iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132113

Ensembl Protein ID

ENSXETP00000043392.1

UniProt Accession

A4IIN1; A4IIN1_XENTR

Genbank Protein ID

AAI36088.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAMC01065803

Gene Name

siah2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000020096.1	ENSXETT00000043392.1	ENSXETP00000043392.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.02	2.00e-148	522.00	IUUC-Hsa-046179
E3 activity/RING/RING	81.48	2.00e-148	521.00	IUUC-Mmu-063206
E3 activity/RING/RING	81.79	2.00e-148	521.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGPC ASKPCGKQKQ PPPPPPPHAA SLSLPATISG GPGSSAPPPP AAAAAAITGP 60
LSQQHQELTS LFECPVCFDY VLPPILQCQA GHLVCNQCRQ KLSCCPTCRA SLTPSIRNLA 120

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Nucleotide Sequence
(Fasta)

ATGAGCCGCC CGTCCTCTGC CGGACCCTGC GCTAGCAAAC CGTGTGGCAA GCAAAAGCAG 60
CCGCCGCCAC CACCGCCACC CCACGCTGCG TCTCTGTCGC TGCCTGCCAC GATTTCCGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:100124319

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	94.57	2.00e-148	518.00
IUUC-Ame-011678	Astyanax mexicanus	90.12	1.00e-138	486.00
IUUC-Bta-012750	Bos taurus	94.90	8.00e-148	516.00
IUUC-Cja-019800	Callithrix jacchus	83.64	5.00e-149	520.00
IUUC-Cfa-020505	Canis familiaris	94.90	2.00e-147	514.00
IUUC-Cpo-021394	Cavia porcellus	81.76	5.00e-151	526.00
IUUC-Csa-023374	Chlorocebus sabaeus	83.64	5.00e-149	520.00
IUUC-Cho-024933	Choloepus hoffmanni	95.29	6.00e-148	516.00
IUUC-Dre-027711	Danio rerio	90.12	4.00e-139	486.00
IUUC-Dno-029260	Dasypus novemcinctus	95.51	4.00e-143	500.00
IUUC-Dor-030489	Dipodomys ordii	91.89	3.00e-104	370.00
IUUC-Ete-032946	Echinops telfairi	82.72	8.00e-151	525.00
IUUC-Eca-033546	Equus caballus	94.27	2.00e-151	527.00
IUUC-Eeu-034861	Erinaceus europaeus	90.73	2.00e-142	498.00
IUUC-Fal-037160	Ficedula albicollis	84.46	3.00e-128	450.00
IUUC-Gmo-039091	Gadus morhua	87.89	6.00e-138	483.00
IUUC-Gga-040252	Gallus gallus	84.64	3.00e-149	520.00
IUUC-Gac-041673	Gasterosteus aculeatus	88.14	1.00e-137	482.00
IUUC-Ggo-044618	Gorilla gorilla	83.64	5.00e-149	520.00
IUUC-Hsa-046179	Homo sapiens	83.64	5.00e-149	520.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	93.02	4.00e-146	509.00
IUUC-Lch-049496	Latimeria chalumnae	83.12	2.00e-153	534.00
IUUC-Loc-052107	Lepisosteus oculatus	90.80	1.00e-138	485.00
IUUC-Laf-054257	Loxodonta africana	94.21	2.00e-147	514.00
IUUC-Mcc-055023	Macaca mulatta	83.64	5.00e-149	520.00
IUUC-Meu-055922	Macropus eugenii	94.12	5.00e-145	506.00
IUUC-Mga-060070	Meleagris gallopavo	92.19	4.00e-142	496.00
IUUC-Mmr-061494	Microcebus murinus	83.64	5.00e-149	520.00
IUUC-Mdo-061971	Monodelphis domestica	94.90	3.00e-147	514.00
IUUC-Mmu-063206	Mus musculus	82.10	3.00e-148	517.00
IUUC-Mpu-066597	Mustela putorius furo	83.95	5.00e-149	520.00
IUUC-Mlu-067199	Myotis lucifugus	94.90	2.00e-147	514.00
IUUC-Nle-069342	Nomascus leucogenys	83.64	5.00e-149	520.00
IUUC-Ont-071906	Oreochromis niloticus	87.89	5.00e-139	486.00
IUUC-Ocu-073950	Oryctolagus cuniculus	94.21	7.00e-149	519.00
IUUC-Oga-089154	Otolemur garnettii	83.64	5.00e-149	520.00
IUUC-Oar-089446	Ovis aries	93.13	3.00e-149	520.00
IUUC-Ptr-091088	Pan troglodytes	83.64	5.00e-149	520.00
IUUC-Psi-093079	Pelodiscus sinensis	95.00	4.00e-150	523.00
IUUC-Pfo-097007	Poecilia formosa	83.40	4.00e-131	460.00
IUUC-Pab-098092	Pongo abelii	83.64	5.00e-149	520.00
IUUC-Pca-100328	Procavia capensis	81.48	8.00e-144	502.00
IUUC-Pva-102368	Pteropus vampyrus	97.32	6.00e-63	233.00
IUUC-Rno-105477	Rattus norvegicus	82.10	3.00e-148	517.00
IUUC-Sha-107630	Sarcophilus harrisii	94.62	1.00e-149	521.00
IUUC-Ssc-116441	Sus scrofa	83.33	1.00e-148	518.00
IUUC-Tru-118004	Takifugu rubripes	85.16	1.00e-133	468.00
IUUC-Tsy-119548	Tarsius syrichta	86.57	3.00e-66	244.00
IUUC-Tni-120846	Tetraodon nigroviridis	87.75	6.00e-136	476.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence