iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000187260.15	ENST00000628331.1	ENSP00000486705.1
ENSG00000187260.15	ENST00000469830.2	ENSP00000419162.2
ENSG00000187260.15	ENST00000334493.10	ENSP00000335522.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-24	86.2	17	49
UBD/Beta-Prp	4.00e-63	215.1	7	241

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 8    claf....sd.tllvsGsdDgtikvWDlrtgvl 35
           ++++    +d  +l++Gs Dgt ++W++ +g +
   Q: 17   GINWlslsPDgQRLLTGSEDGTARLWSTADGQC 49
           488999999999***************999988 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsg 135
           +lr   +h ++++ +++spdg+ l+tgseD+t+++w+  +g+c   l+ghe++v+ +++    +   + s+d tir wd+ tgqcl+ + +g
   Q: 7    ALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED--EAAFTCSADCTIRRWDVLTGQCLQ-VYRG 95
           566779*****************************************************99..888899999***************.**** PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng..............kelvsgsldgtvklwdlqtge 213
           h+++vn + v    n l+s+s+Drt r+W++  g++ r+++g h + v  l+++                   lv+gs+dgt k+w++ +g 
   Q: 96   HTSIVNRILVAN--NQLFSSSYDRTARVWSVDKGQMSREFRG-HRNCVLTLAYSAPWdlpstpcaeeaaagGLLVTGSTDGTAKVWQVASGC 184
           **********99..99*************************9.********955544555577778888889******************** PP
   S: 214  cvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
           c +tl+ght  v+++ ++  ++   +gs D +ir Wd+ sg+ l+++  h+ svi+ 
   Q: 185  CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
           ******************************************************995 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MGGGGSALRV CADHRGGINW LSLSPDGQRL LTGSEDGTAR LWSTADGQCC ALLQGHESYV 60
TFCQLEDEAA FTCSADCTIR RWDVLTGQCL QVYRGHTSIV NRILVANNQL FSSSYDRTAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCCCGTCC CCAGCGAAGT CGGCGCCGGA ACTGCCCTAA TGGAAACCAG CCGCCGGGCG 60
CTCCGGGAGG GCTCAGGCCG ACCCCGGGGT CCATTAGAGG CGCCCCAGGC CGAGGGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

KEGG

hsa:349136

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001210	Ailuropoda melanoleuca	92.11	2.00e-57	215.00
IUUC-Apl-004074	Anas platyrhynchos	62.16	2.00e-47	182.00
IUUC-Aca-004913	Anolis carolinensis	69.11	7.00e-94	337.00
IUUC-Bta-013331	Bos taurus	89.67	5.00e-126	444.00
IUUC-Cja-019968	Callithrix jacchus	95.45	4.00e-135	474.00
IUUC-Cfa-020996	Canis familiaris	78.11	5.00e-157	547.00
IUUC-Cpo-021901	Cavia porcellus	92.02	5.00e-97	348.00
IUUC-Csa-023634	Chlorocebus sabaeus	95.92	3.00e-176	611.00
IUUC-Cho-024618	Choloepus hoffmanni	68.72	6.00e-88	316.00
IUUC-Dno-029991	Dasypus novemcinctus	86.53	5.00e-121	427.00
IUUC-Dor-031111	Dipodomys ordii	74.19	2.00e-90	325.00
IUUC-Ete-032821	Echinops telfairi	75.63	4.00e-45	174.00
IUUC-Eca-034385	Equus caballus	92.63	7.00e-103	367.00
IUUC-Fca-035672	Felis catus	89.36	1.00e-95	342.00
IUUC-Fal-036601	Ficedula albicollis	70.73	3.00e-99	355.00
IUUC-Gga-040454	Gallus gallus	71.14	4.00e-100	358.00
IUUC-Ggo-045560	Gorilla gorilla	98.42	8.00e-108	384.00
IUUC-Itr-048107	Ictidomys tridecemlineatus	65.09	6.00e-90	324.00
IUUC-Lch-049458	Latimeria chalumnae	61.69	3.00e-85	308.00
IUUC-Loc-052940	Lepisosteus oculatus	59.83	4.00e-79	288.00
IUUC-Laf-053931	Loxodonta africana	89.71	2.00e-124	439.00
IUUC-Mcc-055629	Macaca mulatta	95.87	2.00e-135	476.00
IUUC-Meu-056313	Macropus eugenii	74.79	6.00e-105	374.00
IUUC-Mga-059418	Meleagris gallopavo	59.19	2.00e-101	362.00
IUUC-Mmr-060958	Microcebus murinus	81.79	1.00e-166	578.00
IUUC-Mdo-061978	Monodelphis domestica	71.96	7.00e-78	284.00
IUUC-Mmu-063108	Mus musculus	90.08	2.00e-127	448.00
IUUC-Mpu-066501	Mustela putorius furo	93.80	2.00e-131	461.00
IUUC-Mlu-067322	Myotis lucifugus	91.74	8.00e-130	456.00
IUUC-Nle-069571	Nomascus leucogenys	98.42	6.00e-108	384.00
IUUC-Opr-070837	Ochotona princeps	80.65	2.00e-50	191.00
IUUC-Oan-072939	Ornithorhynchus anatinus	65.66	5.00e-68	251.00
IUUC-Ocu-074607	Oryctolagus cuniculus	91.80	1.00e-122	432.00
IUUC-Oga-088689	Otolemur garnettii	94.63	4.00e-135	474.00
IUUC-Oar-089291	Ovis aries	76.95	7.00e-101	359.00
IUUC-Ptr-090482	Pan troglodytes	99.17	1.00e-140	492.00
IUUC-Pan-092460	Papio anubis	96.69	2.00e-136	479.00
IUUC-Psi-093758	Pelodiscus sinensis	71.19	1.00e-100	359.00
IUUC-Pma-094422	Petromyzon marinus	46.94	4.00e-51	194.00
IUUC-Pva-102148	Pteropus vampyrus	84.49	4.00e-86	311.00
IUUC-Rno-106067	Rattus norvegicus	90.08	3.00e-127	447.00
IUUC-Sha-107050	Sarcophilus harrisii	69.58	6.00e-104	370.00
IUUC-Ssc-116247	Sus scrofa	90.97	1.00e-74	273.00
IUUC-Tgu-116656	Taeniopygia guttata	63.70	4.00e-47	181.00
IUUC-Tsy-118911	Tarsius syrichta	81.01	5.00e-108	383.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence