iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074851

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02017968

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000021251.2	ENSOCUT00000030828.2	ENSOCUP00000025555.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-67	227.7	252	573

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++++++  p                                               
   Q: 252  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSTTEHLFPqatngraqlsgkpvggsatelsarshraeacereglcwnggasisrs 340
           7******************************555555555555555555699999*****************99999999999999999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 341  leliqnkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGAA 420
           99999999999999************************************************************.........678999 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 421  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 509
           9999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefp 256
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f 
   Q: 510  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFD 573
           965.*******9999999*******************************997.8889******996 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWRCLECA TTESVWACLK CSHVACGRYI EDHARKHFEE 60
TGHPLAMEVR DLYVFCYLCE DYVLNDNPEG DLKLLTSSLL AVRGQEQDPP VRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAACAGAGA AGAGGAAACC TAACGAATGG CTGTGGAATA ATATGGAAGA AGATGGAAAA 60
AACTTGTTTA ATGGGTAAGA AATAAAAGCA TAGTAATAAA ATGTTATTAA TGGGAACTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	95.54	2.00e-179	622.00
IUUC-Apl-003658	Anas platyrhynchos	76.71	0.00e+00	848.00
IUUC-Aca-005278	Anolis carolinensis	77.74	0.00e+00	875.00
IUUC-Bta-012911	Bos taurus	89.39	0.00e+00	913.00
IUUC-Cja-019171	Callithrix jacchus	92.35	0.00e+00	982.00
IUUC-Cfa-020408	Canis familiaris	90.42	0.00e+00	949.00
IUUC-Cpo-022233	Cavia porcellus	84.48	0.00e+00	869.00
IUUC-Csa-024272	Chlorocebus sabaeus	89.20	0.00e+00	989.00
IUUC-Cho-025051	Choloepus hoffmanni	87.67	5.00e-155	541.00
IUUC-Dre-027577	Danio rerio	57.12	5.00e-167	581.00
IUUC-Dno-029856	Dasypus novemcinctus	88.93	0.00e+00	949.00
IUUC-Ete-032761	Echinops telfairi	79.54	0.00e+00	755.00
IUUC-Eca-033851	Equus caballus	81.53	0.00e+00	833.00
IUUC-Fca-035919	Felis catus	95.10	3.00e-162	564.00
IUUC-Fal-037290	Ficedula albicollis	75.26	0.00e+00	760.00
IUUC-Ggo-044979	Gorilla gorilla	92.39	0.00e+00	982.00
IUUC-Hsa-046743	Homo sapiens	92.21	0.00e+00	978.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	93.21	0.00e+00	1008.00
IUUC-Loc-051961	Lepisosteus oculatus	67.66	0.00e+00	650.00
IUUC-Mcc-055048	Macaca mulatta	92.56	0.00e+00	984.00
IUUC-Meu-055971	Macropus eugenii	66.81	6.00e-148	517.00
IUUC-Mdo-062073	Monodelphis domestica	80.24	0.00e+00	885.00
IUUC-Mmu-064095	Mus musculus	90.94	0.00e+00	979.00
IUUC-Mpu-066318	Mustela putorius furo	95.09	0.00e+00	644.00
IUUC-Mlu-067090	Myotis lucifugus	87.98	0.00e+00	933.00
IUUC-Nle-069486	Nomascus leucogenys	93.08	0.00e+00	988.00
IUUC-Opr-070563	Ochotona princeps	94.78	0.00e+00	1030.00
IUUC-Ont-072103	Oreochromis niloticus	57.49	3.00e-179	621.00
IUUC-Oga-088862	Otolemur garnettii	89.57	0.00e+00	952.00
IUUC-Ptr-091525	Pan troglodytes	92.39	0.00e+00	979.00
IUUC-Pan-092363	Papio anubis	92.56	0.00e+00	980.00
IUUC-Psi-093353	Pelodiscus sinensis	78.97	0.00e+00	860.00
IUUC-Pma-094155	Petromyzon marinus	60.07	2.00e-83	301.00
IUUC-Pab-098592	Pongo abelii	89.20	0.00e+00	986.00
IUUC-Pca-100449	Procavia capensis	87.78	0.00e+00	937.00
IUUC-Pva-102868	Pteropus vampyrus	90.07	0.00e+00	937.00
IUUC-Rno-105190	Rattus norvegicus	90.96	0.00e+00	980.00
IUUC-Sha-107337	Sarcophilus harrisii	79.73	0.00e+00	882.00
IUUC-Sar-113561	Sorex araneus	72.73	2.00e-72	266.00
IUUC-Ssc-115735	Sus scrofa	90.59	0.00e+00	925.00
IUUC-Tgu-117025	Taeniopygia guttata	75.17	0.00e+00	776.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence