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Tag Content
iUUCD ID IUUC-Apl-004145
Ensembl Protein ID ENSAPLP00000004393.1
UniProt Accession U3IAX1; U3IAX1_ANAPL
Genbank Protein ID ENSAPLP00000004393
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID ADON01095148
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAPLG00000004850.1 ENSAPLT00000005009.1 ENSAPLP00000004393.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.90e-91 306.4 181 804
Active Site
Position(s) Description Evidence
190 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
740 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp..........kepkgellkslqklfeelwkskkkavsp 70
    +Gl+NlgNtC++N+v+Q Ls++p lrell+e e+p +p g+l+ +++++++e++++kk++v+p
   Q: 181 KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEakmpdttvkI-------ESPelsmepqlikLDPPGPLTLAMHQFLTEMQETKKGVVTP 262
    5******************************7643333331.......333666666677789999*********************** PP
   S: 71 rellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
    +el+++++k+a +f+gy+qqD+qE+l++lld+++ e + + +++ ++++++ +++++e++kkk ks+i+++F+g+l+s+i
   Q: 263 KELFAQVCKKAIRFKGYQQQDSQELLRYLLDGMRAEEIQrvsvgILKALTDSNKQNEEELKTKIKEYEKKKGMKSFIDRIFGGELTSTI 351
    *********************************987755577764444455555555555666799*********************** PP
   S: 155 kclecdnvssreepfldlslpvpgkeetkke.......................................................... 185
    +c+ec++vs +e+fldlslpvp++++tk++
   Q: 352 MCEECKTVSLVHESFLDLSLPVPDDQKTKNTnernakknkekesegeeedkndgcyikqrdeplgtskhlqkktkklakkqaksqrrlq 440
    **************************99988********************************************************** PP
   S: 186 ......................................................................................... 185
   
   Q: 441 klqgkvlqladicateqskkdaeynqereadinsetpdvkqeeessndckdhclthedlsiegterevqnmlentgkpeqecvekeslm 529
    ***************************************************************************************** PP
   S: 186 ......................................................................................slq 188
    s++
   Q: 530 dlptealdspvklvngldnlslkdeddenedeeglatdfskihlsdnvesdmsilndlqtcevltedpemafctlanredlnpeegSIH 618
    ***************************************************************************************** PP
   S: 189 dcLesftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
    +cL +ft +e+l ++nk+ c+ c+++ a+k++ ++ P++L+lhLkRf ++++ + +k+n++++fp+ +dl+
   Q: 619 HCLYQFTHNEKLSEKNKLLCDVCTQRHCgpknmksekkyvytnAKKQMLISLTPPILTLHLKRF--QQAGFNLRKVNRHIKFPEVIDLA 705
    ************************7777788888888888888*********************..9999******************* PP
   S: 263 pfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevkeeevle 324
    pfct ++++++e k+ Y+L++vv HsG+++sGHY+ay+k kg+W++++D++V++v+ ++vl+
   Q: 706 PFCTVKCKNVAEgstKVLYSLYGVVEHSGTMRSGHYTAYAKMrnmnkhlsdlvlkgqspealetepVKGQWFHISDTHVQAVSLSKVLS 794
    *****99999889999**************************9999999999988888888887777999******************* PP
   S: 325 etgstaYvlfYkr 337
    s+aY+lfY+r
   Q: 795 ---SQAYLLFYER 804
    ...********98 PP
   

Organism Anas platyrhynchos
Functional Description
(View)

Functional Description



     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
FVEPTCRHIR KGLEQGHLKK ALVNVEWHVC QDCKADNKTQ ENSEEETDES PSIWLCLKCG 60
HRGCGRNSPE QHALKHYTTP RSDPHCLVLS LDNWSVWCYI CDNEVPYSTS TRLGQTVEYV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Apl-004145|DUB,USP|Anas platyrhynchos
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTGTAGAAC CTACGTGCAG GCATATTCGT AAAGGACTGG AACAAGGTCA TCTGAAAAAG 60
GCCCTTGTGA ACGTGGAATG GCACGTTTGC CAGGACTGCA AGGCAGACAA TAAGACACAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Apl-004145|DUB,USP|Anas platyrhynchos
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 34.52 5.00e-28 119.00
IUUC-Aml-001931 Ailuropoda melanoleuca 60.49 0.00e+00 893.00
IUUC-Atr-003015 Amborella trichopoda 29.98 2.00e-35 144.00
IUUC-Aca-004314 Anolis carolinensis 61.40 0.00e+00 871.00
IUUC-Ame-011659 Astyanax mexicanus 58.85 6.00e-65 241.00
IUUC-Bta-013362 Bos taurus 61.58 0.00e+00 895.00
IUUC-Bdi-014624 Brachypodium distachyon 29.66 5.00e-30 126.00
IUUC-Bol-015941 Brassica oleracea 30.02 6.00e-34 139.00
IUUC-Bra-016751 Brassica rapa 29.60 3.00e-31 130.00
IUUC-Cja-019177 Callithrix jacchus 63.55 0.00e+00 930.00
IUUC-Cfa-020051 Canis familiaris 60.81 0.00e+00 910.00
IUUC-Cpo-021886 Cavia porcellus 59.20 0.00e+00 896.00
IUUC-Csa-024103 Chlorocebus sabaeus 63.18 0.00e+00 932.00
IUUC-Cho-024315 Choloepus hoffmanni 58.47 2.00e-74 273.00
IUUC-Cin-025775 Ciona intestinalis 49.65 3.00e-39 153.00
IUUC-Csv-026075 Ciona savignyi 49.75 2.00e-54 206.00
IUUC-Dre-028388 Danio rerio 52.97 2.00e-111 396.00
IUUC-Dno-029409 Dasypus novemcinctus 61.89 0.00e+00 932.00
IUUC-Dor-030443 Dipodomys ordii 57.14 1.00e-123 437.00
IUUC-Ete-032807 Echinops telfairi 62.09 9.00e-145 507.00
IUUC-Eca-033479 Equus caballus 62.65 0.00e+00 921.00
IUUC-Eeu-034835 Erinaceus europaeus 55.64 3.00e-100 359.00
IUUC-Fca-036320 Felis catus 61.83 0.00e+00 920.00
IUUC-Fal-037029 Ficedula albicollis 78.26 0.00e+00 1116.00
IUUC-Gmo-039480 Gadus morhua 52.56 4.00e-109 388.00
IUUC-Gga-040527 Gallus gallus 85.08 0.00e+00 1221.00
IUUC-Gac-042343 Gasterosteus aculeatus 52.61 2.00e-111 396.00
IUUC-Gma-043919 Glycine max 29.92 1.00e-36 148.00
IUUC-Ggo-045598 Gorilla gorilla 63.67 0.00e+00 928.00
IUUC-Hsa-046598 Homo sapiens 62.94 0.00e+00 929.00
IUUC-Hvu-047146 Hordeum vulgare 34.54 2.00e-27 117.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 62.14 0.00e+00 926.00
IUUC-Lch-050536 Latimeria chalumnae 50.77 0.00e+00 684.00
IUUC-Lpe-050703 Leersia perrieri 35.05 2.00e-27 118.00
IUUC-Loc-051814 Lepisosteus oculatus 57.99 5.00e-124 438.00
IUUC-Laf-053732 Loxodonta africana 60.97 0.00e+00 901.00
IUUC-Mcc-054661 Macaca mulatta 63.30 0.00e+00 933.00
IUUC-Meu-055967 Macropus eugenii 64.21 1.00e-126 446.00
IUUC-Mtr-057945 Medicago truncatula 31.34 3.00e-34 140.00
IUUC-Mga-059551 Meleagris gallopavo 84.24 0.00e+00 1241.00
IUUC-Mvi-060391 Microbotryum violaceum 32.49 2.00e-19 91.30
IUUC-Mmr-061747 Microcebus murinus 63.02 0.00e+00 921.00
IUUC-Mdo-062220 Monodelphis domestica 61.04 0.00e+00 872.00
IUUC-Mmu-063582 Mus musculus 59.86 0.00e+00 855.00
IUUC-Mac-064941 Musa acuminata 35.40 4.00e-39 155.00
IUUC-Mpu-066339 Mustela putorius furo 60.56 0.00e+00 910.00
IUUC-Mlu-067511 Myotis lucifugus 61.45 0.00e+00 898.00
IUUC-Nfi-068306 Neosartorya fischeri 29.21 2.00e-12 66.60
IUUC-Nle-069252 Nomascus leucogenys 63.91 0.00e+00 931.00
IUUC-Opr-070969 Ochotona princeps 61.00 0.00e+00 879.00
IUUC-Ont-071786 Oreochromis niloticus 52.26 7.00e-113 401.00
IUUC-Ocu-074704 Oryctolagus cuniculus 63.16 0.00e+00 928.00
IUUC-Oba-075094 Oryza barthii 28.79 6.00e-29 122.00
IUUC-Obr-076743 Oryza brachyantha 35.57 2.00e-27 117.00
IUUC-Ogl-077739 Oryza glaberrima 28.79 5.00e-29 122.00
IUUC-Ogu-078851 Oryza glumaepatula 28.79 6.00e-29 122.00
IUUC-Oin-079402 Oryza indica 28.79 6.00e-29 122.00
IUUC-Olo-080431 Oryza longistaminata 28.79 5.00e-29 122.00
IUUC-Ome-081580 Oryza meridionalis 28.48 9.00e-29 122.00
IUUC-Oni-082644 Oryza nivara 28.79 6.00e-29 122.00
IUUC-Opu-083452 Oryza punctata 28.83 9.00e-29 122.00
IUUC-Oru-084546 Oryza rufipogon 28.79 7.00e-29 122.00
IUUC-Osa-085858 Oryza sativa 28.79 6.00e-29 122.00
IUUC-Ola-086795 Oryzias latipes 53.16 1.00e-106 380.00
IUUC-Oga-088713 Otolemur garnettii 61.50 0.00e+00 915.00
IUUC-Oar-089887 Ovis aries 61.82 0.00e+00 894.00
IUUC-Ptr-091670 Pan troglodytes 62.82 0.00e+00 924.00
IUUC-Pan-092293 Papio anubis 63.30 0.00e+00 933.00
IUUC-Psi-093101 Pelodiscus sinensis 65.81 0.00e+00 956.00
IUUC-Ppa-095622 Physcomitrella patens 29.89 1.00e-35 145.00
IUUC-Pfo-097202 Poecilia formosa 52.68 7.00e-115 407.00
IUUC-Pab-098773 Pongo abelii 62.69 0.00e+00 704.00
IUUC-Pop-099136 Populus trichocarpa 30.93 1.00e-39 158.00
IUUC-Pca-101069 Procavia capensis 53.77 2.00e-101 363.00
IUUC-Ppe-101794 Prunus persica 31.76 6.00e-38 152.00
IUUC-Pva-103092 Pteropus vampyrus 54.17 5.00e-105 375.00
IUUC-Rno-105237 Rattus norvegicus 60.05 0.00e+00 860.00
IUUC-Sha-106889 Sarcophilus harrisii 62.00 0.00e+00 875.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.59 1.00e-10 61.20
IUUC-Sit-110283 Setaria italica 31.21 4.00e-31 130.00
IUUC-Sly-111487 Solanum lycopersicum 30.69 2.00e-40 160.00
IUUC-Stu-112820 Solanum tuberosum 30.96 2.00e-43 170.00
IUUC-Sar-113530 Sorex araneus 58.65 0.00e+00 874.00
IUUC-Sbi-113785 Sorghum bicolor 34.84 8.00e-23 102.00
IUUC-Ssc-116091 Sus scrofa 62.32 0.00e+00 906.00
IUUC-Tgu-117478 Taeniopygia guttata 75.62 0.00e+00 1078.00
IUUC-Tru-118640 Takifugu rubripes 53.87 2.00e-115 409.00
IUUC-Tsy-119042 Tarsius syrichta 51.20 2.00e-154 539.00
IUUC-Tni-120015 Tetraodon nigroviridis 53.09 4.00e-109 389.00
IUUC-Tca-121701 Theobroma cacao 30.83 8.00e-41 162.00
IUUC-Tae-125351 Triticum aestivum 33.51 2.00e-25 111.00
IUUC-Tur-126788 Triticum urartu 33.51 1.00e-25 111.00
IUUC-Tbe-127309 Tupaia belangeri 63.61 7.00e-107 381.00
IUUC-Ttr-128271 Tursiops truncatus 61.59 0.00e+00 901.00
IUUC-Vpa-130674 Vicugna pacos 61.29 0.00e+00 822.00
IUUC-Xtr-131869 Xenopus tropicalis 52.94 0.00e+00 770.00
IUUC-Xma-134195 Xiphophorus maculatus 54.07 1.00e-115 410.00
IUUC-Zma-135157 Zea mays 28.53 2.00e-26 114.00
Created Date 25-Jun-2017

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