iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012817

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 3

Genbank Nucleotide ID

AY026859

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008441.2	ENSBTAT00000011106.2	ENSBTAP00000011106.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	91.70	4.00e-110	394.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWST VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCGTGCGCC ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA 60
CACCAGCCTG CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

KEGG

bta:282081

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	87.77	4.00e-105	373.00
IUUC-Apl-003607	Anas platyrhynchos	81.22	3.00e-96	343.00
IUUC-Aca-005063	Anolis carolinensis	78.30	1.00e-101	361.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	8.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	55.98	7.00e-69	253.00
IUUC-Bra-017963	Brassica rapa	28.57	2.20e-01	30.40
IUUC-Cja-019605	Callithrix jacchus	90.83	4.00e-111	393.00
IUUC-Cfa-021231	Canis familiaris	90.39	1.00e-106	378.00
IUUC-Cpo-022003	Cavia porcellus	90.83	1.00e-106	378.00
IUUC-Csa-023511	Chlorocebus sabaeus	91.70	2.00e-109	387.00
IUUC-Dre-028536	Danio rerio	58.55	2.00e-74	271.00
IUUC-Dno-029003	Dasypus novemcinctus	87.34	3.00e-108	384.00
IUUC-Eca-034205	Equus caballus	89.39	2.00e-69	254.00
IUUC-Fca-036317	Felis catus	90.31	3.00e-106	377.00
IUUC-Gmo-038777	Gadus morhua	62.96	2.00e-35	140.00
IUUC-Gga-041258	Gallus gallus	81.22	2.00e-96	344.00
IUUC-Gac-041837	Gasterosteus aculeatus	54.94	1.00e-64	238.00
IUUC-Ggo-045620	Gorilla gorilla	91.70	2.00e-109	387.00
IUUC-Hsa-046909	Homo sapiens	91.70	2.00e-109	387.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	93.16	6.00e-111	392.00
IUUC-Lch-049510	Latimeria chalumnae	66.09	2.00e-83	301.00
IUUC-Loc-052863	Lepisosteus oculatus	63.25	4.00e-80	290.00
IUUC-Laf-054136	Loxodonta africana	93.45	2.00e-108	384.00
IUUC-Mcc-055383	Macaca mulatta	91.70	2.00e-109	387.00
IUUC-Meu-056153	Macropus eugenii	87.34	2.00e-109	388.00
IUUC-Mmr-061185	Microcebus murinus	88.65	4.00e-106	376.00
IUUC-Mdo-061819	Monodelphis domestica	88.21	4.00e-110	390.00
IUUC-Mmu-064231	Mus musculus	90.83	6.00e-112	396.00
IUUC-Mpu-066691	Mustela putorius furo	89.96	1.00e-106	378.00
IUUC-Mlu-067673	Myotis lucifugus	90.39	3.00e-113	400.00
IUUC-Ont-072406	Oreochromis niloticus	55.36	1.00e-68	252.00
IUUC-Oan-073249	Ornithorhynchus anatinus	73.36	1.00e-93	335.00
IUUC-Ocu-074935	Oryctolagus cuniculus	86.76	2.00e-31	125.00
IUUC-Ola-087373	Oryzias latipes	46.45	2.00e-47	182.00
IUUC-Oga-088041	Otolemur garnettii	91.27	2.00e-108	384.00
IUUC-Oar-089646	Ovis aries	96.51	7.00e-105	372.00
IUUC-Ptr-091502	Pan troglodytes	91.70	2.00e-109	387.00
IUUC-Pan-091934	Papio anubis	91.70	2.00e-109	387.00
IUUC-Pfo-096412	Poecilia formosa	41.63	2.00e-47	181.00
IUUC-Pab-098554	Pongo abelii	91.70	2.00e-109	387.00
IUUC-Rno-105874	Rattus norvegicus	90.83	4.00e-112	396.00
IUUC-Sha-107151	Sarcophilus harrisii	87.34	4.00e-110	390.00
IUUC-Ssc-115722	Sus scrofa	80.68	2.00e-64	237.00
IUUC-Tgu-117151	Taeniopygia guttata	80.79	2.00e-95	340.00
IUUC-Tru-118428	Takifugu rubripes	52.79	5.00e-67	246.00
IUUC-Tni-120590	Tetraodon nigroviridis	53.65	2.00e-66	244.00
IUUC-Ttr-129065	Tursiops truncatus	96.94	2.00e-110	391.00
IUUC-Xtr-132167	Xenopus tropicalis	65.50	3.00e-82	297.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence