iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045350

Ensembl Protein ID

ENSGGOP00000017030.1

UniProt Accession

G3RML6; G3RML6_GORGO

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Gene Name

WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000027398.1	ENSGGOT00000024082.1	ENSGGOP00000017030.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-06	28.5	184	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+ ++   +   ll s+s+D+t+++W++r+g++l+
   Q: 184  GHTEFVNYISMlpTQpELLPSSSGDCTLRLWEYRSGRQLH 223
           799999999988633699******************9986 PP

Organism

Gorilla gorilla

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

KADSAGLALC GQKLVVQGSS RFQTTSTASS DDDSLFIYDC SAENKSQENK GEDEPTLVQG 60
SGAILSTFSK SGSCFALTDD SKCLILFCTK PWQCLSVRTM TRRCTDLTFT ASEEKVLVAD 120

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Nucleotide Sequence
(Fasta)

AAGGCAGACT CTGCGGGGCT GGCGTTGTGC GGGCAGAAGC TGGTGGTGCA GGGGAGCAGC 60
CGGTTCCAGA CCACCTCCAC TGCAAGCAGT GACGATGACA GCCTCTTCAT CTATGACTGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Gene Ontology

GO:0036265--P:RNA (guanine-N7)-methylation

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence