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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-064122
Ensembl Protein ID ENSMUSP00000029650.8
UniProt Accession Q9D168; Q3U2Q5; Q921U2; INT12_MOUSE
Genbank Protein ID BAB23052.1; BAE33085.1; AAH10657.1; AAH23801.1; AAH46996.1
Protein Name Integrator complex subunit 12; PHD finger protein 22
Genbank Nucleotide ID AK003874; AK155162; BC010657; BC023801; BC046996
Gene Name Ints12; Phf22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028016.9 ENSMUST00000029650.8 ENSMUSP00000029650.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.90e-08 34.9 161 213
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD

   S: 4    ClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek..wiCpkCrs 53
    C vC++ + + +lveC++C++ +H++C+k++v ++ n+ + w+C +C++
   Q: 161 CVVCRQMTVASGnQLVECQECHNLYHQDCHKPQVTDKEVNDPRlvWYCARCTR 213
    ******9988756********************888888876689******86 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity).
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity).
Protein Sequence
(Fasta)
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPT QKDVEPPKIS 60
STKSLSIKQE PKTSSSLPSG SSNGKVLTAE KIKKEAEKRP ADKMKDVTEG IDVPKKPRLE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-064122|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
TTCCTGCTGT CTCACTCGGA AACGTTCCCC TTCCGACCTG TTGCGGGAAC CTTTGTTTCT 60
CTCTTCTTAA AGCTGGTGAG GGCGGGGACG GATTCGAAGA GAGCTACCGG GAACCGACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-064122|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD

SMART

SM00249--PHD

Gene Ontology

GO:0032039--C:integrator complex
GO:0008270--F:zinc ion binding
GO:0016180--P:snRNA processing

KEGG mmu:71793
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001485 Ailuropoda melanoleuca 89.58 1.00e-162 565.00
IUUC-Apl-003539 Anas platyrhynchos 75.94 2.00e-143 501.00
IUUC-Bta-013090 Bos taurus 90.47 4.00e-149 521.00
IUUC-Cja-019984 Callithrix jacchus 90.91 1.00e-156 546.00
IUUC-Cfa-020068 Canis familiaris 91.13 6.00e-173 600.00
IUUC-Cpo-021446 Cavia porcellus 88.03 7.00e-139 487.00
IUUC-Csa-023385 Chlorocebus sabaeus 91.35 3.00e-164 571.00
IUUC-Cho-025018 Choloepus hoffmanni 90.24 1.00e-155 543.00
IUUC-Dre-027546 Danio rerio 65.01 2.00e-95 342.00
IUUC-Dno-029989 Dasypus novemcinctus 90.24 6.00e-154 537.00
IUUC-Eca-033999 Equus caballus 89.14 5.00e-158 550.00
IUUC-Fca-035522 Felis catus 90.69 7.00e-163 566.00
IUUC-Gga-041056 Gallus gallus 75.55 4.00e-142 498.00
IUUC-Gac-042508 Gasterosteus aculeatus 60.24 4.00e-89 321.00
IUUC-Ggo-044647 Gorilla gorilla 89.97 1.00e-121 429.00
IUUC-Hsa-046655 Homo sapiens 91.13 2.00e-153 535.00
IUUC-Loc-052933 Lepisosteus oculatus 69.97 4.00e-98 352.00
IUUC-Laf-054471 Loxodonta africana 90.02 2.00e-164 572.00
IUUC-Mcc-055568 Macaca mulatta 91.35 3.00e-164 571.00
IUUC-Meu-056037 Macropus eugenii 88.17 1.00e-140 492.00
IUUC-Mga-059569 Meleagris gallopavo 74.67 7.00e-140 490.00
IUUC-Mmr-061180 Microcebus murinus 91.80 4.00e-158 551.00
IUUC-Mdo-062528 Monodelphis domestica 85.53 2.00e-147 516.00
IUUC-Mpu-066477 Mustela putorius furo 91.13 6.00e-162 563.00
IUUC-Mlu-067391 Myotis lucifugus 90.69 6.00e-154 537.00
IUUC-Nle-069599 Nomascus leucogenys 90.69 1.00e-146 513.00
IUUC-Opr-070713 Ochotona princeps 87.80 6.00e-141 494.00
IUUC-Ont-072565 Oreochromis niloticus 63.96 3.00e-85 308.00
IUUC-Oan-073115 Ornithorhynchus anatinus 83.96 1.00e-107 382.00
IUUC-Ocu-074717 Oryctolagus cuniculus 90.69 3.00e-153 534.00
IUUC-Ola-087458 Oryzias latipes 68.42 2.00e-88 319.00
IUUC-Oga-088704 Otolemur garnettii 92.02 2.00e-158 551.00
IUUC-Oar-089184 Ovis aries 90.91 5.00e-151 527.00
IUUC-Ptr-091021 Pan troglodytes 91.13 4.00e-157 548.00
IUUC-Pan-091963 Papio anubis 91.35 3.00e-164 571.00
IUUC-Psi-093012 Pelodiscus sinensis 78.37 5.00e-135 474.00
IUUC-Pab-097870 Pongo abelii 90.91 2.00e-153 535.00
IUUC-Pca-100164 Procavia capensis 90.02 2.00e-162 565.00
IUUC-Pva-102873 Pteropus vampyrus 90.47 6.00e-154 537.00
IUUC-Rno-104840 Rattus norvegicus 96.22 2.00e-155 541.00
IUUC-Sha-106551 Sarcophilus harrisii 85.30 7.00e-145 507.00
IUUC-Tsy-119236 Tarsius syrichta 86.25 6.00e-162 563.00
IUUC-Tni-120510 Tetraodon nigroviridis 65.25 1.00e-97 349.00
IUUC-Tbe-127947 Tupaia belangeri 84.70 3.00e-141 495.00
Created Date 25-Jun-2017

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