iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013039

Ensembl Protein ID

ENSBTAP00000024518.4

UniProt Accession

Q1LZB2; F1MBQ7; Q1LZB2_BOVIN

Genbank Protein ID

AAI16110.1

Protein Name

NCK adaptor protein 1

Genbank Nucleotide ID

DAAA02002998

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018427.4	ENSBTAT00000024518.4	ENSBTAP00000024518.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.70e-47	157.1	192	249

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGd+++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDIMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTI 249
           689**************************************.59*************85 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LNIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGAGCTA CGCGGCGGCA GAGCGGAGGC CTCGTGCCGT AACGGCCATC GCGGCGGCCG 60
TGGCGGCGTC CCTGCCCTCC TCAAGTGAGC TGGCGCCGCC CGGGCTCGGC AGAGGGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

KEGG

bta:536154

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.94	0.00e+00	737.00
IUUC-Ame-011235	Astyanax mexicanus	77.84	9.00e-180	622.00
IUUC-Cja-019546	Callithrix jacchus	98.67	0.00e+00	730.00
IUUC-Cfa-020462	Canis familiaris	99.20	0.00e+00	739.00
IUUC-Cpo-022009	Cavia porcellus	97.88	0.00e+00	732.00
IUUC-Csa-023875	Chlorocebus sabaeus	98.94	0.00e+00	738.00
IUUC-Cho-024368	Choloepus hoffmanni	97.67	0.00e+00	652.00
IUUC-Csv-026046	Ciona savignyi	40.60	4.00e-72	265.00
IUUC-Dre-028407	Danio rerio	76.25	7.00e-177	612.00
IUUC-Dno-029593	Dasypus novemcinctus	98.72	3.00e-174	603.00
IUUC-Dor-030730	Dipodomys ordii	97.44	0.00e+00	641.00
IUUC-Dme-031846	Drosophila melanogaster	42.86	4.00e-91	328.00
IUUC-Ete-032906	Echinops telfairi	97.61	0.00e+00	725.00
IUUC-Eca-033378	Equus caballus	99.09	0.00e+00	640.00
IUUC-Eeu-034743	Erinaceus europaeus	88.33	0.00e+00	674.00
IUUC-Fca-035745	Felis catus	98.94	0.00e+00	779.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.32	2.00e-158	551.00
IUUC-Ggo-045487	Gorilla gorilla	98.94	0.00e+00	738.00
IUUC-Hsa-045902	Homo sapiens	98.94	0.00e+00	738.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	98.67	0.00e+00	737.00
IUUC-Lch-050165	Latimeria chalumnae	82.49	0.00e+00	625.00
IUUC-Loc-052523	Lepisosteus oculatus	78.89	3.00e-179	620.00
IUUC-Laf-053845	Loxodonta africana	98.41	0.00e+00	734.00
IUUC-Meu-056139	Macropus eugenii	91.51	0.00e+00	666.00
IUUC-Mmr-061108	Microcebus murinus	87.00	6.00e-174	603.00
IUUC-Mdo-062258	Monodelphis domestica	94.96	0.00e+00	712.00
IUUC-Mmu-063970	Mus musculus	98.41	0.00e+00	778.00
IUUC-Mpu-066093	Mustela putorius furo	98.67	0.00e+00	736.00
IUUC-Mlu-067193	Myotis lucifugus	98.94	0.00e+00	736.00
IUUC-Nle-069611	Nomascus leucogenys	98.94	0.00e+00	738.00
IUUC-Opr-070984	Ochotona princeps	97.34	2.00e-179	620.00
IUUC-Ont-072241	Oreochromis niloticus	75.38	4.00e-171	593.00
IUUC-Oan-072976	Ornithorhynchus anatinus	89.25	3.00e-167	580.00
IUUC-Ocu-073905	Oryctolagus cuniculus	98.94	0.00e+00	738.00
IUUC-Ola-086513	Oryzias latipes	74.36	1.00e-158	552.00
IUUC-Oga-088588	Otolemur garnettii	98.94	0.00e+00	736.00
IUUC-Oar-089973	Ovis aries	99.73	0.00e+00	740.00
IUUC-Ptr-090968	Pan troglodytes	98.94	0.00e+00	738.00
IUUC-Pan-092840	Papio anubis	99.04	3.00e-175	607.00
IUUC-Pfo-096057	Poecilia formosa	73.72	2.00e-168	585.00
IUUC-Pab-097807	Pongo abelii	99.20	0.00e+00	738.00
IUUC-Pca-100522	Procavia capensis	98.08	2.00e-173	601.00
IUUC-Pva-103083	Pteropus vampyrus	99.20	0.00e+00	738.00
IUUC-Rno-104839	Rattus norvegicus	95.49	0.00e+00	740.00
IUUC-Sha-107294	Sarcophilus harrisii	93.90	0.00e+00	704.00
IUUC-Sar-113675	Sorex araneus	97.35	0.00e+00	723.00
IUUC-Ssc-116442	Sus scrofa	98.14	0.00e+00	771.00
IUUC-Tru-118058	Takifugu rubripes	74.05	6.00e-168	583.00
IUUC-Tsy-119184	Tarsius syrichta	91.85	0.00e+00	630.00
IUUC-Tni-119974	Tetraodon nigroviridis	73.72	6.00e-156	543.00
IUUC-Ttr-129155	Tursiops truncatus	96.82	0.00e+00	732.00
IUUC-Vpa-130344	Vicugna pacos	99.47	0.00e+00	739.00
IUUC-Xtr-132372	Xenopus tropicalis	87.50	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence