iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045134

UUCD1 version

UUC-GoG-00505

Ensembl Protein ID

ENSGGOP00000012839.2

UniProt Accession

G3RBI4; G3RBI4_GORGO

Protein Name

Uncharacterized protein

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000013126.2	ENSGGOT00000013210.2	ENSGGOP00000012839.2
ENSGGOG00000013126.2	ENSGGOT00000022290.1	ENSGGOP00000025373.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-93	314.0	4150	4485
E3 adaptor/Cullin RING/DCX/DWD	7.40e-17	61.2	3070	3100

Active Site

Position(s)	Description	Evidence
4454	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4150 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4236
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4237 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4323
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e  ++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4324 EYVERAIEYRLHEMDRQQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4409
           ****************************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4410 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4485
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3070 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3100
           55416677.*9778****************97 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACCTCCTG CCAGAGGCTG CCAGCTCCAG AGCAGTGTGG CCAGCGGTGT GCACTGGCTT 60
TCTTCCGGTC CCTGATGCCA TGATGAAAAA TCAAGCGTGG AGGTGTGCTC CGAGCATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	92.94	0.00e+00	4730.00
IUUC-Apl-003461	Anas platyrhynchos	87.97	0.00e+00	4539.00
IUUC-Aca-004452	Anolis carolinensis	79.18	0.00e+00	3960.00
IUUC-Ame-011268	Astyanax mexicanus	59.73	0.00e+00	2095.00
IUUC-Bta-013213	Bos taurus	92.24	0.00e+00	4746.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	3.00e-52	199.00
IUUC-Bra-017584	Brassica rapa	34.72	6.00e-50	192.00
IUUC-Cja-019298	Callithrix jacchus	92.62	0.00e+00	4788.00
IUUC-Cfa-021213	Canis familiaris	92.84	0.00e+00	4798.00
IUUC-Cpo-021674	Cavia porcellus	96.51	0.00e+00	3424.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.44	2.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	93.53	0.00e+00	4821.00
IUUC-Cho-024567	Choloepus hoffmanni	86.76	0.00e+00	1568.00
IUUC-Dre-028289	Danio rerio	73.28	0.00e+00	3556.00
IUUC-Dno-029988	Dasypus novemcinctus	92.10	0.00e+00	4736.00
IUUC-Dor-030636	Dipodomys ordii	94.62	0.00e+00	2149.00
IUUC-Ete-032598	Echinops telfairi	84.57	0.00e+00	1363.00
IUUC-Eca-033754	Equus caballus	92.77	0.00e+00	4744.00
IUUC-Eeu-034702	Erinaceus europaeus	95.15	0.00e+00	1180.00
IUUC-Fca-035900	Felis catus	92.83	0.00e+00	4765.00
IUUC-Fal-037034	Ficedula albicollis	86.42	0.00e+00	4370.00
IUUC-Gmo-038634	Gadus morhua	90.58	0.00e+00	1217.00
IUUC-Gga-040321	Gallus gallus	87.72	0.00e+00	4529.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.20	0.00e+00	2093.00
IUUC-Gma-043808	Glycine max	33.42	3.00e-46	180.00
IUUC-Hsa-046516	Homo sapiens	93.88	0.00e+00	4783.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	97.68	0.00e+00	2571.00
IUUC-Lch-049903	Latimeria chalumnae	81.00	0.00e+00	4156.00
IUUC-Lpe-051165	Leersia perrieri	33.58	6.00e-50	191.00
IUUC-Loc-052149	Lepisosteus oculatus	80.84	0.00e+00	4081.00
IUUC-Laf-053426	Loxodonta africana	92.13	0.00e+00	4699.00
IUUC-Mcc-055826	Macaca mulatta	93.81	0.00e+00	4847.00
IUUC-Meu-056521	Macropus eugenii	77.52	0.00e+00	1623.00
IUUC-Mga-059567	Meleagris gallopavo	91.20	0.00e+00	2014.00
IUUC-Mmr-061512	Microcebus murinus	93.88	0.00e+00	4718.00
IUUC-Mdo-062177	Monodelphis domestica	85.39	0.00e+00	4380.00
IUUC-Mmu-064373	Mus musculus	91.44	0.00e+00	4685.00
IUUC-Mpu-066148	Mustela putorius furo	92.06	0.00e+00	4679.00
IUUC-Mlu-067680	Myotis lucifugus	92.38	0.00e+00	4728.00
IUUC-Nle-069633	Nomascus leucogenys	93.46	0.00e+00	4796.00
IUUC-Opr-070609	Ochotona princeps	95.97	0.00e+00	1458.00
IUUC-Ont-071249	Oreochromis niloticus	76.00	0.00e+00	3865.00
IUUC-Oan-073157	Ornithorhynchus anatinus	87.74	0.00e+00	4472.00
IUUC-Ocu-074841	Oryctolagus cuniculus	92.66	0.00e+00	4773.00
IUUC-Oba-075262	Oryza barthii	33.92	1.00e-48	187.00
IUUC-Obr-076115	Oryza brachyantha	34.10	5.00e-48	185.00
IUUC-Ogl-077586	Oryza glaberrima	33.92	1.00e-48	187.00
IUUC-Ogu-078796	Oryza glumaepatula	33.67	6.00e-48	184.00
IUUC-Oin-079298	Oryza indica	33.67	5.00e-48	185.00
IUUC-Olo-080768	Oryza longistaminata	35.07	2.00e-53	202.00
IUUC-Ome-081908	Oryza meridionalis	34.15	1.00e-47	183.00
IUUC-Oni-082049	Oryza nivara	33.67	6.00e-48	184.00
IUUC-Opu-083608	Oryza punctata	33.42	2.00e-49	189.00
IUUC-Oru-084712	Oryza rufipogon	33.67	6.00e-48	184.00
IUUC-Osa-086078	Oryza sativa	33.67	6.00e-48	184.00
IUUC-Ola-086889	Oryzias latipes	74.04	0.00e+00	3687.00
IUUC-Oga-088459	Otolemur garnettii	90.69	0.00e+00	4634.00
IUUC-Oar-089888	Ovis aries	92.10	0.00e+00	4707.00
IUUC-Ptr-091114	Pan troglodytes	93.88	0.00e+00	4826.00
IUUC-Pan-092442	Papio anubis	93.81	0.00e+00	4851.00
IUUC-Psi-093833	Pelodiscus sinensis	92.37	0.00e+00	3330.00
IUUC-Pma-094275	Petromyzon marinus	74.50	0.00e+00	1632.00
IUUC-Ppa-095790	Physcomitrella patens	36.17	2.00e-55	209.00
IUUC-Pfo-097262	Poecilia formosa	73.91	0.00e+00	3585.00
IUUC-Pab-097760	Pongo abelii	98.56	0.00e+00	3491.00
IUUC-Pop-099121	Populus trichocarpa	36.34	1.00e-51	198.00
IUUC-Pca-100465	Procavia capensis	96.29	0.00e+00	3419.00
IUUC-Ppe-101345	Prunus persica	33.76	8.00e-52	199.00
IUUC-Pva-102950	Pteropus vampyrus	90.82	0.00e+00	3887.00
IUUC-Rno-104892	Rattus norvegicus	91.33	0.00e+00	4667.00
IUUC-Sha-106633	Sarcophilus harrisii	88.69	0.00e+00	4497.00
IUUC-Smo-108827	Selaginella moellendorffii	35.14	1.00e-51	198.00
IUUC-Sit-110415	Setaria italica	35.86	9.00e-53	201.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	1.00e-53	205.00
IUUC-Stu-112166	Solanum tuberosum	31.97	4.00e-49	190.00
IUUC-Sar-113251	Sorex araneus	80.64	0.00e+00	2037.00
IUUC-Ssc-116391	Sus scrofa	91.96	0.00e+00	4716.00
IUUC-Tgu-116554	Taeniopygia guttata	87.10	0.00e+00	4427.00
IUUC-Tru-118695	Takifugu rubripes	75.63	0.00e+00	3846.00
IUUC-Tsy-119647	Tarsius syrichta	89.04	0.00e+00	3080.00
IUUC-Tni-120707	Tetraodon nigroviridis	75.70	0.00e+00	3820.00
IUUC-Tbe-127346	Tupaia belangeri	89.94	0.00e+00	2598.00
IUUC-Ttr-128542	Tursiops truncatus	89.36	0.00e+00	3073.00
IUUC-Vpa-130611	Vicugna pacos	90.86	0.00e+00	3747.00
IUUC-Xtr-131933	Xenopus tropicalis	79.60	0.00e+00	4071.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence