iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132002

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AAMC01025501

Gene Name

nae1; LOC100145030

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000011245.3	ENSXETT00000024562.3	ENSXETP00000024562.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	9.20e-116	387.6	12	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t+vD++ v+ ++++++F++ +e++gk++A++++e l+eln+dv 
   Q: 12   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIVDGNVVTGEDVGNNFFLTRESIGKNRAQTSMELLQELNDDVT 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ es+++l e+++ Ff+kf++V++++ ++++ +++++ +++ ++pl+ ++t+G++G++r+++k++t+++s++d   +++++ +Pf+
   Q: 101  GNFVPESPEQLLEKDPsFFCKFTIVITTQLPESTLLRLAETLWDSNIPLLVCRTYGFVGYMRIVVKEHTVIESHPDnalEDLRLGQPFP 189
           ***************************************************************************************** PP
   S: 175  tlket.........pnaaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+         +++++++++w+ +++k+l+++++e+ ++ +++++eke+++d++++++ +      edeenfeeai+++++a++ t
   Q: 190  ELREHlqsydldhmERKDHSHTPWIIVVAKFLDKWRSENGGQMPKSYKEKESFRDLIRQGILKnengvpEDEENFEEAIKNVNTALNIT 278
           *****65555555555***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
             +s ++++l++++c ++t ++++fw+                                                              
   Q: 279  KVPSsVEEILNDDRCTNLTHQSTSFWIlaravkefmtvegkgnlplrgtipdmiadsdkfiklqniyrekakkdasavescvskllqsv 367
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         fc n + l+v            ++++kd +v+ ++++     lyl+lra++rf+k+ gr+pg  +++ + d+  +
   Q: 368  grppesisereirLFCRNCAFLRVVrcrsleeeyglDTAKKDDIVSLMENQdneivLYLMLRAVDRFQKQLGRYPGIYNYQIEGDIgkL 456
           **********9997777777777555666666666677777777777776677778********************9999999996556 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            ++++ ++    +++g++  ++d++i+e++++++++ +t+++++gG+aaqE+iK+++++f+ ++n+f+++a+
   Q: 457  KSCLNGLL----QEYGLSLTVKDEYIQEFCRYGAAEPHTVASFLGGAAAQEAIKIITKQFVIFNNTFIYNAM 524
           66666666....*********************************************************986 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQAVHIKEQ KYDRQLRLWG DHGQEALESA HVCLINATAT GTEILKNLVL PGIGSFTIVD 60
GNVVTGEDVG NNFFLTRESI GKNRAQTSME LLQELNDDVT GNFVPESPEQ LLEKDPSFFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATGAGCGC CCTCTAGTGG CAGGAAGCTG CGACATTCAG TTCCGGGTCA CAACCATGGC 60
GCAGGCTGTA CACATAAAGG AACAGAAGTA TGACAGGCAG CTCAGGTACA TTATATCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

xtr:100145030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.94	2.00e-124	438.00
IUUC-Aml-002333	Ailuropoda melanoleuca	78.83	0.00e+00	904.00
IUUC-Atr-002644	Amborella trichopoda	40.85	1.00e-113	402.00
IUUC-Apl-003446	Anas platyrhynchos	75.92	0.00e+00	840.00
IUUC-Aca-004450	Anolis carolinensis	74.10	0.00e+00	857.00
IUUC-Aly-006187	Arabidopsis lyrata	41.41	4.00e-127	447.00
IUUC-Ath-007600	Arabidopsis thaliana	41.98	1.00e-127	449.00
IUUC-Ago-007900	Ashbya gossypii	26.84	4.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	36.58	3.00e-88	318.00
IUUC-Afl-008529	Aspergillus flavus	36.59	4.00e-89	322.00
IUUC-Afu-009071	Aspergillus fumigatus	35.44	4.00e-87	315.00
IUUC-Ani-009443	Aspergillus nidulans	35.22	6.00e-83	301.00
IUUC-Ang-009669	Aspergillus niger	34.05	5.00e-84	305.00
IUUC-Aor-009914	Aspergillus oryzae	35.91	6.00e-86	311.00
IUUC-Ate-010450	Aspergillus terreus	35.61	2.00e-87	316.00
IUUC-Ame-011183	Astyanax mexicanus	71.10	0.00e+00	813.00
IUUC-Bgr-012111	Blumeria graminis	33.58	4.00e-66	245.00
IUUC-Bta-012583	Bos taurus	78.75	0.00e+00	902.00
IUUC-Bci-013892	Botrytis cinerea	35.29	5.00e-72	265.00
IUUC-Bdi-014592	Brachypodium distachyon	43.50	3.00e-126	445.00
IUUC-Bol-016399	Brassica oleracea	40.46	9.00e-125	440.00
IUUC-Bra-017506	Brassica rapa	40.76	1.00e-122	432.00
IUUC-Cel-018456	Caenorhabditis elegans	35.32	1.00e-91	330.00
IUUC-Cja-020007	Callithrix jacchus	78.30	0.00e+00	900.00
IUUC-Cfa-020324	Canis familiaris	78.94	0.00e+00	905.00
IUUC-Cpo-022248	Cavia porcellus	52.85	1.00e-154	539.00
IUUC-Csa-023149	Chlorocebus sabaeus	74.52	0.00e+00	763.00
IUUC-Cho-024537	Choloepus hoffmanni	67.03	0.00e+00	656.00
IUUC-Cin-025763	Ciona intestinalis	50.47	5.00e-159	553.00
IUUC-Csv-026113	Ciona savignyi	48.52	1.00e-150	526.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	33.39	1.00e-66	247.00
IUUC-Cne-026884	Cryptococcus neoformans	31.05	1.00e-77	283.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.69	5.00e-19	89.00
IUUC-Dre-028140	Danio rerio	71.86	0.00e+00	825.00
IUUC-Dno-030033	Dasypus novemcinctus	78.60	0.00e+00	799.00
IUUC-Dor-030513	Dipodomys ordii	54.31	1.00e-88	320.00
IUUC-Dse-031536	Dothistroma septosporum	35.12	2.00e-87	316.00
IUUC-Dme-031683	Drosophila melanogaster	45.95	6.00e-130	457.00
IUUC-Ete-032420	Echinops telfairi	67.64	0.00e+00	743.00
IUUC-Eca-033992	Equus caballus	77.75	0.00e+00	755.00
IUUC-Eeu-034713	Erinaceus europaeus	63.39	5.00e-94	338.00
IUUC-Fca-036548	Felis catus	77.99	0.00e+00	893.00
IUUC-Fal-037600	Ficedula albicollis	74.71	0.00e+00	825.00
IUUC-Fox-038037	Fusarium oxysporum	32.59	2.00e-74	273.00
IUUC-Fso-038387	Fusarium solani	33.89	7.00e-77	281.00
IUUC-Gmo-038562	Gadus morhua	69.17	0.00e+00	799.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.54	1.00e-70	260.00
IUUC-Gga-041129	Gallus gallus	75.51	0.00e+00	847.00
IUUC-Gac-042558	Gasterosteus aculeatus	70.65	0.00e+00	811.00
IUUC-Gma-043610	Glycine max	41.25	1.00e-121	429.00
IUUC-Ggo-045611	Gorilla gorilla	78.30	0.00e+00	901.00
IUUC-Hsa-046563	Homo sapiens	78.75	0.00e+00	906.00
IUUC-Hvu-047790	Hordeum vulgare	38.96	2.00e-77	283.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	78.94	0.00e+00	902.00
IUUC-Kpa-049309	Komagataella pastoris	37.07	3.00e-83	301.00
IUUC-Lch-050038	Latimeria chalumnae	74.00	0.00e+00	837.00
IUUC-Lpe-051535	Leersia perrieri	42.45	2.00e-111	396.00
IUUC-Loc-051917	Lepisosteus oculatus	68.96	0.00e+00	763.00
IUUC-Lma-053112	Leptosphaeria maculans	35.62	4.00e-86	311.00
IUUC-Laf-053690	Loxodonta africana	78.09	0.00e+00	901.00
IUUC-Mcc-055117	Macaca mulatta	77.02	0.00e+00	887.00
IUUC-Meu-056761	Macropus eugenii	65.78	0.00e+00	713.00
IUUC-Mor-057230	Magnaporthe oryzae	34.12	9.00e-79	287.00
IUUC-Mpo-057514	Magnaporthe poae	32.05	3.00e-69	256.00
IUUC-Mtr-058551	Medicago truncatula	41.05	1.00e-117	416.00
IUUC-Mla-059183	Melampsora laricipopulina	36.58	2.00e-96	346.00
IUUC-Mga-060144	Meleagris gallopavo	74.81	0.00e+00	828.00
IUUC-Mvi-060221	Microbotryum violaceum	34.20	3.00e-77	282.00
IUUC-Mmr-061325	Microcebus murinus	76.98	0.00e+00	885.00
IUUC-Mdo-062532	Monodelphis domestica	78.33	0.00e+00	898.00
IUUC-Mmu-063956	Mus musculus	78.84	0.00e+00	909.00
IUUC-Mac-064521	Musa acuminata	41.54	7.00e-124	437.00
IUUC-Mpu-066716	Mustela putorius furo	78.18	0.00e+00	846.00
IUUC-Mlu-067459	Myotis lucifugus	78.18	0.00e+00	897.00
IUUC-Nfi-068245	Neosartorya fischeri	36.17	1.00e-87	317.00
IUUC-Ncr-068910	Neurospora crassa	34.67	3.00e-79	288.00
IUUC-Nle-070034	Nomascus leucogenys	76.19	0.00e+00	870.00
IUUC-Opr-070552	Ochotona princeps	71.26	0.00e+00	736.00
IUUC-Ont-071426	Oreochromis niloticus	71.48	0.00e+00	829.00
IUUC-Oan-073389	Ornithorhynchus anatinus	74.83	0.00e+00	702.00
IUUC-Ocu-074911	Oryctolagus cuniculus	78.94	0.00e+00	906.00
IUUC-Oba-075437	Oryza barthii	43.16	7.00e-116	410.00
IUUC-Obr-076684	Oryza brachyantha	43.32	1.00e-111	396.00
IUUC-Ogl-077170	Oryza glaberrima	43.16	7.00e-116	410.00
IUUC-Ogu-078844	Oryza glumaepatula	43.34	4.00e-109	388.00
IUUC-Oin-079105	Oryza indica	43.16	3.00e-115	408.00
IUUC-Olo-080943	Oryza longistaminata	40.48	1.00e-103	370.00
IUUC-Oni-082891	Oryza nivara	40.30	5.00e-109	387.00
IUUC-Opu-083457	Oryza punctata	42.97	2.00e-114	405.00
IUUC-Oru-084960	Oryza rufipogon	41.65	2.00e-104	372.00
IUUC-Osa-085358	Oryza sativa	43.35	6.00e-116	410.00
IUUC-Ola-086420	Oryzias latipes	70.51	4.00e-167	580.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.04	4.00e-60	225.00
IUUC-Oga-088810	Otolemur garnettii	79.13	0.00e+00	904.00
IUUC-Oar-089196	Ovis aries	78.30	0.00e+00	899.00
IUUC-Ptr-090617	Pan troglodytes	78.75	0.00e+00	905.00
IUUC-Pan-092761	Papio anubis	78.94	0.00e+00	909.00
IUUC-Psi-093191	Pelodiscus sinensis	77.95	0.00e+00	881.00
IUUC-Pma-094380	Petromyzon marinus	64.10	0.00e+00	686.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.33	2.00e-74	274.00
IUUC-Ppa-095798	Physcomitrella patens	41.93	7.00e-127	447.00
IUUC-Pfo-096467	Poecilia formosa	71.83	0.00e+00	820.00
IUUC-Pab-098255	Pongo abelii	78.26	0.00e+00	751.00
IUUC-Pop-099722	Populus trichocarpa	40.50	6.00e-124	437.00
IUUC-Pca-100807	Procavia capensis	67.55	6.00e-104	370.00
IUUC-Ppe-101280	Prunus persica	39.92	4.00e-122	431.00
IUUC-Pva-102333	Pteropus vampyrus	75.85	0.00e+00	853.00
IUUC-Pgr-103401	Puccinia graminis	32.85	1.00e-80	294.00
IUUC-Ptt-103889	Puccinia triticina	27.30	1.00e-57	217.00
IUUC-Pte-104355	Pyrenophora teres	36.59	2.00e-89	323.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.99	2.00e-89	322.00
IUUC-Rno-105810	Rattus norvegicus	78.65	0.00e+00	899.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.72	5.00e-39	155.00
IUUC-Sha-106770	Sarcophilus harrisii	82.78	2.00e-140	491.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	34.72	2.00e-79	289.00
IUUC-Spo-108276	Schizosaccharomyces pombe	36.67	5.00e-86	311.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	34.68	1.00e-72	267.00
IUUC-Smo-109296	Selaginella moellendorffii	43.94	2.00e-127	449.00
IUUC-Sit-110157	Setaria italica	44.03	2.00e-132	465.00
IUUC-Sly-111105	Solanum lycopersicum	40.94	1.00e-123	436.00
IUUC-Stu-112469	Solanum tuberosum	41.02	9.00e-125	440.00
IUUC-Sar-113083	Sorex araneus	59.11	1.00e-180	625.00
IUUC-Sbi-113813	Sorghum bicolor	44.49	3.00e-130	458.00
IUUC-Sre-115058	Sporisorium reilianum	38.53	3.00e-83	302.00
IUUC-Tgu-116772	Taeniopygia guttata	74.57	0.00e+00	828.00
IUUC-Tru-118686	Takifugu rubripes	69.98	0.00e+00	816.00
IUUC-Tsy-119111	Tarsius syrichta	75.36	2.00e-126	445.00
IUUC-Tni-120231	Tetraodon nigroviridis	63.81	0.00e+00	730.00
IUUC-Tca-121491	Theobroma cacao	40.68	8.00e-118	417.00
IUUC-Tre-122103	Trichoderma reesei	36.89	2.00e-82	300.00
IUUC-Tvi-122672	Trichoderma virens	35.83	6.00e-76	278.00
IUUC-Tae-125316	Triticum aestivum	43.18	3.00e-126	445.00
IUUC-Tur-126487	Triticum urartu	42.20	3.00e-120	425.00
IUUC-Tme-127097	Tuber melanosporum	39.38	1.00e-96	347.00
IUUC-Ttr-128465	Tursiops truncatus	73.77	0.00e+00	832.00
IUUC-Uma-129645	Ustilago maydis	33.89	9.00e-89	320.00
IUUC-Vda-129989	Verticillium dahliae	32.20	7.00e-60	224.00
IUUC-Vpa-130529	Vicugna pacos	74.91	0.00e+00	853.00
IUUC-Vvi-131059	Vitis vinifera	41.06	2.00e-121	429.00
IUUC-Xma-133930	Xiphophorus maculatus	72.42	0.00e+00	825.00
IUUC-Yli-134505	Yarrowia lipolytica	34.48	5.00e-84	304.00
IUUC-Zma-135895	Zea mays	44.10	8.00e-129	453.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence