iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069081

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Tripartite motif-containing protein 5

Genbank Nucleotide ID

ADFV01111912

Gene Name

TRIM5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000017376.2	ENSNLET00000022162.2	ENSNLEP00000021093.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.10e-09	35.9	15	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ Cl  ++    +    +e +CP+Cr
   Q: 15   CPICLELLTQ-PLSLDCGHSFCQACLtaNHK--TSMPDEGERSCPVCR 59
           ********99.***************76444..3445999*******8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKTSMPDE GERSCPVCRI 60
SYQHKNIRNR HVANIVEKLR EVKLSPEEGQ KVDHCARHGE KLLLFCREDR KVICWLCERS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCTG GAATCCTGGT TAATGTAAAG GAGGAGGTGA CCTGCCCCAT CTGCCTGGAA 60
CTCCTGACAC AACCCCTGAG TCTGGACTGC GGCCACAGCT TCTGCCAAGC ATGCCTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	56.02	1.00e-148	519.00
IUUC-Cja-019944	Callithrix jacchus	67.21	0.00e+00	633.00
IUUC-Csa-023609	Chlorocebus sabaeus	79.22	0.00e+00	832.00
IUUC-Dor-030700	Dipodomys ordii	51.11	6.00e-138	483.00
IUUC-Ete-033021	Echinops telfairi	52.01	2.00e-115	409.00
IUUC-Ggo-044783	Gorilla gorilla	86.46	0.00e+00	825.00
IUUC-Hsa-046573	Homo sapiens	88.66	0.00e+00	870.00
IUUC-Mcc-055525	Macaca mulatta	82.49	0.00e+00	846.00
IUUC-Mmr-061336	Microcebus murinus	60.64	4.00e-144	504.00
IUUC-Mlu-067695	Myotis lucifugus	59.01	6.00e-150	523.00
IUUC-Ncr-068857	Neurospora crassa	61.76	6.00e-06	47.00
IUUC-Opr-071057	Ochotona princeps	52.34	1.00e-130	459.00
IUUC-Ptr-090927	Pan troglodytes	89.07	0.00e+00	868.00
IUUC-Pan-092730	Papio anubis	82.49	0.00e+00	844.00
IUUC-Pab-098782	Pongo abelii	89.68	0.00e+00	885.00
IUUC-Sar-113094	Sorex araneus	47.58	3.00e-108	385.00
IUUC-Tsy-119055	Tarsius syrichta	60.00	9.00e-161	559.00
IUUC-Tbe-127426	Tupaia belangeri	53.21	5.00e-131	461.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence