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Tag Content
UUCD2 ID IUUC-Aml-001432
UUCD1 version UUC-AiM-00610
Ensembl Protein ID ENSAMEP00000011364.1
UniProt Accession G1LWB3; G1LWB3_AILME
Genbank Protein ID ENSAMEP00000011364
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID ACTA01154138
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000010759.1 ENSAMET00000011848.1 ENSAMEP00000011364.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-60 196.4 745 780
UBD/Beta-Prp 6.30e-125 416.4 618 779
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 745  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVKSAN 780
           8***********777****************98765 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ + d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vh++ +h+++v
   Q: 618  HTDAVYHACFSEDGQRIASCGVDKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHIYDEHSEQV 706
           44555556667777777777777777777777777777777777777777777776677777777777777777777777777777777 PP
   S: 98   lslsfspsgdk..lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
            +++f  ++++  l+++s+d  +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd+k++
   Q: 707  NCCHFTNNSHYllLATASSDCFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDVKSA 779
           77777665543113566667777777777777776.67777777777777777777777777777777776554 PP
   
Organism Ailuropoda melanoleuca
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
GRMDAKARNC LLQHREALER DIKTSYIMDR MINDGVLTVS EEEKVKNEPT QQQRAALLIK 60
MILKKDNYSY ISFYNALIHE GYKDLAALLH SGIPVISSSN GGKDSVGGIT SYVKTVLCEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-001432|E3,WD_repeat;UBD,Beta-Prp|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGGATGG ACGCAAAAGC TCGAAACTGT TTGCTTCAAC ATAGAGAAGC CCTGGAAAGA 60
GACATCAAAA CGTCCTACAT CATGGATCGT ATGATTAATG ATGGAGTTTT AACAGTGTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-001432|E3,WD_repeat;UBD,Beta-Prp|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004201 Anas platyrhynchos 71.21 0.00e+00 1826.00
IUUC-Aca-004638 Anolis carolinensis 69.51 0.00e+00 1808.00
IUUC-Ani-009285 Aspergillus nidulans 25.65 9.00e-67 249.00
IUUC-Ame-011062 Astyanax mexicanus 54.07 0.00e+00 1349.00
IUUC-Bta-012865 Bos taurus 91.31 0.00e+00 2365.00
IUUC-Cja-018815 Callithrix jacchus 80.97 0.00e+00 2031.00
IUUC-Cfa-020222 Canis familiaris 92.79 0.00e+00 2347.00
IUUC-Cpo-021524 Cavia porcellus 88.18 0.00e+00 2252.00
IUUC-Csa-023861 Chlorocebus sabaeus 91.29 0.00e+00 2313.00
IUUC-Cho-024484 Choloepus hoffmanni 81.19 0.00e+00 1210.00
IUUC-Dre-028006 Danio rerio 52.84 0.00e+00 1242.00
IUUC-Dno-029591 Dasypus novemcinctus 91.93 0.00e+00 2381.00
IUUC-Dor-030237 Dipodomys ordii 76.41 0.00e+00 1071.00
IUUC-Ete-032620 Echinops telfairi 85.00 0.00e+00 1092.00
IUUC-Eca-033569 Equus caballus 92.02 0.00e+00 2359.00
IUUC-Eeu-035354 Erinaceus europaeus 67.01 1.00e-177 617.00
IUUC-Fca-036337 Felis catus 95.85 0.00e+00 2474.00
IUUC-Fal-037077 Ficedula albicollis 70.69 0.00e+00 1817.00
IUUC-Gmo-039687 Gadus morhua 51.12 0.00e+00 926.00
IUUC-Gga-040299 Gallus gallus 69.46 0.00e+00 1825.00
IUUC-Gac-041762 Gasterosteus aculeatus 52.12 0.00e+00 1276.00
IUUC-Ggo-045563 Gorilla gorilla 91.47 0.00e+00 2330.00
IUUC-Hsa-046771 Homo sapiens 91.13 0.00e+00 2318.00
IUUC-Lch-050200 Latimeria chalumnae 65.73 0.00e+00 1639.00
IUUC-Loc-052090 Lepisosteus oculatus 59.34 0.00e+00 1506.00
IUUC-Laf-053861 Loxodonta africana 90.26 0.00e+00 2314.00
IUUC-Mcc-055543 Macaca mulatta 91.85 0.00e+00 2329.00
IUUC-Meu-056688 Macropus eugenii 80.64 0.00e+00 2049.00
IUUC-Mga-059243 Meleagris gallopavo 70.06 0.00e+00 1843.00
IUUC-Mmr-061134 Microcebus murinus 85.79 0.00e+00 1982.00
IUUC-Mdo-062913 Monodelphis domestica 79.12 0.00e+00 2045.00
IUUC-Mmu-063811 Mus musculus 87.14 0.00e+00 2270.00
IUUC-Mpu-066780 Mustela putorius furo 97.68 0.00e+00 2442.00
IUUC-Mlu-067276 Myotis lucifugus 91.08 0.00e+00 2354.00
IUUC-Nle-069129 Nomascus leucogenys 91.05 0.00e+00 2316.00
IUUC-Opr-071007 Ochotona princeps 67.37 0.00e+00 1111.00
IUUC-Ont-071348 Oreochromis niloticus 55.19 0.00e+00 1390.00
IUUC-Oan-072717 Ornithorhynchus anatinus 81.04 0.00e+00 2107.00
IUUC-Ocu-074286 Oryctolagus cuniculus 91.27 0.00e+00 1981.00
IUUC-Ola-086895 Oryzias latipes 49.96 0.00e+00 1170.00
IUUC-Oga-088678 Otolemur garnettii 90.34 0.00e+00 2310.00
IUUC-Oar-089359 Ovis aries 90.59 0.00e+00 2331.00
IUUC-Ptr-091062 Pan troglodytes 91.13 0.00e+00 2320.00
IUUC-Pan-092528 Papio anubis 91.91 0.00e+00 1363.00
IUUC-Psi-093430 Pelodiscus sinensis 74.56 0.00e+00 1930.00
IUUC-Pma-094690 Petromyzon marinus 38.38 9.00e-147 514.00
IUUC-Pfo-097204 Poecilia formosa 54.75 0.00e+00 1364.00
IUUC-Pab-097690 Pongo abelii 91.61 0.00e+00 2326.00
IUUC-Pca-100778 Procavia capensis 70.99 0.00e+00 1164.00
IUUC-Pva-102870 Pteropus vampyrus 89.75 0.00e+00 2121.00
IUUC-Rno-104889 Rattus norvegicus 86.90 0.00e+00 2236.00
IUUC-Sha-107465 Sarcophilus harrisii 79.35 0.00e+00 2086.00
IUUC-Sar-113268 Sorex araneus 90.03 0.00e+00 664.00
IUUC-Ssc-115654 Sus scrofa 91.13 0.00e+00 2352.00
IUUC-Tgu-117302 Taeniopygia guttata 70.93 0.00e+00 1832.00
IUUC-Tru-118363 Takifugu rubripes 54.00 0.00e+00 1360.00
IUUC-Tsy-119007 Tarsius syrichta 86.74 0.00e+00 2209.00
IUUC-Tni-120910 Tetraodon nigroviridis 52.71 0.00e+00 1312.00
IUUC-Tbe-127413 Tupaia belangeri 78.02 0.00e+00 1401.00
IUUC-Ttr-129213 Tursiops truncatus 85.22 0.00e+00 2149.00
IUUC-Vpa-130146 Vicugna pacos 87.22 0.00e+00 1647.00
IUUC-Xtr-132559 Xenopus tropicalis 61.31 0.00e+00 1553.00
Created Date 25-Jun-2017

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