iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000008899.4	ENSPTRT00000016404.3	ENSPTRP00000015180.3
ENSPTRG00000008899.4	ENSPTRT00000016406.4	ENSPTRP00000015182.4
ENSPTRG00000008899.4	ENSPTRT00000073756.1	ENSPTRP00000060039.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	9.20e-17	60.7	375	420
E3 adaptor/Cullin RING/DCX/DWD	5.50e-32	108.4	169	203
UBD/Beta-Prp	1.90e-48	165.1	135	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++++SLqhLCR+++rr +++q++   ++LP+P++L ++L+y+
   Q: 375  VYFWATPRQVPSLQHLCRMSVRRVMPTQEV---QELPIPSKLLEFLSYR 420
           689************************999...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
            f +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s++fs
   Q: 135  RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCAFS 223
           5678999***********************************************************9799******************* PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgght 180
           p+++ l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  +g++l ++             g+++
   Q: 224  PDSSILCSVGASKAVFLWNMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFghlfppptpifaGGAND 311
           ***************************.9******************************************************9888** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           + v+s+sf+++g +++s ++d+ v++w + +      + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 312  RWVRSVSFSHDGLHVASLADDKMVRFWRIDED--YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           *****************************888..68899****************************** PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL 60
VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATATCTCC GGCGCCGCCC GCCATTTTGA CTCCTGTGTC TCGTTTGCAG TCGGCGCGTT 60
AGGGGAACTG TCTTCCTCCG CAGGCGCGAG GCTGGGTACA GGGTCTATTG TCTGTGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	97.62	0.00e+00	837.00
IUUC-Apl-003903	Anas platyrhynchos	90.66	0.00e+00	782.00
IUUC-Aca-005214	Anolis carolinensis	77.93	0.00e+00	697.00
IUUC-Ame-011740	Astyanax mexicanus	75.06	0.00e+00	679.00
IUUC-Bta-013475	Bos taurus	97.62	0.00e+00	838.00
IUUC-Cja-019053	Callithrix jacchus	99.05	0.00e+00	867.00
IUUC-Cfa-020103	Canis familiaris	98.57	0.00e+00	843.00
IUUC-Cpo-022438	Cavia porcellus	95.49	0.00e+00	844.00
IUUC-Csa-024062	Chlorocebus sabaeus	99.05	0.00e+00	873.00
IUUC-Cho-024334	Choloepus hoffmanni	84.80	0.00e+00	707.00
IUUC-Cin-025590	Ciona intestinalis	40.15	9.00e-79	286.00
IUUC-Csv-026023	Ciona savignyi	39.81	4.00e-79	288.00
IUUC-Dre-028089	Danio rerio	75.06	0.00e+00	681.00
IUUC-Dno-029436	Dasypus novemcinctus	91.46	0.00e+00	673.00
IUUC-Dor-031107	Dipodomys ordii	90.02	0.00e+00	754.00
IUUC-Ete-032326	Echinops telfairi	93.37	0.00e+00	785.00
IUUC-Eca-033401	Equus caballus	97.15	0.00e+00	831.00
IUUC-Eeu-034520	Erinaceus europaeus	94.06	0.00e+00	837.00
IUUC-Fca-036386	Felis catus	97.62	0.00e+00	837.00
IUUC-Fal-036616	Ficedula albicollis	86.73	0.00e+00	751.00
IUUC-Gmo-039335	Gadus morhua	72.73	5.00e-180	623.00
IUUC-Gga-040856	Gallus gallus	88.60	0.00e+00	790.00
IUUC-Gac-042140	Gasterosteus aculeatus	74.41	0.00e+00	669.00
IUUC-Ggo-044619	Gorilla gorilla	98.81	0.00e+00	868.00
IUUC-Hsa-046300	Homo sapiens	99.29	0.00e+00	871.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	97.15	0.00e+00	858.00
IUUC-Lch-049550	Latimeria chalumnae	80.06	1.00e-170	592.00
IUUC-Loc-051769	Lepisosteus oculatus	77.67	0.00e+00	691.00
IUUC-Laf-054576	Loxodonta africana	96.20	0.00e+00	832.00
IUUC-Mcc-054666	Macaca mulatta	98.47	1.00e-155	541.00
IUUC-Meu-055989	Macropus eugenii	88.00	0.00e+00	643.00
IUUC-Mga-059722	Meleagris gallopavo	88.19	0.00e+00	782.00
IUUC-Mmr-060970	Microcebus murinus	97.15	0.00e+00	833.00
IUUC-Mdo-062249	Monodelphis domestica	79.33	0.00e+00	653.00
IUUC-Mmu-063742	Mus musculus	92.62	0.00e+00	820.00
IUUC-Mpu-066518	Mustela putorius furo	96.91	0.00e+00	857.00
IUUC-Mlu-068063	Myotis lucifugus	95.25	0.00e+00	821.00
IUUC-Nle-069561	Nomascus leucogenys	99.05	0.00e+00	872.00
IUUC-Opr-071158	Ochotona princeps	91.90	0.00e+00	808.00
IUUC-Ont-072542	Oreochromis niloticus	73.47	0.00e+00	662.00
IUUC-Oan-073217	Ornithorhynchus anatinus	91.21	0.00e+00	806.00
IUUC-Ocu-074251	Oryctolagus cuniculus	96.33	0.00e+00	810.00
IUUC-Ola-086549	Oryzias latipes	72.54	0.00e+00	662.00
IUUC-Oga-088382	Otolemur garnettii	97.62	0.00e+00	840.00
IUUC-Oar-090263	Ovis aries	95.72	0.00e+00	838.00
IUUC-Pan-092518	Papio anubis	99.05	0.00e+00	873.00
IUUC-Psi-093512	Pelodiscus sinensis	89.55	0.00e+00	795.00
IUUC-Pma-094324	Petromyzon marinus	58.33	3.00e-136	478.00
IUUC-Pfo-096264	Poecilia formosa	73.24	0.00e+00	666.00
IUUC-Pab-098018	Pongo abelii	97.39	0.00e+00	853.00
IUUC-Pca-101034	Procavia capensis	94.10	0.00e+00	770.00
IUUC-Pva-102862	Pteropus vampyrus	92.87	0.00e+00	767.00
IUUC-Rno-106116	Rattus norvegicus	93.11	0.00e+00	826.00
IUUC-Sha-106952	Sarcophilus harrisii	90.00	0.00e+00	756.00
IUUC-Sar-113211	Sorex araneus	84.59	4.00e-150	523.00
IUUC-Ssc-116440	Sus scrofa	98.10	0.00e+00	839.00
IUUC-Tgu-116675	Taeniopygia guttata	87.47	0.00e+00	755.00
IUUC-Tru-118295	Takifugu rubripes	72.54	0.00e+00	644.00
IUUC-Tsy-118916	Tarsius syrichta	85.04	0.00e+00	709.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.83	0.00e+00	636.00
IUUC-Tbe-127416	Tupaia belangeri	83.54	0.00e+00	679.00
IUUC-Ttr-128185	Tursiops truncatus	97.86	0.00e+00	839.00
IUUC-Xtr-132465	Xenopus tropicalis	82.62	0.00e+00	741.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence