iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042343

UUCD1 version

UUC-GaA-01246

Ensembl Protein ID

ENSGACP00000015615.1

UniProt Accession

G3PDE1; G3PDE1_GASAC

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

usp16; USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000011804.1	ENSGACT00000015646.1	ENSGACP00000015615.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.90e-82	276.2	217	825

Active Site

Position(s)	Description	Evidence
226	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
765	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................kepkgellkslqklfeelwkskkkavspre 72
           +Gl+NlgNtC++N+v+Q Ls+++ lr+ l++ ++e+++   +                  ++ g+l+ ++ +l++e+++skk++v+pre
   Q: 217  KGLSNLGNTCFFNAVIQNLSQTHILRQTLNKVTEENISLHIKpvsssdllcvqapiltqLGQPGSLTLAMCQLLNEIQQSKKGVVTPRE 305
           5******************************777776665556788888888888888888888************************* PP
   S: 73   llkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqik 155
           l+++++k+a +f+g++qqD+qE+l++lld+++ e +++ ++ ++++ +e+++ ++ +      +e++k+   k++++++F+g+++s+i+
   Q: 306  LFTQVCKKAARFKGFQQQDSQELLRYLLDGMRAEESRRVSSGISDALKESRKGTDGDqlktlvKEYEKNGCPKNFVDQVFGGEMTSTIM 394
           ***********************************9977777777777776666666788889999999999***************** PP
   S: 156  clecdnvssreepfldlslpvpgkeetkke........................................................... 185
           c++c++vs+ +e fldlslpv+++  +kk+                                                           
   Q: 395  CQQCKTVSVVTEMFLDLSLPVSDEAYRKKNlkkavqstsessqdernspaltngndddlsgsgskyqqkkakkqakkqakhqkrqqkie 483
           ************************99988899********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 484  drvtldnlssasqteseqtnaaadakdgenadnatdeeaslsegspaqisaseqdqqnlnpvedkekeedvdsvidcdpsvsnrftvls 572
           ***************************************************************************************** PP
   S: 186  ..................................................................slqdcLesftkeeelegenkyyc 208
                                                                             s+q+cL +ft+ e+l+++n + c
   Q: 573  deqpskdvvsdadkisemdlerdedgtqlesevepleekeytvvsqdpelafctlatrtapekqecSVQSCLFHFTEVETLTQNNSLLC 661
           ***************************************************************************************** PP
   S: 209  ekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkk 277
            +c+k q                  a k++ +++ P+vL+lhLkRf  +++++s  k+n++v+fpl Ldl+pfc+ ++e+ +e   ++ 
   Q: 662  VTCTKVQSnkekvggsgskknvytdALKQMLISSPPPVLTLHLKRF--QQNGYSICKVNRHVSFPLILDLAPFCVVKCENLTEvdsQVL 748
           ****777788888888888888999*********************..88889999********************9999888888*** PP
   S: 278  YeLiavvvHsGslssGHYvayvkn....................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+++v HsG+++sGHY+ayvk                      +g+W++++D++V++v+e++v+    ++aY+lfY+r
   Q: 749  YSLYGIVEHSGTMRSGHYTAYVKArsechkpssngfiaegreapPRGSWFHVSDTSVQPVSESKVQG---CQAYLLFYER 825
           ************************999999999988888777777888*******************...********98 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MVKKKGKDNS SREEDEIDLA GPSCRHIKKG TDQTLLKKLS GNSNWTSCQH CKHEENKENI 60
STPVAQNSEE EQETIPIWMC LKCGHIGCGQ NSTNRHAIKH YETPRSEPHC LVISLDNWSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCTGTCGA GTTTTTTTTT TTGTTGCGAT ATTGTGATTT ACTGGACCCC CTTTCTCTTC 60
TTTCCGGATG AGATAATTAA TCCATTCAAA GTGTTTTTTT AAACTGCAGA CTGTGACAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	32.68	7.00e-24	106.00
IUUC-Aml-001931	Ailuropoda melanoleuca	50.47	1.00e-110	394.00
IUUC-Atr-003015	Amborella trichopoda	29.81	3.00e-35	144.00
IUUC-Apl-004145	Anas platyrhynchos	52.61	3.00e-104	373.00
IUUC-Aca-004314	Anolis carolinensis	44.90	4.00e-175	608.00
IUUC-Ame-011659	Astyanax mexicanus	54.00	4.00e-138	485.00
IUUC-Bta-013362	Bos taurus	48.97	9.00e-107	381.00
IUUC-Bdi-014624	Brachypodium distachyon	34.00	1.00e-23	105.00
IUUC-Cja-019177	Callithrix jacchus	46.92	0.00e+00	635.00
IUUC-Cfa-020051	Canis familiaris	50.47	3.00e-110	392.00
IUUC-Cpo-021886	Cavia porcellus	44.78	3.00e-175	608.00
IUUC-Csa-024103	Chlorocebus sabaeus	46.22	0.00e+00	632.00
IUUC-Cho-024315	Choloepus hoffmanni	45.96	4.00e-50	192.00
IUUC-Cin-025775	Ciona intestinalis	44.52	1.00e-35	141.00
IUUC-Csv-026075	Ciona savignyi	45.50	1.00e-50	194.00
IUUC-Cme-027348	Cyanidioschyzon merolae	36.81	6.00e-17	82.80
IUUC-Dre-028388	Danio rerio	55.12	0.00e+00	800.00
IUUC-Dno-029409	Dasypus novemcinctus	44.99	0.00e+00	633.00
IUUC-Dor-030443	Dipodomys ordii	45.36	3.00e-79	289.00
IUUC-Ete-032807	Echinops telfairi	45.28	3.00e-91	329.00
IUUC-Eca-033479	Equus caballus	49.43	2.00e-111	397.00
IUUC-Eeu-034835	Erinaceus europaeus	58.45	2.00e-71	264.00
IUUC-Fca-036320	Felis catus	46.39	0.00e+00	636.00
IUUC-Fal-037029	Ficedula albicollis	42.29	3.00e-169	588.00
IUUC-Gmo-039480	Gadus morhua	60.09	4.00e-148	518.00
IUUC-Gga-040527	Gallus gallus	51.16	3.00e-103	369.00
IUUC-Gma-043919	Glycine max	28.74	1.00e-33	139.00
IUUC-Ggo-045598	Gorilla gorilla	46.61	0.00e+00	631.00
IUUC-Hsa-046598	Homo sapiens	46.89	0.00e+00	634.00
IUUC-Hvu-047146	Hordeum vulgare	33.50	1.00e-23	105.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	46.57	0.00e+00	630.00
IUUC-Lch-050536	Latimeria chalumnae	48.23	1.00e-100	360.00
IUUC-Lpe-050703	Leersia perrieri	34.98	1.00e-23	105.00
IUUC-Loc-051814	Lepisosteus oculatus	54.85	0.00e+00	780.00
IUUC-Laf-053732	Loxodonta africana	45.74	0.00e+00	629.00
IUUC-Mcc-054661	Macaca mulatta	46.45	0.00e+00	635.00
IUUC-Meu-055967	Macropus eugenii	46.17	8.00e-93	335.00
IUUC-Mtr-057945	Medicago truncatula	32.00	5.00e-34	140.00
IUUC-Mga-059551	Meleagris gallopavo	51.89	2.00e-109	390.00
IUUC-Mmr-061747	Microcebus murinus	47.31	0.00e+00	632.00
IUUC-Mmu-063582	Mus musculus	44.91	4.00e-171	595.00
IUUC-Mac-064941	Musa acuminata	28.64	2.00e-35	144.00
IUUC-Mpu-066339	Mustela putorius furo	49.77	1.00e-109	390.00
IUUC-Mlu-067511	Myotis lucifugus	49.20	2.00e-108	386.00
IUUC-Nle-069252	Nomascus leucogenys	46.68	0.00e+00	637.00
IUUC-Opr-070969	Ochotona princeps	46.89	5.00e-179	621.00
IUUC-Ont-071786	Oreochromis niloticus	71.18	0.00e+00	1065.00
IUUC-Ocu-074704	Oryctolagus cuniculus	46.84	0.00e+00	637.00
IUUC-Oba-075094	Oryza barthii	39.60	1.00e-24	108.00
IUUC-Obr-076743	Oryza brachyantha	38.93	3.00e-24	107.00
IUUC-Ogl-077739	Oryza glaberrima	33.99	2.00e-24	108.00
IUUC-Ogu-078851	Oryza glumaepatula	39.60	1.00e-24	108.00
IUUC-Oin-079402	Oryza indica	39.60	1.00e-24	108.00
IUUC-Olo-080431	Oryza longistaminata	39.38	6.00e-25	109.00
IUUC-Ome-081580	Oryza meridionalis	39.60	1.00e-24	108.00
IUUC-Oni-082644	Oryza nivara	39.60	1.00e-24	108.00
IUUC-Opu-083452	Oryza punctata	34.48	1.00e-24	108.00
IUUC-Oru-084546	Oryza rufipogon	39.60	1.00e-24	108.00
IUUC-Osa-085858	Oryza sativa	39.60	1.00e-24	108.00
IUUC-Ola-086795	Oryzias latipes	62.97	0.00e+00	920.00
IUUC-Oar-089887	Ovis aries	45.41	9.00e-172	597.00
IUUC-Ptr-091670	Pan troglodytes	46.85	0.00e+00	632.00
IUUC-Pan-092293	Papio anubis	46.45	0.00e+00	635.00
IUUC-Psi-093101	Pelodiscus sinensis	48.82	7.00e-107	381.00
IUUC-Ppa-095584	Physcomitrella patens	28.57	5.00e-38	153.00
IUUC-Pfo-097202	Poecilia formosa	65.06	0.00e+00	1050.00
IUUC-Pop-099136	Populus trichocarpa	30.75	4.00e-36	146.00
IUUC-Pca-101069	Procavia capensis	43.16	7.00e-70	258.00
IUUC-Ppe-101794	Prunus persica	31.84	7.00e-34	139.00
IUUC-Pva-103092	Pteropus vampyrus	54.17	3.00e-70	259.00
IUUC-Rno-105237	Rattus norvegicus	48.36	8.00e-103	368.00
IUUC-Sha-106889	Sarcophilus harrisii	49.40	5.00e-105	375.00
IUUC-Spo-108149	Schizosaccharomyces pombe	33.33	9.00e-23	102.00
IUUC-Sit-110283	Setaria italica	38.41	1.00e-25	112.00
IUUC-Sly-111491	Solanum lycopersicum	29.02	1.00e-34	142.00
IUUC-Stu-112820	Solanum tuberosum	28.61	7.00e-38	152.00
IUUC-Sar-113530	Sorex araneus	49.77	2.00e-107	383.00
IUUC-Sbi-113785	Sorghum bicolor	41.10	3.00e-24	107.00
IUUC-Ssc-116091	Sus scrofa	45.69	9.00e-177	613.00
IUUC-Tgu-117478	Taeniopygia guttata	47.48	5.00e-101	362.00
IUUC-Tru-118640	Takifugu rubripes	64.56	0.00e+00	947.00
IUUC-Tsy-119042	Tarsius syrichta	38.35	9.00e-105	374.00
IUUC-Tni-120015	Tetraodon nigroviridis	63.11	0.00e+00	940.00
IUUC-Tca-121701	Theobroma cacao	29.09	2.00e-37	151.00
IUUC-Tae-125785	Triticum aestivum	33.00	7.00e-23	103.00
IUUC-Tur-126788	Triticum urartu	33.00	5.00e-23	103.00
IUUC-Tbe-127309	Tupaia belangeri	44.13	3.00e-66	246.00
IUUC-Ttr-128271	Tursiops truncatus	49.57	4.00e-113	402.00
IUUC-Vpa-130674	Vicugna pacos	51.26	8.00e-112	398.00
IUUC-Xtr-131869	Xenopus tropicalis	46.19	1.00e-106	380.00
IUUC-Xma-134195	Xiphophorus maculatus	66.20	0.00e+00	1038.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence