iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.50e-06	29.5	15	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC++ f d p++ +CgH f++ Cl  +w    + +   ++C  C+
   Q: 15   CPICMNYFLD-PVTIDCGHSFCRPCLyLNW----QDTAVLAQCSECK 56
           **********.999************99**....7778888888885 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MNSGILQVFQ RALTCPICMN YFLDPVTIDC GHSFCRPCLY LNWQDTAVLA QCSECKKTTR 60
QRNLNTDICL KNMAFIARKA SLRQFLSSEE QICGMHRETK KMFCEVDKSL LCLPCSNSQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGGAATG AGCTCCTGAT CTTGGGGAGT ACTTAAAAGA ATTTTTTCTT GGAAGAATTA 60
CTGCAGGAAA CATTCATAGA ACCTTGGGGT GAGTGCAACT TCTATGGAGA AAATTATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding

KEGG

hsa:84767

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019533	Callithrix jacchus	76.60	0.00e+00	685.00
IUUC-Csa-023811	Chlorocebus sabaeus	88.86	0.00e+00	736.00
IUUC-Ggo-045129	Gorilla gorilla	87.35	0.00e+00	700.00
IUUC-Mcc-054894	Macaca mulatta	90.04	0.00e+00	831.00
IUUC-Nle-069130	Nomascus leucogenys	90.29	0.00e+00	759.00
IUUC-Ocu-074184	Oryctolagus cuniculus	63.27	5.00e-170	590.00
IUUC-Ptr-090618	Pan troglodytes	92.70	0.00e+00	820.00
IUUC-Pan-092648	Papio anubis	90.93	0.00e+00	805.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence