iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071340

Ensembl Protein ID

ENSONIP00000013700.1

UniProt Accession

I3JXV5; I3JXV5_ORENI

Genbank Protein ID

ENSONIP00000013700

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01072579

Gene Name

si:ch211-37e10.1; LOC100693669

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000010887.1	ENSONIT00000013710.1	ENSONIP00000013700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-27	96.5	91	413

Active Site

Position(s)	Description	Evidence
382	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++ ++v+f++     Ee++d+gG+trefl+ll++++ +    +f+ ++  k+ ++ ++++     ++ ++F ++Gr++++++++g + +
   Q: 91   NSGMMVKFSDdvglaEEAIDTGGPTREFLTLLMEAIRTRR--IFEGKDYAKYLTFHSKAA-----DENEYF-YIGRMIAVSIVHGGPGP 171
           566789999999999********************99988..7*9999999998888877.....456777.89*************** PP
   S: 90   lplsksfyklllgkklsl.edleev.dpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           + ls+ f+  l+gk+ ++   + ++ d+e+ k l eik+   ++++el   +  ++++    ++ ++    g+ + + t e+k++ v +
   Q: 172  CCLSPNFFMYLVGKDKTFeAPIDDIpDEEIKKALLEIKNA--TSLSEL--RVITEKHS----SMLQT---AGCYRFMRTLEDKKKVVAD 249
           **************87775567777255555669999966..344443..33333333....33333...57779************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket..ky....kggytedspaiqwFwevleefsse 259
           ++++ +  + +  +++freG+ ++  l+ l+      ++ ++  e+ ++++ l++    ++     +  +e+ ++i +  + l ++++ 
   Q: 250  YIQWYFIYRNHLSIQSFREGLATLDFLNALEQHPSLFFSFMCYTETRLTADLLENIFhvQFgppgSSRRQEETRVISYWQDYLLSVEER 338
           **************************************************999996644669876444566666665555566777666 PP
   S: 260  e....rkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +      ++L F+Tg  ++P++ +++ ++ lf     ++++r+P +  C+n++k+P   s+e ++e + y i+++ gF+l
   Q: 339  NgslsLEDILMFATGLREIPPAAIQPKPRLLF-----QTTSRFPVADVCANTIKIPVLHSYEDFQEAMDYGIQNSPGFGL 413
           51111567788*********966666553333.....3567*************************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MYFNLLFLLF FDSMYTNIYA PVIIDSSSSD AEGEELQKEN CDEPDGLTAA DVISNLALKI 60
NKTSCSRFNI NRANVWDGAY RGFRRSSYSP NSGMMVKFSD DVGLAEEAID TGGPTREFLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAGAGCCA GAATTACTAT TACATAAAAT GTATTTTAAT CTTCTGTTTT TACTCTTCTT 60
TGACAGTATG TATACCAATA TCTATGCACC TGTCATTATT GACAGCAGTT CTTCAGATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Dre-028039	Danio rerio	40.71	4.00e-83	303.00
IUUC-Gmo-039715	Gadus morhua	37.76	6.00e-77	281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence