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Tag Content
UUCD2 ID IUUC-Cja-018815
UUCD1 version UUC-CaJ-00195
Ensembl Protein ID ENSCJAP00000004288.2
UniProt Accession F6WU20; F6WU20_CALJA
Genbank Protein ID ENSCJAP00000004288
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID ACFV01061087
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000002341.2 ENSCJAT00000004521.2 ENSCJAP00000004288.2
ENSCJAG00000002341.2 ENSCJAT00000004542.2 ENSCJAP00000004308.2
ENSCJAG00000002341.2 ENSCJAT00000004467.1 ENSCJAP00000004237.1
ENSCJAG00000002341.2 ENSCJAT00000004526.2 ENSCJAP00000004293.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.40e-47 157.7 741 776
UBD/Beta-Prp 3.30e-69 234.3 614 868
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH +sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 741  GHINSVSHCRFsPDdKLLASCSADGTLKLWDVTSAN 776
           8999********777*****************9876 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vh + +h+++v
   Q: 614  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHNYDEHSEQV 702
           6777888********************************************************************************** PP
   S: 98   lslsfspsg..dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...........ktgkllr 173
            +++f  s+    l++Gs+d ++++wdl+++qc + tl gh  +v++ +++pd++ll+s+s+D+t++lWd+           k      
   Q: 703  NCCHFTNSShhFLLATGSSDCVLKLWDLNQKQCRN-TLFGHINSVSHCRFSPDDKLLASCSADGTLKLWDVtsanerksinvK------ 784
           *******553345789*******************.***********************************888875444331...... PP
   S: 174  tl.......tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv.rtlnghtdnvksvrfspnderlvsgssDgsiri.W 249
           ++       +++ +  v++ s++ +g +++ +++ +++ l+d+ t++ + ++l gh ++++  +fsp++++ v++ s   + + W
   Q: 785  QFflnsedlQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIYTSDLLgEILMGHHSTIQYCDFSPQNHLAVVALSQYCVEVlW 868
           335666555776777889999*****99887665.579******8877626799************9999998877776666666 PP
   
Organism Callithrix jacchus
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTILEE EKVRNEPTQQ QRAAMLIKMI 60
LKKDNGSYIS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVTGITSYV RTVLCEGGVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cja-018815|E3,WD_repeat;UBD,Beta-Prp|Callithrix jacchus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCTGTTCTA TCCCTGGGCA AAAGGGATAG AACCGGAGGT GTGGAGTCTG GGCAGTCGGC 60
GACCCGCGAA GACTTGAGGT GCCGCGGCGG CGTCCGGAGT AGCGCCGGGC TCCCTCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cja-018815|E3,WD_repeat;UBD,Beta-Prp|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat
Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 80.97 0.00e+00 2012.00
IUUC-Apl-004201 Anas platyrhynchos 65.79 0.00e+00 1655.00
IUUC-Aca-004638 Anolis carolinensis 63.97 0.00e+00 1627.00
IUUC-Ame-011062 Astyanax mexicanus 51.22 0.00e+00 1220.00
IUUC-Bta-012865 Bos taurus 80.61 0.00e+00 2060.00
IUUC-Cfa-020222 Canis familiaris 76.54 0.00e+00 1875.00
IUUC-Cpo-021524 Cavia porcellus 79.01 0.00e+00 1982.00
IUUC-Csa-023861 Chlorocebus sabaeus 84.35 0.00e+00 2119.00
IUUC-Cho-024484 Choloepus hoffmanni 67.50 0.00e+00 997.00
IUUC-Dre-028006 Danio rerio 56.17 0.00e+00 939.00
IUUC-Dno-029591 Dasypus novemcinctus 81.01 0.00e+00 2049.00
IUUC-Dor-030237 Dipodomys ordii 61.13 0.00e+00 832.00
IUUC-Ete-032620 Echinops telfairi 83.57 0.00e+00 1063.00
IUUC-Eca-033569 Equus caballus 80.93 0.00e+00 2035.00
IUUC-Eeu-035354 Erinaceus europaeus 76.42 1.00e-143 504.00
IUUC-Fca-036337 Felis catus 80.94 0.00e+00 2047.00
IUUC-Fal-037077 Ficedula albicollis 65.28 0.00e+00 1646.00
IUUC-Gmo-039687 Gadus morhua 51.55 0.00e+00 796.00
IUUC-Gga-040299 Gallus gallus 64.36 0.00e+00 1664.00
IUUC-Gac-041762 Gasterosteus aculeatus 55.73 0.00e+00 983.00
IUUC-Ggo-045563 Gorilla gorilla 84.90 0.00e+00 2137.00
IUUC-Hsa-046771 Homo sapiens 84.74 0.00e+00 2133.00
IUUC-Lch-050200 Latimeria chalumnae 60.93 0.00e+00 1471.00
IUUC-Loc-052090 Lepisosteus oculatus 59.57 0.00e+00 1100.00
IUUC-Laf-053861 Loxodonta africana 80.69 0.00e+00 2035.00
IUUC-Mcc-055543 Macaca mulatta 84.82 0.00e+00 2129.00
IUUC-Meu-056688 Macropus eugenii 72.89 0.00e+00 1827.00
IUUC-Mga-059243 Meleagris gallopavo 65.05 0.00e+00 1679.00
IUUC-Mmr-061134 Microcebus murinus 80.58 0.00e+00 1837.00
IUUC-Mdo-062913 Monodelphis domestica 71.70 0.00e+00 1812.00
IUUC-Mmu-063811 Mus musculus 77.41 0.00e+00 1985.00
IUUC-Mpu-066780 Mustela putorius furo 80.78 0.00e+00 1993.00
IUUC-Mlu-067276 Myotis lucifugus 80.29 0.00e+00 2046.00
IUUC-Nle-069129 Nomascus leucogenys 84.35 0.00e+00 2112.00
IUUC-Opr-071007 Ochotona princeps 58.39 0.00e+00 926.00
IUUC-Ont-071348 Oreochromis niloticus 50.79 0.00e+00 1239.00
IUUC-Oan-072717 Ornithorhynchus anatinus 73.47 0.00e+00 1867.00
IUUC-Ocu-074286 Oryctolagus cuniculus 79.38 0.00e+00 1701.00
IUUC-Ola-086895 Oryzias latipes 45.45 0.00e+00 1021.00
IUUC-Oga-088678 Otolemur garnettii 80.67 0.00e+00 2028.00
IUUC-Oar-089359 Ovis aries 80.53 0.00e+00 2033.00
IUUC-Ptr-091062 Pan troglodytes 84.66 0.00e+00 2132.00
IUUC-Pan-092528 Papio anubis 94.23 0.00e+00 1382.00
IUUC-Psi-093430 Pelodiscus sinensis 67.57 0.00e+00 1708.00
IUUC-Pma-094690 Petromyzon marinus 35.85 4.00e-119 422.00
IUUC-Pfo-097204 Poecilia formosa 50.59 0.00e+00 1216.00
IUUC-Pab-097690 Pongo abelii 84.90 0.00e+00 2134.00
IUUC-Pca-100778 Procavia capensis 61.96 0.00e+00 980.00
IUUC-Pva-102870 Pteropus vampyrus 77.69 0.00e+00 1800.00
IUUC-Rno-104889 Rattus norvegicus 77.69 0.00e+00 1951.00
IUUC-Sha-107465 Sarcophilus harrisii 71.85 0.00e+00 1847.00
IUUC-Sar-113268 Sorex araneus 90.03 0.00e+00 663.00
IUUC-Ssc-115654 Sus scrofa 81.01 0.00e+00 2057.00
IUUC-Tgu-117302 Taeniopygia guttata 65.20 0.00e+00 1650.00
IUUC-Tru-118363 Takifugu rubripes 50.47 0.00e+00 1214.00
IUUC-Tsy-119007 Tarsius syrichta 78.04 0.00e+00 1956.00
IUUC-Tni-120910 Tetraodon nigroviridis 48.83 0.00e+00 1163.00
IUUC-Tbe-127413 Tupaia belangeri 64.26 0.00e+00 1119.00
IUUC-Ttr-129213 Tursiops truncatus 76.00 0.00e+00 1898.00
IUUC-Vpa-130146 Vicugna pacos 72.27 0.00e+00 1332.00
IUUC-Xtr-132559 Xenopus tropicalis 56.01 0.00e+00 1401.00
Created Date 25-Jun-2017

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