteus oculatus	76.53	1.00e-123	435.00
IUUC-Laf-054075	Loxodonta africana	90.22	4.00e-122	430.00
IUUC-Mcc-054834	Macaca mulatta	88.66	1.00e-147	515.00
IUUC-Meu-056594	Macropus eugenii	88.57	2.00e-32	132.00
IUUC-Mga-059662	Meleagris gallopavo	69.80	5.00e-98	350.00
IUUC-Mmr-061603	Microcebus murinus	91.07	1.00e-154	538.00
IUUC-Mdo-062578	Monodelphis domestica	87.93	9.00e-148	515.00
IUUC-Mmu-063373	Mus musculus	86.90	7.00e-143	499.00
IUUC-Nle-069774	Nomascus leucogenys	88.66	8.00e-147	512.00
IUUC-Oan-072984	Ornithorhynchus anatinus	72.55	1.00e-102	365.00
IUUC-Ocu-074342	Oryctolagus cuniculus	78.20	2.00e-123	434.00
IUUC-Ola-086344	Oryzias latipes	76.15	2.00e-111	394.00
IUUC-Oga-088670	Otolemur garnettii	88.00	9.00e-128	449.00
IUUC-Ptr-090574	Pan troglodytes	87.29	1.00e-145	508.00
IUUC-Pan-092925	Papio anubis	87.63	1.00e-146	511.00
IUUC-Psi-093085	Pelodiscus sinensis	86.85	1.00e-135	475.00
IUUC-Pma-094229	Petromyzon marinus	60.00	6.00e-74	270.00
IUUC-Pfo-097524	Poecilia formosa	64.52	2.00e-116	412.00
IUUC-Pab-098165	Pongo abelii	88.66	2.00e-147	514.00
IUUC-Pca-100362	Procavia capensis	54.26	2.00e-63	235.00
IUUC-Rno-105837	Rattus norvegicus	86.90	7.00e-143	499.00
IUUC-Sha-107014	Sarcophilus harrisii	88.05	6.00e-119	421.00
IUUC-Sar-113258	Sorex araneus	80.71	3.00e-93	334.00
IUUC-Sbi-113840	Sorghum bicolor	29.94	2.00e-09	56.20
IUUC-Tgu-116539	Taeniopygia guttata	65.60	5.00e-101	360.00
IUUC-Tru-117951	Takifugu rubripes	75.29	2.00e-103	368.00
IUUC-Tsy-119324	Tarsius syrichta	75.78	5.00e-97	347.00
IUUC-Tni-120496	Tetraodon nigroviridis	75.29	6.00e-107	379.00
IUUC-Tbe-127567	Tupaia belangeri	74.44	2.00e-95	341.00
IUUC-Ttr-129098	Tursiops truncatus	75.45	2.00e-96	345.00
IUUC-Vpa-130287	Vicugna pacos	55.61	3.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence