iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048251

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTP01010841

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000025366.1	ENSSTOT00000020054.1	ENSSTOP00000017583.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-98	330.0	250	653

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+         +++++n ++p                                       
   Q: 250  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNldpsttehLFPQATNGKAPlsgrpasssatelsarsdraqacereglcwnggasisrs 338
           7******************************55555555555555555559*********************************99999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 339  leliqnkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 418
           99999999999999************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 419  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 507
           8999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 508  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFA 594
           965.*******9999999*******************************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 595  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 653
           *************************9999********************...********98 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFED 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDQP VRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTG CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCTCAGAAGT GGTGCTGCCT GGAGTGCGCC ACCACCGAGT CTGTATGGGC TTGCCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	96.02	0.00e+00	860.00
IUUC-Apl-003658	Anas platyrhynchos	78.91	0.00e+00	1067.00
IUUC-Aca-005278	Anolis carolinensis	79.34	0.00e+00	1087.00
IUUC-Bta-012911	Bos taurus	90.38	0.00e+00	1149.00
IUUC-Cja-019171	Callithrix jacchus	92.14	0.00e+00	1242.00
IUUC-Cfa-020408	Canis familiaris	92.98	0.00e+00	1198.00
IUUC-Cpo-022233	Cavia porcellus	84.95	0.00e+00	1098.00
IUUC-Csa-024272	Chlorocebus sabaeus	93.25	0.00e+00	1014.00
IUUC-Cho-025051	Choloepus hoffmanni	91.43	0.00e+00	665.00
IUUC-Cin-025587	Ciona intestinalis	46.72	3.00e-108	386.00
IUUC-Dno-029856	Dasypus novemcinctus	90.57	0.00e+00	1199.00
IUUC-Ete-032761	Echinops telfairi	76.52	0.00e+00	871.00
IUUC-Eca-033851	Equus caballus	84.56	0.00e+00	1024.00
IUUC-Fca-035919	Felis catus	95.99	0.00e+00	805.00
IUUC-Fal-037290	Ficedula albicollis	76.98	0.00e+00	944.00
IUUC-Gmo-039249	Gadus morhua	77.67	1.00e-146	513.00
IUUC-Gac-042595	Gasterosteus aculeatus	61.14	0.00e+00	767.00
IUUC-Ggo-044979	Gorilla gorilla	93.75	0.00e+00	1245.00
IUUC-Hsa-046743	Homo sapiens	93.75	0.00e+00	1244.00
IUUC-Lch-050294	Latimeria chalumnae	75.21	0.00e+00	957.00
IUUC-Loc-051961	Lepisosteus oculatus	70.45	0.00e+00	655.00
IUUC-Laf-053819	Loxodonta africana	94.63	0.00e+00	856.00
IUUC-Mcc-055048	Macaca mulatta	93.75	0.00e+00	1242.00
IUUC-Meu-055971	Macropus eugenii	67.77	3.00e-149	521.00
IUUC-Mmr-061253	Microcebus murinus	86.03	9.00e-156	543.00
IUUC-Mdo-062073	Monodelphis domestica	82.64	0.00e+00	1117.00
IUUC-Mmu-064095	Mus musculus	91.72	0.00e+00	1214.00
IUUC-Mpu-066318	Mustela putorius furo	95.44	0.00e+00	880.00
IUUC-Mlu-067090	Myotis lucifugus	89.34	0.00e+00	1165.00
IUUC-Nle-069486	Nomascus leucogenys	94.19	0.00e+00	1251.00
IUUC-Opr-070563	Ochotona princeps	91.27	0.00e+00	1228.00
IUUC-Oan-073245	Ornithorhynchus anatinus	90.00	0.00e+00	631.00
IUUC-Ocu-074851	Oryctolagus cuniculus	92.33	0.00e+00	973.00
IUUC-Ola-086413	Oryzias latipes	58.82	0.00e+00	740.00
IUUC-Oga-088862	Otolemur garnettii	92.30	0.00e+00	1219.00
IUUC-Oar-089462	Ovis aries	91.10	0.00e+00	819.00
IUUC-Ptr-091525	Pan troglodytes	93.94	0.00e+00	1123.00
IUUC-Pan-092363	Papio anubis	94.27	0.00e+00	1199.00
IUUC-Psi-093353	Pelodiscus sinensis	80.80	0.00e+00	1075.00
IUUC-Pma-094155	Petromyzon marinus	60.07	1.00e-83	302.00
IUUC-Pfo-096413	Poecilia formosa	61.71	0.00e+00	788.00
IUUC-Pab-098592	Pongo abelii	93.25	0.00e+00	1015.00
IUUC-Pca-100449	Procavia capensis	89.45	0.00e+00	1189.00
IUUC-Pva-102868	Pteropus vampyrus	91.24	0.00e+00	1184.00
IUUC-Rno-105190	Rattus norvegicus	90.84	0.00e+00	1218.00
IUUC-Sha-107337	Sarcophilus harrisii	82.72	0.00e+00	1099.00
IUUC-Sar-113561	Sorex araneus	94.01	1.00e-94	339.00
IUUC-Ssc-115735	Sus scrofa	92.12	0.00e+00	1176.00
IUUC-Tgu-117025	Taeniopygia guttata	72.10	0.00e+00	871.00
IUUC-Tru-117585	Takifugu rubripes	61.75	0.00e+00	764.00
IUUC-Tsy-118814	Tarsius syrichta	93.61	0.00e+00	1220.00
IUUC-Tni-120600	Tetraodon nigroviridis	61.65	0.00e+00	736.00
IUUC-Xtr-132090	Xenopus tropicalis	70.06	0.00e+00	934.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence