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Tag Content
iUUCD ID IUUC-Ocu-074460
Ensembl Protein ID ENSOCUP00000007636.3
UniProt Accession G1SW05; G1SW05_RABIT
Protein Name Ubiquitin-related modifier 1
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000008848.2 ENSOCUT00000008844.2 ENSOCUP00000007636.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 42.42 8.00e-17 79.70 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
PLSVEVEFGG GAELLFDGVK KHQVTLPGQE EPWDIRNLLV WIKKNLLKER PELFIQGDSV 60
RPGILVLVND ADWELLGELD YQLQDQDNIL FISTLHGG 98
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Protein Fasta Sequence


>IUUC-Ocu-074460|ULD,UBQ_Other|Oryctolagus cuniculus
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Nucleotide Sequence
(Fasta)
CGCCCTTGTC AGTGGAGGTG GAGTTCGGGT GAGTCACGGA GTTGGGGCGC CGCAGGGAAG 60
GGTTGAAGCT GTCGGGCCCG GGACTCACCT CCCTTTGCCT TGGGGTCTGA CACGGCCGAG 120
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Nucleotide Fasta Sequence


>IUUC-Ocu-074460|ULD,UBQ_Other|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 96.94 2.00e-51 192.00
IUUC-Atr-003089 Amborella trichopoda 57.58 3.00e-30 122.00
IUUC-Apl-003382 Anas platyrhynchos 87.91 2.00e-43 166.00
IUUC-Aca-004981 Anolis carolinensis 81.63 3.00e-46 175.00
IUUC-Aly-005517 Arabidopsis lyrata 55.32 1.00e-27 114.00
IUUC-Ath-006718 Arabidopsis thaliana 57.14 3.00e-24 102.00
IUUC-Ago-007917 Ashbya gossypii 41.41 1.00e-19 87.00
IUUC-Acl-008054 Aspergillus clavatus 68.00 1.00e-15 73.60
IUUC-Afl-008704 Aspergillus flavus 56.18 4.00e-21 92.00
IUUC-Aor-009890 Aspergillus oryzae 58.42 8.00e-26 108.00
IUUC-Bta-012448 Bos taurus 96.94 4.00e-51 191.00
IUUC-Bci-013865 Botrytis cinerea 47.52 4.00e-22 95.50
IUUC-Bdi-014980 Brachypodium distachyon 61.04 8.00e-24 101.00
IUUC-Bol-016055 Brassica oleracea 56.25 9.00e-24 100.00
IUUC-Bra-016845 Brassica rapa 56.25 9.00e-24 100.00
IUUC-Cel-018485 Caenorhabditis elegans 35.35 2.00e-11 60.10
IUUC-Cja-019587 Callithrix jacchus 96.94 2.00e-51 192.00
IUUC-Cfa-020653 Canis familiaris 97.96 3.00e-51 192.00
IUUC-Cpo-021622 Cavia porcellus 96.94 2.00e-51 192.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 51.02 5.00e-25 105.00
IUUC-Csa-023756 Chlorocebus sabaeus 97.37 6.00e-39 152.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 46.53 2.00e-21 94.00
IUUC-Cne-026953 Cryptococcus neoformans 56.31 1.00e-27 115.00
IUUC-Cme-027314 Cyanidioschyzon merolae 43.75 6.00e-18 81.60
IUUC-Dre-027884 Danio rerio 76.53 6.00e-43 164.00
IUUC-Dno-029262 Dasypus novemcinctus 92.31 2.00e-37 148.00
IUUC-Dor-030601 Dipodomys ordii 63.27 1.00e-25 107.00
IUUC-Dme-031893 Drosophila melanogaster 63.92 2.00e-32 129.00
IUUC-Ete-032773 Echinops telfairi 91.40 3.00e-46 175.00
IUUC-Eca-034187 Equus caballus 97.96 1.00e-51 193.00
IUUC-Eeu-034808 Erinaceus europaeus 94.90 4.00e-50 188.00
IUUC-Fca-036107 Felis catus 98.98 5.00e-52 194.00
IUUC-Fal-036607 Ficedula albicollis 86.81 4.00e-43 164.00
IUUC-Fox-037698 Fusarium oxysporum 48.51 3.00e-23 99.80
IUUC-Gmo-039492 Gadus morhua 74.49 3.00e-42 162.00
IUUC-Ggr-039965 Gaeumannomyces graminis 49.50 7.00e-21 92.80
IUUC-Gga-041268 Gallus gallus 86.73 2.00e-47 179.00
IUUC-Gac-042111 Gasterosteus aculeatus 78.57 7.00e-45 171.00
IUUC-Gma-043240 Glycine max 53.57 1.00e-22 97.10
IUUC-Ggo-045176 Gorilla gorilla 94.74 3.00e-30 123.00
IUUC-Hsa-046077 Homo sapiens 93.88 1.00e-42 164.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 94.38 1.00e-37 147.00
IUUC-Kpa-049157 Komagataella pastoris 48.48 9.00e-20 87.80
IUUC-Lch-049889 Latimeria chalumnae 79.59 2.00e-44 169.00
IUUC-Lpe-050783 Leersia perrieri 55.42 2.00e-22 96.70
IUUC-Loc-052400 Lepisosteus oculatus 77.55 1.00e-43 166.00
IUUC-Lma-053259 Leptosphaeria maculans 45.54 6.00e-21 92.00
IUUC-Laf-053596 Loxodonta africana 94.00 2.00e-49 186.00
IUUC-Mcc-054845 Macaca mulatta 89.80 1.00e-46 176.00
IUUC-Meu-055968 Macropus eugenii 92.86 7.00e-50 187.00
IUUC-Mor-057126 Magnaporthe oryzae 45.54 3.00e-19 87.00
IUUC-Mpo-057311 Magnaporthe poae 50.50 3.00e-22 97.10
IUUC-Mtr-058266 Medicago truncatula 51.16 3.00e-22 96.30
IUUC-Mla-058847 Melampsora laricipopulina 41.75 5.00e-13 66.20
IUUC-Mga-059468 Meleagris gallopavo 87.91 1.00e-43 166.00
IUUC-Mvi-060235 Microbotryum violaceum 36.49 9.00e-19 85.90
IUUC-Mdo-061948 Monodelphis domestica 89.80 9.00e-49 184.00
IUUC-Mmu-063946 Mus musculus 94.90 3.00e-50 189.00
IUUC-Mac-064812 Musa acuminata 58.33 4.00e-25 105.00
IUUC-Mpu-066763 Mustela putorius furo 95.92 4.00e-50 188.00
IUUC-Mlu-066970 Myotis lucifugus 98.68 5.00e-39 151.00
IUUC-Ncr-068824 Neurospora crassa 45.54 3.00e-20 89.70
IUUC-Nle-069849 Nomascus leucogenys 96.05 2.00e-38 150.00
IUUC-Opr-070227 Ochotona princeps 96.94 2.00e-51 192.00
IUUC-Ont-072530 Oreochromis niloticus 80.41 8.00e-45 171.00
IUUC-Oan-073191 Ornithorhynchus anatinus 82.47 2.00e-42 162.00
IUUC-Oba-075499 Oryza barthii 64.06 4.00e-22 97.10
IUUC-Obr-076896 Oryza brachyantha 55.00 2.00e-21 95.10
IUUC-Ogl-077834 Oryza glaberrima 64.06 1.00e-22 97.40
IUUC-Ogu-078622 Oryza glumaepatula 64.06 1.00e-22 97.40
IUUC-Oin-079358 Oryza indica 64.06 4.00e-22 97.80
IUUC-Olo-081035 Oryza longistaminata 49.51 4.00e-23 100.00
IUUC-Oni-082425 Oryza nivara 64.06 1.00e-22 97.40
IUUC-Opu-083461 Oryza punctata 63.49 8.00e-22 95.90
IUUC-Oru-084875 Oryza rufipogon 57.75 1.00e-20 90.50
IUUC-Oga-089128 Otolemur garnettii 97.96 2.00e-51 192.00
IUUC-Oar-089896 Ovis aries 96.94 4.00e-51 191.00
IUUC-Ptr-091618 Pan troglodytes 94.74 3.00e-30 123.00
IUUC-Pan-092238 Papio anubis 97.37 7.00e-39 152.00
IUUC-Psi-093879 Pelodiscus sinensis 84.69 2.00e-46 176.00
IUUC-Pma-094484 Petromyzon marinus 78.48 2.00e-33 133.00
IUUC-Ppa-095801 Physcomitrella patens 55.56 3.00e-22 95.90
IUUC-Pfo-097192 Poecilia formosa 80.61 7.00e-45 171.00
IUUC-Pab-098203 Pongo abelii 92.86 3.00e-42 162.00
IUUC-Pop-099614 Populus trichocarpa 57.14 1.00e-23 100.00
IUUC-Pca-100507 Procavia capensis 100.00 4.00e-39 152.00
IUUC-Ppe-101174 Prunus persica 55.56 2.00e-28 116.00
IUUC-Pva-102735 Pteropus vampyrus 94.90 1.00e-47 180.00
IUUC-Pgr-103510 Puccinia graminis 40.78 8.00e-13 65.50
IUUC-Ptt-103918 Puccinia triticina 36.89 5.00e-11 59.30
IUUC-Pte-104173 Pyrenophora teres 47.52 8.00e-23 98.20
IUUC-Pyt-104806 Pyrenophora triticirepentis 47.52 1.00e-22 97.80
IUUC-Rno-105820 Rattus norvegicus 95.92 1.00e-50 190.00
IUUC-Sce-106366 Saccharomyces cerevisiae 42.42 3.00e-17 79.70
IUUC-Sja-107727 Schizosaccharomyces japonicus 42.71 5.00e-17 79.30
IUUC-Spo-108074 Schizosaccharomyces pombe 39.80 1.00e-09 54.30
IUUC-Smo-108944 Selaginella moellendorffii 58.43 9.00e-26 107.00
IUUC-Sit-110277 Setaria italica 54.76 2.00e-23 99.80
IUUC-Sly-111505 Solanum lycopersicum 55.95 6.00e-25 104.00
IUUC-Stu-112076 Solanum tuberosum 57.14 2.00e-25 106.00
IUUC-Sbi-114274 Sorghum bicolor 58.44 1.00e-23 101.00
IUUC-Sre-114953 Sporisorium reilianum 57.84 3.00e-27 112.00
IUUC-Ssc-115418 Sus scrofa 95.92 5.00e-51 191.00
IUUC-Tgu-117311 Taeniopygia guttata 86.81 5.00e-43 164.00
IUUC-Tru-118598 Takifugu rubripes 82.02 8.00e-41 157.00
IUUC-Tni-120109 Tetraodon nigroviridis 76.77 1.00e-41 160.00
IUUC-Tca-120942 Theobroma cacao 55.42 5.00e-23 98.60
IUUC-Tre-122099 Trichoderma reesei 48.94 2.00e-16 77.00
IUUC-Tvi-122285 Trichoderma virens 52.48 2.00e-20 90.50
IUUC-Tae-125193 Triticum aestivum 55.42 8.00e-23 97.80
IUUC-Tur-126677 Triticum urartu 48.42 3.00e-20 90.10
IUUC-Tme-127120 Tuber melanosporum 49.02 2.00e-23 100.00
IUUC-Tbe-128050 Tupaia belangeri 68.37 1.00e-31 127.00
IUUC-Ttr-129019 Tursiops truncatus 93.88 5.00e-48 181.00
IUUC-Uma-129483 Ustilago maydis 55.88 5.00e-25 105.00
IUUC-Vda-129690 Verticillium dahliae 41.96 3.00e-17 79.70
IUUC-Vvi-131174 Vitis vinifera 59.04 2.00e-24 102.00
IUUC-Xma-133862 Xiphophorus maculatus 80.61 7.00e-45 171.00
IUUC-Yli-134398 Yarrowia lipolytica 46.46 4.00e-19 85.50
IUUC-Zma-134964 Zea mays 57.32 3.00e-22 95.90
Created Date 25-Jun-2017

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