iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000013092.5	ENSGALT00000086623.1	ENSGALP00000063411.1
ENSGALG00000013092.5	ENSGALT00000021374.4	ENSGALP00000021343.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-27	95.3	263	297
UBD/Beta-Prp	1.80e-42	145.9	13	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtll.vsGsdDgtikvWDlrtg 33
           gH ++++c++f +d+ l +sGs Dgt+++W ++ g
   Q: 263  GHFGPIHCVRFsPDGELyASGSEDGTLRLWQTTVG 297
           799*********997776************98765 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkf...spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           h   ++ +++f   +p + +l+++++dg+  + + +tg+ + ++ gh+++v+  ++++d+   +t++ D t+kvwd  +g+ ++tl  h
   Q: 13   HTR-PVVDLAFsgvTPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELITLA-H 99
           444.4555888788899999*******************************************************************.* PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           ++ v s++f +++++l++G++d+ +r++dl++ +   ++ sgh++ +  + +++d++ + s ++D+tvrlWd +t++ ++ l      s
   Q: 100  KHIVKSVDFTQDSNYLLTGGQDKLLRIYDLSKPEAEPDVVSGHTSGIKKALWSSDDKQILS-ADDKTVRLWDRSTMTEVKALN--VAMS 185
           ******************************************************9987766.69*********6666666663..4666 PP
   S: 183  vyslsfdsng........................................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs 231
           v s+++ ++g                                        ++lv+g++d ++  +d+ tge +++++gh  ++ +vrfs
   Q: 186  VSSMEYVPEGqilvitygktiafhsaetleqiksfeapatinsaslhpekECLVAGGEDFKLYKYDYNTGEELESYKGHFGPIHCVRFS 274
           66666555555555555555555555555555555555555555555555*************************************** PP
   S: 232  pnderlvsgssDgsiriWdlrsgdl 256
           p++e+++sgs+Dg++r+W ++ g++
   Q: 275  PDGELYASGSEDGTLRLWQTTVGKT 299
           ******************8776665 PP

Organism

Gallus gallus

Functional Description
(View)

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex (By similarity).

Protein Sequence
(Fasta)

MAMRQTPLTC SGHTRPVVDL AFSGVTPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG 60
AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELITLAHK HIVKSVDFTQ DSNYLLTGGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCGCTTC CGCTGCTGTC ATTTCCGCCG TTGCCGCCAA CACCGCGGTC GCCGTTTCCT 60
ACCCGGCTGG AGGATAGCCG CGTCCCTGCC CAGCTCCCTG CGCGTCCCGA GCTCAGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0032797--C:SMN complex
GO:0034719--C:SMN-Sm protein complex
GO:0005102--F:receptor binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0000387--P:spliceosomal snRNP assembly

KEGG

gga:418175

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000668	Aegilops tauschii	49.48	6.00e-75	273.00
IUUC-Aml-002091	Ailuropoda melanoleuca	85.16	1.00e-166	578.00
IUUC-Atr-002571	Amborella trichopoda	52.23	2.00e-78	285.00
IUUC-Apl-003327	Anas platyrhynchos	97.78	6.00e-160	556.00
IUUC-Aca-005324	Anolis carolinensis	92.00	3.00e-178	617.00
IUUC-Aly-006452	Arabidopsis lyrata	49.48	1.00e-76	279.00
IUUC-Ath-006646	Arabidopsis thaliana	49.48	1.00e-76	279.00
IUUC-Acl-008014	Aspergillus clavatus	41.67	8.00e-50	190.00
IUUC-Afl-008701	Aspergillus flavus	40.14	3.00e-34	139.00
IUUC-Afu-008942	Aspergillus fumigatus	30.93	1.00e-34	140.00
IUUC-Ani-009394	Aspergillus nidulans	40.96	5.00e-50	191.00
IUUC-Ang-009593	Aspergillus niger	38.31	9.00e-36	144.00
IUUC-Aor-010206	Aspergillus oryzae	42.69	1.00e-50	193.00
IUUC-Ame-011328	Astyanax mexicanus	81.67	5.00e-141	493.00
IUUC-Bgr-012308	Blumeria graminis	41.86	1.00e-58	219.00
IUUC-Bta-013429	Bos taurus	88.57	3.00e-167	580.00
IUUC-Bci-013803	Botrytis cinerea	41.21	3.00e-55	208.00
IUUC-Bdi-014996	Brachypodium distachyon	48.95	5.00e-75	274.00
IUUC-Bol-016595	Brassica oleracea	50.00	2.00e-78	285.00
IUUC-Bra-017775	Brassica rapa	48.81	4.00e-77	283.00
IUUC-Cja-018740	Callithrix jacchus	84.30	2.00e-162	564.00
IUUC-Cfa-021145	Canis familiaris	88.29	1.00e-167	582.00
IUUC-Cpo-022373	Cavia porcellus	88.29	3.00e-167	580.00
IUUC-Cre-022806	Chlamydomonas reinhardtii	44.52	2.00e-61	229.00
IUUC-Csa-023098	Chlorocebus sabaeus	87.43	8.00e-165	572.00
IUUC-Cho-024856	Choloepus hoffmanni	80.57	3.00e-145	507.00
IUUC-Cin-025541	Ciona intestinalis	59.41	5.00e-106	377.00
IUUC-Csv-026287	Ciona savignyi	58.48	7.00e-96	343.00
IUUC-Cgl-026513	Colletotrichum gloeosporioides	41.39	7.00e-54	204.00
IUUC-Cne-026869	Cryptococcus neoformans	47.15	9.00e-70	256.00
IUUC-Dre-028457	Danio rerio	74.64	7.00e-144	503.00
IUUC-Dno-029213	Dasypus novemcinctus	88.29	1.00e-169	588.00
IUUC-Dse-031350	Dothistroma septosporum	41.07	2.00e-51	196.00
IUUC-Dme-031857	Drosophila melanogaster	62.21	4.00e-106	377.00
IUUC-Ete-032558	Echinops telfairi	80.62	6.00e-111	392.00
IUUC-Eca-033934	Equus caballus	89.14	6.00e-168	583.00
IUUC-Eeu-034650	Erinaceus europaeus	75.43	6.00e-146	509.00
IUUC-Fca-035909	Felis catus	88.29	4.00e-168	583.00
IUUC-Fal-036706	Ficedula albicollis	98.09	5.00e-156	543.00
IUUC-Fox-037780	Fusarium oxysporum	42.26	4.00e-53	201.00
IUUC-Fso-038197	Fusarium solani	42.39	7.00e-56	210.00
IUUC-Gmo-039707	Gadus morhua	77.35	2.00e-131	461.00
IUUC-Ggr-040054	Gaeumannomyces graminis	40.60	2.00e-55	209.00
IUUC-Gac-041876	Gasterosteus aculeatus	72.57	5.00e-137	480.00
IUUC-Gma-044014	Glycine max	51.55	3.00e-78	285.00
IUUC-Ggo-044583	Gorilla gorilla	81.48	4.00e-151	526.00
IUUC-Hsa-046553	Homo sapiens	84.02	6.00e-164	569.00
IUUC-Hvu-047544	Hordeum vulgare	50.00	5.00e-77	280.00
IUUC-Itr-047980	Ictidomys tridecemlineatus	88.57	6.00e-170	589.00
IUUC-Lch-050078	Latimeria chalumnae	80.63	2.00e-153	535.00
IUUC-Lpe-051246	Leersia perrieri	50.00	1.00e-77	283.00
IUUC-Loc-052598	Lepisosteus oculatus	77.21	5.00e-147	513.00
IUUC-Lma-053226	Leptosphaeria maculans	45.40	2.00e-57	215.00
IUUC-Laf-054053	Loxodonta africana	88.29	3.00e-169	587.00
IUUC-Mcc-054652	Macaca mulatta	84.34	1.00e-163	568.00
IUUC-Mor-057256	Magnaporthe oryzae	39.17	2.00e-53	202.00
IUUC-Mpo-057303	Magnaporthe poae	40.36	1.00e-55	209.00
IUUC-Mtr-058421	Medicago truncatula	51.20	3.00e-78	284.00
IUUC-Mla-059073	Melampsora laricipopulina	46.06	8.00e-65	240.00
IUUC-Mga-059664	Meleagris gallopavo	99.72	0.00e+00	644.00
IUUC-Mvi-060534	Microbotryum violaceum	35.88	3.00e-41	162.00
IUUC-Mmr-061044	Microcebus murinus	89.23	5.00e-161	560.00
IUUC-Mdo-063019	Monodelphis domestica	88.00	2.00e-168	584.00
IUUC-Mmu-064092	Mus musculus	89.43	5.00e-168	583.00
IUUC-Mac-065143	Musa acuminata	51.72	3.00e-77	281.00
IUUC-Mpu-066557	Mustela putorius furo	88.57	6.00e-170	589.00
IUUC-Mlu-068179	Myotis lucifugus	88.29	6.00e-169	586.00
IUUC-Nfi-068553	Neosartorya fischeri	41.67	3.00e-49	188.00
IUUC-Ncr-068934	Neurospora crassa	39.71	8.00e-50	190.00
IUUC-Nle-069482	Nomascus leucogenys	83.75	6.00e-163	566.00
IUUC-Opr-071055	Ochotona princeps	69.14	5.00e-117	413.00
IUUC-Ont-072663	Oreochromis niloticus	75.07	1.00e-137	482.00
IUUC-Ocu-074942	Oryctolagus cuniculus	88.86	1.00e-167	582.00
IUUC-Oba-075160	Oryza barthii	50.00	8.00e-78	283.00
IUUC-Obr-076864	Oryza brachyantha	50.00	1.00e-77	283.00
IUUC-Ogl-077076	Oryza glaberrima	50.00	1.00e-77	283.00
IUUC-Ogu-078591	Oryza glumaepatula	50.00	8.00e-78	283.00
IUUC-Oin-079631	Oryza indica	48.97	4.00e-76	277.00
IUUC-Ome-081693	Oryza meridionalis	48.62	9.00e-75	273.00
IUUC-Oni-082190	Oryza nivara	50.34	6.00e-78	283.00
IUUC-Opu-084163	Oryza punctata	50.00	7.00e-78	283.00
IUUC-Oru-084730	Oryza rufipogon	50.00	8.00e-78	283.00
IUUC-Osa-086010	Oryza sativa	50.00	7.00e-78	283.00
IUUC-Ola-086704	Oryzias latipes	74.93	1.00e-144	505.00
IUUC-Olu-087796	Ostreococcus lucimarinus	52.04	4.00e-80	290.00
IUUC-Oga-088932	Otolemur garnettii	67.51	9.00e-113	399.00
IUUC-Oar-090398	Ovis aries	88.86	1.00e-167	582.00
IUUC-Ptr-091202	Pan troglodytes	87.14	1.00e-166	578.00
IUUC-Pan-091948	Papio anubis	87.71	1.00e-166	578.00
IUUC-Psi-093863	Pelodiscus sinensis	91.02	3.00e-159	553.00
IUUC-Pma-094255	Petromyzon marinus	79.29	5.00e-141	493.00
IUUC-Pno-095075	Phaeosphaeria nodorum	46.77	1.00e-58	219.00
IUUC-Ppa-095206	Physcomitrella patens	49.83	4.00e-82	297.00
IUUC-Pfo-096438	Poecilia formosa	75.78	3.00e-144	503.00
IUUC-Pab-097994	Pongo abelii	86.86	3.00e-166	577.00
IUUC-Pop-099172	Populus trichocarpa	50.69	2.00e-77	282.00
IUUC-Pca-100761	Procavia capensis	79.38	5.00e-139	486.00
IUUC-Ppe-102035	Prunus persica	51.55	6.00e-76	277.00
IUUC-Pva-102794	Pteropus vampyrus	80.57	2.00e-149	521.00
IUUC-Pgr-103581	Puccinia graminis	47.78	6.00e-66	243.00
IUUC-Ptt-103862	Puccinia triticina	47.57	3.00e-63	234.00
IUUC-Pte-104245	Pyrenophora teres	47.10	9.00e-60	223.00
IUUC-Pyt-104537	Pyrenophora triticirepentis	47.10	9.00e-60	223.00
IUUC-Rno-105712	Rattus norvegicus	89.14	1.00e-167	582.00
IUUC-Sha-107568	Sarcophilus harrisii	87.71	2.00e-168	584.00
IUUC-Ssl-108655	Sclerotinia sclerotiorum	40.35	3.00e-53	202.00
IUUC-Smo-108784	Selaginella moellendorffii	53.42	4.00e-83	301.00
IUUC-Sit-109807	Setaria italica	51.72	1.00e-78	287.00
IUUC-Sly-111555	Solanum lycopersicum	50.00	2.00e-76	279.00
IUUC-Stu-111953	Solanum tuberosum	49.31	9.00e-76	276.00
IUUC-Sbi-114290	Sorghum bicolor	51.38	7.00e-79	286.00
IUUC-Sre-115008	Sporisorium reilianum	43.71	2.00e-62	232.00
IUUC-Ssc-116392	Sus scrofa	84.85	2.00e-163	567.00
IUUC-Tgu-116835	Taeniopygia guttata	97.78	2.00e-157	547.00
IUUC-Tru-117558	Takifugu rubripes	74.72	9.00e-144	502.00
IUUC-Tsy-119522	Tarsius syrichta	85.14	3.00e-155	540.00
IUUC-Tni-120330	Tetraodon nigroviridis	80.65	4.00e-135	473.00
IUUC-Tca-121759	Theobroma cacao	52.23	9.00e-78	283.00
IUUC-Tre-122163	Trichoderma reesei	42.69	3.00e-54	204.00
IUUC-Tvi-122609	Trichoderma virens	44.14	2.00e-55	209.00
IUUC-Tae-123053	Triticum aestivum	49.66	2.00e-76	278.00
IUUC-Tur-126808	Triticum urartu	46.51	9.00e-62	229.00
IUUC-Tme-127137	Tuber melanosporum	47.88	4.00e-69	254.00
IUUC-Ttr-128202	Tursiops truncatus	88.29	6.00e-166	576.00
IUUC-Uma-129433	Ustilago maydis	43.71	4.00e-61	227.00
IUUC-Vda-129675	Verticillium dahliae	38.94	5.00e-53	201.00
IUUC-Vpa-130382	Vicugna pacos	88.86	1.00e-167	582.00
IUUC-Vvi-130921	Vitis vinifera	51.89	2.00e-79	288.00
IUUC-Xtr-132648	Xenopus tropicalis	70.79	1.00e-131	462.00
IUUC-Xma-133969	Xiphophorus maculatus	71.79	2.00e-135	474.00
IUUC-Yli-134670	Yarrowia lipolytica	36.13	2.00e-45	175.00
IUUC-Zma-135878	Zea mays	51.38	4.00e-79	287.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence